Kolliphor® CS 12 and Kolliphor® CS 20 – emulsifiers by BASF
The science behind emulsifier functionality
Emulsifiers are surface-active substances that reduce the interfacial tension between the oil and water phase of an emulsion. Emulsifiers are adsorbed at the interface, creating a film between the immiscible phases, thus preventing the coalescence of droplets. Due to the amphiphilic structure of an…
Effect of Combination of Carbopol-940 Base and HPMC Gel Extract of Aloe Vera Flesh on Physical…
Aloe vera (Aloe chinensis Barker.) has been shown to be efficacious as an antibacterial which has the potential to treat acne caused by the bacteria Propionibacterium acnes. The use of this combination can increase the viscosity,…
Water as Green Solvent: Methods of Solubilisation and Extraction of Natural Products – Past,…
Water is considered the greenest solvent. Nonetheless, the water solubility of natural products is still an incredibly challenging issue. Indeed, it is nearly impossible to solubilize or to extract many natural products properly using…
Phospholipids in Pharmaceutical Form Line Extensions
The pharmaceutical industry has two main ways to generate new products. The first option is to look for new drug substances. A second option is to employ better formulations of an existing drug product. Such reformulated products are called…
Pharmaceutical oils for Cannabinoid drug products – White Paper
Medicinal Cannabinoids
There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy…
Evonik launches plant-based squalene to boost vaccine efficacy – Press Release
PRESS RELEASE
Essen, Germany, December 6, 2022
Evonik has launched a non-animal-derived squalene suitable for vaccines and other pharmaceutical applications. PhytoSquene® is the first known amaranth oil-derived squalene on the market…
5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid…
5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer (CRC) owing to its potent anticancer effects. However, severe systemic side effects and poor drug accumulation in the CRC tissues limit its efficacy. This…
Reduction of submicron particle agglomeration via melt foaming in solid crystalline suspension
Particle size reduction of poorly water-soluble drug crystals down to the submicron region (0.1–1 µm) is a focus strategy to increase bioavailability. In this context, solid crystalline suspensions (SCS) manufactured in an adapted wet…
Fabrication of Sustained-Release Dosages Using Powder-Based Three-Dimensional (3D) Printing…
Three-dimensional (3D)-printed tablets prepared using powder-based printing techniques like selective laser sintering (SLS) typically disintegrate/dissolve and release the drug within a few minutes because of their inherent porous nature…
BASF Pharma Solutions excipient accepted into FDA Pilot Program for novel excipients – Press…
Florham Park, New Jersey, December 5, 2022 –
BASF Pharma Solutions, a global business unit of BASF, announces today that the U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER), Office of New Drugs, has…
SEDEX—Self-Emulsifying Delivery Via Hot Melt Extrusion: A Continuous Pilot-Scale Feasibility Study
The aim of this study was to develop a continuous pilot-scale solidification and characterization of self-emulsifying drug delivery systems (SEDDSs) via hot melt extrusion (HME) using Soluplus® and Kollidon® VA-64. First, an oil-binding…
α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa
This work aimed to evaluate poly(pseudo)rotaxanes (PPRs) potential for vaginal antifungal delivery. For this, PPRs containing terbinafine (TB) 2 % were obtained using two small surfactants, Kolliphor® RH40 and Gelucire® 48/16, and different…
Trehalose SG – For Exosome Production and Storage brochure
Mesenchymal Stem Cell (MSC)-derived Exosomes
Trehalose SG MSC-derived exosomes are attracting attention for their application in regenerative medicine, drug delivery, diagnostics and cosmetics, and the need for a stable…
Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody
COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are…
Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental…
Scanning electron microscopy-based energy dispersive X-ray spectroscopy (SEM-EDS) is proposed as a versatile tool for quantifying surface area coverage (SAC) by magnesium stearate (MgSt) on pharmaceutical tablets and particles. Our approach…
The impact of applying an additional polymer coating on high drug-loaded amorphous solid dispersions…
Inhibiting surface crystallization is an interesting strategy to enhance the physical stability of amorphous solid dispersions (ASDs), still preserving high drug loads. The aim of this study was to investigate the potential surface…
Extrusion 3D printing of minicaplets for evaluating in vitro & in vivo praziquantel delivery…
This study aimed to explore extrusion three dimensional (3D) printing technology to develop praziquantel (PZQ)-loaded minicaplets and evaluate their in vitro and in vivo delivery capabilities. PZQ-loaded minicaplets were 3D printed using a…
Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a…
The purpose of this study was to develop an oral paediatric formulation of budesonide (BUD) for the treatment of inflammatory bowel disease. A formulation realized as microspheres using the prilling/vibration technique is proposed as an…
Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation
Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to…
Design and Optimization of Lornoxicam Dispersible Tablets Using Quality by Design (QbD) Approach
The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical…
Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin
Compared to subcutaneous injections, oral administration of insulin would be a preferred route of drug administration for diabetic patients. For oral delivery, both liposomes and alginate hydrogels face many challenges, including early…
Development and Characterisation of a Topical Methyl Salicylate Patch: Effect of Solvents on…
The advent of skin patch formulation design and technology has enabled the commercialisation of methyl salicylate (MS) as a topical patch. However, the most fundamental aspect of skin permeation is unknown at present. The study aims to…
Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders
Soluplus is a polymer that has been explored to prepare nanocomposites for pulmonary drug delivery and is non-toxic. However, its aerosolization attributes when spray-dried have not been investigated. Hence, this work aimed to investigate…
In Situ Co-Amorphization of Olanzapine in the Matrix and on the Coat of Pellets
In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during…
Biocompatible phospholipid-based mixed micelles for posaconazole ocular delivery: Development,…
Current study intended to prepare and evaluate phospholipid-based, mixed micelles (MMs) to improve the ocular delivery of posaconazole (POS), a broad-spectrum antifungal drug. For this, MMs based on egg phosphatidylcholine (EPC), as the…
Clean label ingredients for solid oral dosage forms
In general, clean label is a consumer driven movement, demanding a return to real food and transparency through authenticity. For nutritional supplements, this means that they should contain natural, familiar, simple ingredients that are…
The effects of surfactants on the performance of polymer-based microwave-induced in situ…
Microwave-induced in situ amorphization is a novel technology for preparing amorphous solid dispersions (ASDs) to address the challenges of their long-term physical stability and downstream processing. To date, only few types of dielectric…
Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for…
Abstract
Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available…
Formulation Development and In Vitro–Ex Vivo Characterization of Hot-Melt Extruded Ciprofloxacin…
This study developed, optimized, characterized, and evaluated bioadhesive, hot-melt extruded (HME), extended-release ocular inserts containing ciprofloxacin hydrochloride (CIP-HCL) to improve the therapeutic outcomes of ocular bacterial…
Investigation of wound healing efficiency of multifunctional eudragit/soy protein isolate…
One significant aspect of the current therapeutic agents employed in wound healing involves the engineering of nano polymeric scaffolds to mimic the properties of extracellular matrix (ECM). The present work aimed to prepare and evaluate…
Enhancing oral bioavailability of andrographolide via sodium dodecyl sulfate and D-α-Tocopherol…
Nanocrystal technology is a common strategy to enhance the oral bioavailability of poorly-soluble drugs, and how to enlarge the enhancing ability on oral absorption via nanocrystals has become a pharmaceutical research field. In this study,…
Trehalose SG – Exosomes brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose SG
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and…
Solid microneedle assisted transepidermal delivery of iloperidone loaded film: Characterization and…
Transepidermal microneedle-assisted drug delivery is an alternative approach that can improve the therapeutic permeability of the drug in the deeper layers of the skin. The project aims to check the effect of a microneedle roller on…
Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous…
Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability…
Improving the Powder Properties of an Active Pharmaceutical Ingredient (Ethenzamide) with a Silica…
To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different…