Kolliphor® CS 12 and Kolliphor® CS 20 – emulsifiers by BASF
The science behind emulsifier functionality
Emulsifiers are surface-active substances that reduce the interfacial tension between the oil and water phase of an emulsion. Emulsifiers are adsorbed at the interface, creating a film between the immiscible phases, thus preventing the coalescence of droplets. Due to the amphiphilic structure of an…
Optimized L-SNEDDS and Spray-Dried S-SNEDDS Using a Linked QbD-DM3 Rational Design for Model…
A QbD-DM3 strategy was used to design ketoprofen (KTF) optimized liquid (L-SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS). Principal component analysis was used to identify the optimized L-SNEDDS containing Capmul®…
Comparative study on the topical and transdermal delivery of diclofenac incorporated in…
Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The lack thereof would…
Improving aqueous solubility of paclitaxel with polysarcosine-b-poly(γ-benzyl glutamate)…
New stealth amphiphilic copolymers based on polysarcosine (PSar) rather than poly(ethylene glycol) (PEG) have gained more attention for their use as excipients in nanomedicine. In this study, several polysarcosine-b-poly(γ-benzyl glutamate)…
Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide
The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less…
New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid…
Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs are based on an amorphous API dispersed in a polymer, and their stability…
Improving in vivo oral bioavailability of a poorly soluble drug: a case study on polymeric versus…
Poorly soluble drugs must be appropriately formulated for clinical use to increase the solubility, dissolution rate, and permeation across the intestinal epithelium. Polymeric and lipid nanocarriers have been successfully investigated for…
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics
Abstract
Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation…
Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles…
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately,…
Compatibility Study between Fenbendazole and Polymeric Excipients Used in Pharmaceutical Dosage…
The body of work described in this research paper evaluates the compatibility between Fenbendazole (Fen), which is a broad-spectrum anthelmintic with promising antitumor activity, and three polymeric excipients commonly applied in…
Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease
Abstract
Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the…
Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed…
During drug product development, stability studies are used to ensure that the safety and efficacy of a product are not affected during storage. Any change in the dissolution performance of a product must be investigated, as this may…
World Cancer Day 2024
Create a future without cancer. The time to act is now.
World Cancer Day takes place every year on 4 February and will be held for the 24rd time in 2024 under the theme "Close the Care Gap". The day was initiated as a global…
Design Development and Evaluation of Nanostructured Lipid Carrier Loaded Emulgel of Voriconazole
Voriconazole is a second generation triazole derived from fluconazole. Voriconazole is used for the treatment of various fungal infections. Though it has excellent antifungal activity, there are several side effects associated with it. In…
Liposome-based diagnostic and therapeutic applications for pancreatic cancer
Pancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled as incurable. Chemotherapy continues to be the most popular treatment yet yields a very poor prognosis. The main barriers such as inefficient drug…
Impact of drug loading on release from levonorgestrel intrauterine systems
Levonorgestrel intrauterine systems (LNG-IUSs) are polydimethylsiloxane (PDMS) based non-biodegradable complex drug-device combination products providing efficacy for up to several years based on the strength. A large amount of LNG (e.g., …
Time-Based Formulation Strategies for Colon Drug Delivery
Despite poor absorption properties, delivery to the colon of bioactive compounds administered by the oral route has become a focus of pharmaceutical research over the last few decades. In particular, the high prevalence of Inflammatory…
Relative Humidity Cycling: Implications on the Stability of Moisture-Sensitive Drugs in Solid…
The stability of a moisture-sensitive drug in tablet formulations depends particularly on the environment’s relative humidity (RH) and the products’ prior exposure to moisture. This study was designed to understand drug stability in…
Development of a Near-Infrared Spectroscopy (NIRS)–Based Characterization Approach for Inherent…
With the advent of continuous direct compression (CDC) process, it becomes increasingly desirable to characterize inherent powder blend heterogeneity at a small batch scale for a robust and CDC-amenable formulation. To accomplish this goal,…
Thermoresponsive in-situ gel containing hyaluronic acid and indomethacin for the treatment of…
Ocular chemical burns are prevalent injuries that must have immediate and effective treatment to avoid complications. Aiming to improve bioavailability and efficacy, a poloxamer-based thermoresponsive in-situ gelling system containing…
3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength…
It is still a major challenge to remove tumor cells and fill bone defects after tumor resection. Combined with the 3D printing technology, the composite bioceramics scaffolds were fabricated with interconnected porous magnesium-doped…
A Phase IV, Multicenter, Open-Label, Safety, and Efficacy Study of High-Dose, Propylene Glycol-Free…
Introduction:
ASCT is a standard of care in transplant-eligible MM patients which has been demonstrated with a better complete remission rate (CR) and with longer survival. High-dose melphalan (200 mg/m2) has been the most commonly…
Preparation of nanodelivery systems for oral administration of low molecular weight heparin
Low molecular weight heparins (LMWHs) are only used parenterally. They have low oral absorption and bioavailability due to their high anionic charge density, exposure to enzymatic degradation and first pass effect. The aim of this study was…
A new perspective for psoriasis: Dithranol nanosponge loaded hydrogels
We developed dithranol nanosponge integrated Carbopol hydrogel (DTHNS-HG) as a novel perspective for psoriasis management. Dithranol was chosen as antipsoriatic moiety for this system. In this study, our objective was to fabricate and…
Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis:…
Background: This study was designed considering the challenges of leishmaniasis treatment and the benefits of carriers of drug delivery systems to review plant bioactive ingredients in delivery systems and nanocarriers for the treatment of…
Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed…
Selective laser sintering (SLS) 3D printing is a revolutionary 3D printing technology that has been found capable of creating drug products with varied release profiles by changing the laser scanning speed. Here, SLS 3D printed formulations…
The Match Between Adhesive Mixture Formulation And Device
The LUND University Sweden, Emmercon and the Swedish Foundation for Strategic Research proudly present the following study:
The Match Between Adhesive Mixture Formulation And Device
INTRODUCTION
This study investigates whether it is…
Loading of alpha-tocopherol in a nonionic microemulsion: phase behaviour and structural…
In this research, we present a systematic analysis of events inside single phase region of a nonionic microemulsion (ME) during incorporation of water and α-tocopherol (AT, a hydrophobic payload). The formulation was developed using…
Tablet formulation with dual control concept for efficient colonic drug delivery
Aim of this study was to develop a tablet formulation for targeted colonic drug release by implementing two control mechanisms: A pH-sensitive coating layer based on Eudragit® FS 30 D to prevent drug release in the upper gastrointestinal…
Solid Lipid Microparticles by Spray Congealing of Water/Oil Emulsion: An Effective/Versatile Loading…
Spray congealing technique was exploited to produce solid lipid microparticles (SLMp) loaded with a highly water-soluble drug (metoclopramide hydrochloride) dissolved in the aqueous phase of a water in oil (W/O) emulsion. The use of an…
Challenges and Strategies for Solubility Measurements and Dissolution Method Development for…
This manuscript represents the view of the Dissolution Working Group of the IQ Consortium on the challenges of and recommendations on solubility measurements and development of dissolution methods for immediate release (IR) solid oral…
3D printing: Innovative solutions for patients and pharmaceutical industry
Three-dimensional (3D) printing is an emerging technology with great potential in pharmaceutical applications, providing innovative solutions for both patients and pharmaceutical industry. This technology offers precise construction of the…
Investigation of hot melt extrusion process parameters on solubility and tabletability of…
Reports in the literature indicate that hot-melt extrusion (HME) processing techniques could alter the mechanical properties of the pharmaceutical physical blend, which may alter successful processing during tableting. The aim of this study…
A functional study of tubing material for the spray drying of mRNA-lipoplexes
Kiel University, Germany, and Meggle GmbH & Co. KG present "A functional study of tubing material for the spray drying of mRNA-lipoplexes":
INTRODUCTION
The overall aim of this project is the development of an inhalable dry…
Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and…
Targeted drug and gene delivery using ultrasound and microbubbles (USMB) has the potential to treat several diseases. In vitro investigation of USMB-mediated delivery is of prime importance prior to in vivo studies because it is…