Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment
The aim of this study was to develop eye-drops with cefuroxime (CEF) sodium or vancomycin (VAN) hydrochloride, antibiotics that are instable in water. Anhydrous self-emulsifying oils (SEO) are proposed as a carrier and antibiotics are suspended. In the contact with tear fluid, the formulation should transform into emulsion, with fast dissolution of…
CEOLUS – High compactible Microcrystalline Cellulose
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CEOLUS™KG – High compactible Microcrystalline Cellulose
Benefits
Faciliate high dosage…
Lipid technology for delivery of gene-editing therapies
Gene-editing technology is moving from the research lab to the clinic — one of the most eagerly anticipated biopharma developments in recent history. One of the biggest hurdles to the development of successful gene-editing therapeutics is…
Fabrication of Sustained Release Curcumin-Loaded Solid Lipid Nanoparticles (Cur-SLNs) as a Potential…
The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the…
Machine learning using multi-modal data predicts the production of selective laser sintered 3D…
Three-dimensional (3D) printing is drastically redefining medicine production, offering digital precision and personalized design opportunities. One emerging 3D printing technology is selective laser sintering (SLS), which is garnering…
Influence of PLGA End Groups on the Release Profile of Dexamethasone from Ocular Implants
The present study deals with the development of dexamethasone (DM)-loaded implants using ester end-capped Resomer RG 502 poly(lactic acid-co-glycolic acid) (PLGA) (502), acid end-capped Resomer RG 502H PLGA (502H), and a 502H:502 mixture…
Modelling the Evolution of Pore Structure during the Disintegration of Pharmaceutical Tablets
Pharmaceutical tablet disintegration is a critical process for dissolving and enabling the absorption of the drug substance into the blood stream. The tablet disintegration process consists of multiple connected and interdependent…
Study of the dextrose equivalent of maltodextrins in electrospinning using an ethanol/water mixture…
Maltodextrin (MD) is a natural polymer ideal for electrospinning due to its non-toxicity, water solubility, and low viscosity. In this investigation, MD solutions, each containing a different dextrose equivalent (DE) value of 18, 10, and 4,…
Webinar – Assessing temperature influence on tablet quality attributes
MEDELPHARM is organising a new webinar on Tuesday February 28th, 2022 - 3:00pm CET.
See the webinar topic and what you can learn in the webinar.
The webinar on "Assessing temperature influence on tablet quality attributes" will…
Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the…
Delivery to the brain is a challenging task due to its protection by the blood-brain barrier (BBB). Lipids and fatty acids are reported to affect the permeability of the BBB, although this has not been reported following oral…
Preparation of Free-Flowing Spray-Dried Amorphous Composites Using Neusilin®
A highly porous additive, Neusilin®, with high adsorption capability is investigated to improve bulk properties, hence processability of spray-dried amorphous solid dispersions (ASDs). Griseofulvin (GF) is applied as a model BCS class 2…
Composition-Property Relationships of pH-Responsive Poly[(2-vinylpyridine)-co-(butyl methacrylate)]…
The taste-masking of bitter-tasting active pharmaceutical ingredients is key to ensuring patient compliance when producing oral pharmaceutical formulations. This is generally achieved via the incorporation of pH-responsive, reverse enteric…
A Guide to In Silico Drug Design
The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially available product, often due to factors, such as poor binding affinity, off-target…
Development of an Oral Liquid Formulation of Nicardipine Hydrochloride Compounded with Simple…
Nicardipine hydrochloride is an anti-hypertensive drug that is used off-label to treat hypertension in children. A previous oral formulation of nicardipine hydrochloride was developed using a commercial vehicle as an excipient. However,…
Design and Development of Fluconazole-Loaded Nanocellulose-Eudragit Vaginal Drug Delivery System
Purpose
The purpose of this research work was to evaluate the scaffolds of rice and wheat nanocellulose with Eudragit E100 for vaginal delivery of fluconazole.
Method
The nanocellulose-based scaffolds were fabricated by the…
Prandial state and biological sex modulate clinically relevant efflux transporters to different…
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 (MRP2) are clinically relevant efflux transporters implicated in the oral absorption of many food and drug substrates. Here, we…
Twin Screw Melt Granulation: Alternative Approach for Improving Solubility and Permeability of a…
The current research is focused on investigating the suitability of the twin screw melt granulation (TSMG) approach for improving the solubility of a non-steroidal anti-inflammatory (NSAIDs) drug (ibuprofen), by developing granules using…
Needles to Spheres: Evaluation of inkjet printing as a particle shape enhancement tool
Active pharmaceutical ingredients (APIs) often reveal shapes challenging to process, e.g. acicular structures, and exhibit reduced bioavailability induced by slow dissolution rate. Leveraging the API particles’ surface and bulk properties…
Introducing the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of…
See the fifth issue of Fuji Chemical Industries Technical Newsletter. It presents the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of Simvastatin.
ORAL DISINTEGRATING TABLETS OF SIMVASTATIN WITH F-MELT®…
Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone…
Abstract
Objectives
This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel,…
Advancing oral delivery of biologics: Machine learning predicts peptide stability in the…
The oral delivery of peptide therapeutics could facilitate precision treatment of numerous gastrointestinal (GI) and systemic diseases with simple administration for patients. However, the vast majority of licensed peptide drugs are…
Application of NMP and Neusilin US2-integrated liquisolid technique in mini-tablets for improving…
Frankincense and myrrh are widely used Chinese medicines, showing clinically relevant synergistic therapeutic effects in the treatment of inflammation and cancer. We investigated the applicability of a liquisolid (LS) technique to the…
3D printed multi-drug-loaded suppositories for acute severe ulcerative colitis
Acute severe ulcerative colitis (ASUC) is a growing health burden that often requires treatment with multiple therapeutic agents. As inflammation is localised in the rectum and colon, local drug delivery using suppositories could improve…
FDA Concludes that Existing Regulatory Frameworks for Foods and Supplements are Not Appropriate for…
Given the growing cannabidiol (CBD) products market, the U.S. Food and Drug Administration convened a high-level internal working group to explore potential regulatory pathways for CBD products. Today we are announcing that after careful…
Use of polyvinyl alcohol (PVA) to overcome challenges in ophthalmic formulations
Successful ophthalmic drug formulations rely on the selection of the correct polymer to ensure the desired characteristics such as retention in the eye cavity and solubility. One example of such an excipient is polyvinyl alcohol (PVA) which…
Drug delivery as a sustainable avenue to future therapies
Climate change and the need for sustainable, technological developments are the greatest challenges facing humanity in the coming decades. To address these issues, in 2015 the United Nations have established 17 Sustainable Development…
Stability of APIs in Super Refined PEG – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Polyethylene glycols (PEGs) are excipients that are widely used in oral, parenteral and topical delivery dosage forms. Low molecular weight PEGs, such as PEG 300 and PEG 400 in…
Unveiling the dielectric properties of self-nanoemulsifying drug delivery systems (SNEDDS)
Self-nanoemulsifying Drug Delivery System (SNEDDS) improves the bioavailability of bioactive compounds that exhibit low water solubility. In this regard, our study aims to assess the formulation of SNEDDS in a wide range of oil…
The applications of machine learning to predict the forming of chemically stable amorphous solid…
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various…
Nanosized Drug Delivery Systems to Fight Tuberculosis
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing antitubercular therapies are long, complex, and have severe side effects that result in low patient compliance. In this context, nanosized drug delivery…
Paediatric Solid Oral Dosage Forms for Combination Products: Improving In Vitro Swallowability of…
There is a growing interest in determining and improving the acceptability of solid oral dosage forms (SODF) in paediatric populations. Combination products can be an interesting solution to combine two active pharmaceutical ingredients.…
CELPHERE – Microcrystalline Cellulose seed core
Are you developing MUPS? Difficulties with crushing pellets? Pellet aggregation?
Asahi Kasei is the leading manufacturer and supplier of functional excipients such as microcrystalline cellulose (MCC) in Japan. Read more about the…
Advanced image analytics to study powder mixing in a novel laboratory scale agitated filter dryer
Powder mixing unit operations are essential to the manufacturing of pharmaceutical drug substance and drug products. To model powder mixing, computational approaches have been used to evaluate mixing indices for different types of mixers,…
Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability:…
Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited…
Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug…
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and…