Innovative Formulation Strategies for orodispersible Loratadine Dosage Forms
This poster was presented at EuPFI 2024 in Rotterdam.
Introduction
Loratadine, an antihistamine medication, is widely prescribed for the treatment of various allergic conditions in pediatric patients because of its efficacy in the treatment of allergic disorders. Considering the unique physiological and psychological needs of children,…
Recent approaches for enhancing the performance of dissolving microneedles in drug delivery…
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical and pharmaceutical applications. Being made of water-soluble…
COMBILOSE: A novel lactose-based co-processed excipient for direct compression
Lactose is the commonly used diluent in the manufacturing of tablets dosage form. However, the poor flowability and compressibility of lactose limit its use as a directly compressible filler binder. In this research work, composite…
A new oral self-emulsifying drug delivery system improves the antileishmania efficacy of…
The aim of this study was to develop, characterize and evaluate the in vivo oral efficacy of self-emulsifying drug delivery systems (SEDDS) containing fexinidazole (FEX) in the experimental treatment of visceral leishmaniasis (VL). The…
Formulation and Characterisation of Carbamazepine Orodispersible 3D-Printed Mini-Tablets for…
Abstract
One of the main challenges to paediatric drug administration is swallowing difficulties, hindering the acceptability of the medicine and hence clinical outcomes. This study aims at developing a child-appropriate dosage form, the…
Development of directly compressible formulations of Sitagliptin hydrochloride and Sitagliptin…
Direct compression is the simplest and most economical way to produce pharmaceutical tablets. Challenging API properties as e.g., poor powder flow or compactibility can limit or even restrict the use of direct compression technology. In…
Effect of Strength and Porosity of Tablets on the Magnitudes of Subdivision Forces
In this study, a hardness tester was modified by attaching a metal blade to its testing area to obtain the minimum forces required to subdivide tablets along their diameters (F’). Moreover, the tensile strengths of subdividing tablets (TS’)…
PHOSAL® H 50: Liquid Phospholipids Derived from Sunflower
The Natural All-Rounder
Lipoid’s PHOSAL® H 50 is a liquid formulation of purified phosphatidylcholine (PC) and oil from 100 % sunflower. This unique, pure and natural liquid formulation can serve as a solubilizer for lipophilic actives and…
Pharmaceutical polymers and P-glycoprotein: Current Trends and Possible Outcomes in Drug Delivery
Drug resistance is considered a key reason behind the failure of therapeutic medications for several chronic diseases, including hypertension, cancer therapeutics, and antimicrobial agents. Among the strategies used to overcome drug…
N-nitrosamine risk assessments for oral dosage forms: Nitrite content in the microcrystalline…
INTRODUCTION
The effects of N-nitroso compounds on human health (particularly their role in gastric cancer) are well known.1 Certain N-nitrosamines are described as highly probable human carcinogens. They are usually formed by the reaction…
Drop-on-powder 3D printing of amorphous high dose oral dosage forms: Process development,…
Drop-on-powder 3D printing is able to produce highly drug loaded solid oral dosage forms. However, this technique is mainly limited to well soluble drugs. The majority of pipeline compounds is poorly soluble, though, and requires solubility…
Particle-Based therapies for antigen specific treatment of type 1 diabetes
Type 1 diabetes mellitus (T1D) is the leading metabolic disorder in children worldwide. Over time, incidence rates have continued to rise with 20 million individuals affected globally by the autoimmune disease. The current standard of care…
A Novel Approach of External Lubrication in a Rotary Tablet Press Using Electrostatics
Abstract
Purpose
In powder compaction on rotary tablet presses, the addition of a lubricant is normally mandatory. However, the typical internal lubrication method tends toward overlubrication, resulting in an alteration of the…
Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based…
Triamcinolone acetonide (TA) is a corticosteroid that has been used to treat posterior segment eye diseases. TA is injected intravitreally in the management of neovascular disorders; however, frequent intravitreal injections result in many…
Development and Evaluation of Vaginal Suppository Containing Althaea officinalis L. Polysaccharide…
Abstract
Intrauterine adhesions cause several gynecological problems. Althaea officinalis L. roots known as marshmallows contain polysaccharides (M.P.) which possess anti-inflammatory and anti-ulcerogenic activities also can form a…
RGD-decorated PLGA nanoparticles improved effectiveness and safety of cisplatin for lung cancer…
Upon extensive pharmaceutical and biomedical research to treat lung cancer indicates that lung cancer remains one of the deadliest diseases and the leading cause of death in men and women worldwide. Lung cancer remains untreated and has a…
Engineering the right formulation for enhanced drug delivery
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules and biologics and offer several advantages for inhaled therapy. Early DPI products were intended to treat asthma and lung chronic inflammatory disease…
Innovative lipids for Your Nucleic Acid Delivery research
The history and evolution of Nucleic Acid Delivery systems
mRNA and liposomes were both first discovered in the 1960s, and liposomes were used to deliver mRNA into eukaryotic cells in 1978.1,2 Even with the ability to inject mRNA into…
Dissolvable microneedles for transdermal drug delivery showing skin pentation and modified drug…
Topical therapies for chronic skin diseases suffer from a low patient compliance due to the inconvenient treatment regimens of available products. Dissolvable microneedles (MN) with modified release offer an interesting possibility to…
Co-Crystallization Approach to Enhance the Stability of Moisture-Sensitive Drugs
Stability is an essential quality attribute of any pharmaceutical formulation. Poor stability can change the color and physical appearance of a drug, directly impacting the patient’s perception. Unstable drug products may also face loss of…
Development of spray-dried N-acetylcysteine dry powder for inhalation
N-acetylcysteine (NAC) has both antioxidant and immunomodulatory activities and has been used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its possible role in reducing the affinity of the spike…
Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments…
Clarithromycin and Pantoprazole Gastro-Retentive Floating Bilayer Tablet for the Treatment of…
Bilayer/multilayer tablets have been introduced to formulate incompatible components for compound preparations, but they are now more commonly used to tailor drug release. This research aimed to formulate a novel gastro-retentive tablet to…
Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal…
In our present series of experiments, we investigated the nasal applicability of the previously developed Soluplus® - Meloxicam polymeric micelle formulation. Utilizing the nasal drug investigations, moderately high mucoadhesion was…
Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients
Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is associated with adverse effects. If these excipients are rapidly degraded to endogenously occurring metabolites such as amino acids and
fatty…
Direct cyclodextrin based powder extrusion 3D printing of budesonide loaded mini-tablets for the…
The purpose of this study was to combine direct powder extrusion (DPE) 3D printing and fluid bed coating techniques to create a budesonide (BD) loaded solid oral formulations for the treatment of eosinophilic colitis (EC) in paediatric…
Improving drug release rate, drug-polymer miscibility, printability and processability of FDM…
Slow drug release, low drug-polymer miscibility, poor printability of polymers used, and high processing temperature are major challenges in developing FDM 3D-printed tablets. These challenges were addressed in this investigation by having…
Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery
Abstract
Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and…
Effect of Penetration Enhancers on Transdermal Delivery of Oxcarbazepine, an Antiepileptic Drug…
Oxcarbazepine (OXC) is an anticonvulsant drug, indicated for the treatment of the neurological disorder, epilepsy. The objective of the present study was to evaluate the transdermal delivery of OXC from microemulsions using different…
Apinovex Polymers Enable Solubility With Ease
Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your…
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs
PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low…
Evaluation of alternative methods to derive particle density from compression data
The determination of particle density is a critical part of material characterization regarding compression analyses. Helium pycnometry as the most commonly used method is criticized for different aspects. Most prominent is the…
Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable…
Low bone mass, degeneration of bone tissue, and disruption of bone microarchitecture are all symptoms of the disease osteoporosis, which can decrease bone strength and increase the risk of fractures. The main objective of the current study…
Surge in demand for patient-centric dosage forms
From minitablets to stick-packs: BENEO’s filler-binder galenIQ™ makes it easy for manufacturers to meet a growing need for convenient paediatric and geriatric delivery formats
Different consumer groups have different requirements. The…
Design and optimization of ciprofloxacin hydrochloride biodegradable 3D printed ocular inserts: Full…
Coupling hot-melt extrusion (HME) with fused deposition modeling three-dimensional printing (FDM-3DP) can facilitate the fabrication of tailored, patient-centered, and complex-shaped ocular dosage forms. We fabricated ciprofloxacin HCl…