Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Shifting from sustained to delayed drug delivery systems: Encapsulated mesoporous silica-chitosan…
The current study demonstrates a desired drug delivery-controlled system with a wide range of release parameters. It illustrates the feasibility of carriers in the systems for extended and short drug release. Herein, mesoporous silica…
Design and development of a chitosan-based nasal powder of dimethyl fumarate-cyclodextrin binary…
The nasal administration route has been studied for the delivery of active molecules directed to the Central Nervous System, thanks to the anatomical connection between the nasal cavity and the brain.
Dimethyl fumarate is used to treat…
Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic…
Abstract
Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more…
Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line…
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
Introduction
A Process Analytical Technology (PAT) strategy for process and product…
Nanocarriers for Controlled Release and Target Delivery of Bioactive Compounds
See the new book, edited by Shaba Noore , Shivani Pathania , Pablo Fuciños , Colm P. O'Donnell , Brijesh K. Tiwari.
Description: This brief provides a comprehensive overview of nanocarriers used for nanoencapsulation of bioactive…
WHO good manufacturing practices considerations for the prevention and control of nitrosamine…
The WHO has published a new draft guideline on considerations for the prevention and control of nitrosamine contamination in pharmaceutical products. This guideline applies to all manufacturers of excipients, active pharmaceutical…
Transfer of a rational formulation and process development approach for 2D inks for pharmaceutical…
The field of pharmaceutical 3D printing is growing over the past year, with Spitam® as the first 3D printed dosage form on the market. Showing the suitability of a binder jetting process for dosage forms. Although the development of inks…
Update: Risk Mitigation of Nitrosamines Formation in Drug Products: Role of Excipients
1. Introduction
The issue of Nitrosamine impurities in drug and excipient manufacturing has become a significant concern for the pharmaceutical industry and health authorities. In June 2018, the FDA was notified of the presence of…
Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine…
Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass metabolism in the…
Opportunities and Challenges: Process Raman for the Real-Time Release Testing (RTRT) of…
Abstract
The use of a process analytical technology has been demonstrated using near-infrared spectroscopy for continuous manufacturing of pharmaceutical formulations and is within the scope of the U.S. Food and Drug Administration's…
Risperidone/cyclodextrin inclusion complex electrospun nanofibers for fast-disintegrating…
In this paper, the inclusion complexes (ICs) of hydroxypropyl-beta-cyclodextrin (HPβCD) and risperidone were electrospun into nanofibrous film for potential fast-disintegrating drug delivery system. Risperidone is used to treat bipolar…
Controlled Release: Timing is Everything
IFF officially release a new Controlled release platform on 15th of May 2024. Here you get a deeper insight in the "Timing is Everything" platform where you can learn about pharmaceutical formulations to benefit patients and the importance…
STYL’One Nano – The Most Advanced Benchtop Tablet Press
THE NEW STYL’ONE NANO is a revolutionary benchtop R&D press for demanding formulation and scientists with price performance in mind.
Instruments for every formulation scientist with price performance in mind
POWDER COMPACTION SCIENCE…
L-HPC – Multifunctional excipient for oral solid dose by Shin-Etsu
L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) was developed by Shin-Etsu and first approved in 1977 as a disintegrant for tablets in Japan. New grades were developed during the last years in order to cover the needs for our…
Nano-encapsulation of probiotics: Need and critical considerations to design new non-dairy probiotic…
People worldwide need to improve their health or intention to control diseases more naturally through ingredients incorporated into foods and beverages, called functional foods. Functional foods include probiotic organisms and bioactive…
In Situ Gelling Nasal Drug Delivery System
Abstract
In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the drug is high as compared to other routes, as well as has increased good bioavailability of drugs at the systemic circulation. To…
Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory…
Abstract
Active pharmaceutical ingredients (APIs) and excipients can be carefully combined in premix-based materials before being added to dosage forms, providing a flexible platform for the improvement of drug bioavailability, stability,…
Enabling Stable and Directly Compressible Probiotic Tablet Formulations with a Novel Co-processed…
This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
The growing interest in probiotic supplements is driven by the…
Development of novel portable NIR spectroscopy process analytical technology (PAT) tool for…
The aim of this research was to develop a process analytical technology (PAT) tool for monitoring the transformation process of the active ingredient ibuprofen into the fast-dissolving salt ibuprofen sodium during the wet granulation…
Enhancing breast cancer treatment: Comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed…
Abstract
Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel therapeutic approaches. Key players in the regulation of apoptosis, a fundamental process in cell…
Electromagnetic drop-on-demand (DoD) technology as an innovative platform for amorphous solid…
Production of amorphous solid dispersions (ASDs) is an invaluable technique to promote the solubility and bioavailability of medicinal substances. ASD is manufactured using a variety of classic and modern techniques, most of which rely on…
A comprehensive assessment of machine learning algorithms for enhanced characterization and…
Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast…
WHO recommends risk management plans for high-risk excipients
The World Health Organization (WHO) has released two draft appendices to a recent draft guideline on good manufacturing practices (GMPs) for excipients. The first document recommends manufacturers develop risk management plans for…
IFF Unveils its Controlled Release Platform Featuring its Innovation and Trailblazing Excipients
PRESS RELEASE
NEW YORK —May 15, 2024 — IFF (NYSE: IFF), a global leader in food and beverage, home and personal care and health, today announced a new controlled release platform for its portfolio of controlled release products…
Spray drying Eudragit® E-PO with acetaminophen using 2- and 3-fluid nozzles for taste masking
Conventional spray drying using a 2-fluid nozzle forms matrix microparticles, where drug is distributed throughout the particle and may not effectively mask taste. In contrast, spray drying using a 3-fluid nozzle has been reported to…
Fabrication and evaluation of stable amorphous polymer-drug composite particles via a nozzle-free…
Abstract
We present a promising method for producing amorphous drug particles using a nozzle-free ultrasonic nebulizer with polymers, specifically polyvinylpyrrolidone (PVP), poly(acrylic acid) (PAA), and Eudragit® S 100 (EUD). Model…
Fine excipient materials in carrier-based dry powder inhalation formulations: The interplay of…
Abstract
The contributions of fine excipient materials to drug dispersibility from carrier-based dry powder inhalation (DPI) formulations are well acknowledged, although they are not fully elucidated. To improve the understanding of…
METOLOSE® – Binder and Thickening Agent
Hydroxy propyl methyl cellulose (Hypromellose) and methyl cellulose are produced by Shin-Etsu Chemical Co., Ltd. since 1960s under the trade name METOLOSE®. For methyl cellulose, several grades are available, and they differ in…
Nanostructured Lipid Carriers for Oral Treatment of Leishmaniasis: Design and Preclinical Evaluation
Pentavalent antimonials are the primary treatment for leishmaniasis due to their proven efficacy and cost-effectiveness. However, they present poor oral absorption, parenteral administration, and serious adverse effects due to prolonged…
Selection of lubricant type and concentration for orodispersible tablets
Abstract
Lubricants are essential for most tablet formulations as they assist powder flow, prevent adhesion to tableting tools and facilitate tablet ejection. Magnesium stearate (MgSt) is an effective lubricant but may compromise tablet…
A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages…
Abstract
Although 2D cancer models have been the standard for drug development, they don't resemble in vivo properties adequately. 3D models can potentially overcome this. Bioprinting is a promising technique for more refined models to…
BASF Biopharma Ingredients Portfolio – High Quality Raw Materials for Biopharmaceutical…
Biopharmaceutical manufacturing processes require high-quality raw materials delivered through a transparent and reliable supply chain, supported by experts. BASF Biopharma Ingredients is committed to meeting your requirements for every…
Batch vs. continuous direct compression – a comparison of material processability and final tablet…
Abstract
In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated.…
Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a…
Addressing poor solubility and permeability issues associated with synthetic drugs and naturally occurring active compounds is crucial for improving bioavailability. This review explores the potential of phospholipid complex formulation…