Innovative Formulation Strategies for orodispersible Loratadine Dosage Forms
This poster was presented at EuPFI 2024 in Rotterdam.
Introduction
Loratadine, an antihistamine medication, is widely prescribed for the treatment of various allergic conditions in pediatric patients because of its efficacy in the treatment of allergic disorders. Considering the unique physiological and psychological needs of children,…
Nano-delivery systems for encapsulation of phenolic compounds from pomegranate peel
Pomegranate fruit is getting more attention due to its positive health effects, and pomegranate peel (PP) is its main byproduct. PP has the potential to be converted from environmentally polluting waste to wealth due to its rich phenolic…
Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where…
While the global market for veterinary products has been expanding rapidly, there is still a lack of specialist knowledge of equine pharmaceutics. In many cases, the basic structure of the gastrointestinal tract (GIT) and integumentary…
Incorporating a Lipophilic Disulfide-Bridged Linoleic Prodrug into a Self-Microemulsifying Drug…
The oral absorption of paclitaxel (PTX) is restricted by poor solubility in the gastrointestinal tract (GIT), low permeability, and high first-pass metabolism. Lipid carriers, such as a self-microemulsifying drug delivery system (SMEDDS),…
Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of…
Abstract
This review is devoted to modern systems of nanocarriers that ensure the targeted delivery of flavonoids to various organs and systems. Flavonoids have wide range of effects on the human body due to their antioxidant,…
Processability and Oral Bioavailability Improvement of Itraconazole by Particle Engineering…
The current study aimed to improve the processability and oral bioavailability of itraconazole (ITZ) via spherical agglomeration. ITZ-spherical agglomerates (ITZ-SA) and ITZ-poloxamer 407-spherical agglomerates (ITZ-PLX-SA) were optimized…
Formulation and Skin Permeation of Active-Loaded Lipid Nanoparticles: Evaluation and Screening by…
Encapsulation into nanoparticles (NPs) is a potential method to deliver pharmaceutical/cosmetic actives deep into the skin. However, understanding the NP formulations and underlying mechanism of active delivery to skin has scarcely been…
Safety of Soluplus® in Pediatrics
This paper provides information on the risk and acceptability of the polymeric solubilizer Soluplus® as an excipient in pediatric formulations. The assessment was performed based on safety data available from the manufacturer and publicly…
Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen…
This work developed high drug-load pellets for colon targeting in minimal steps by coupling hot-melt extrusion (HME) with a die-surface cutting pelletizer, offering a potential continuous pellet manufacturing process. Ketoprofen (KTP) was…
Controlled drug delivery mediated by cyclodextrin-based supramolecular self-assembled carriers: From…
The need for solutions in the pharmaceutical field that respond to the new needs regarding the minimum impact of the active pharmaceutical substances on the body has led to an explosion of research on smart systems for controlled drug…
Temperature Cycling-Induced Formation of Crystalline Coatings
The surface of particles is the hotspot of interaction with their environment and is therefore a major target for particle engineering. Particles with tailored coatings are greatly desired for a range of different applications. Amorphous…
Screening of lubricants towards their applicability for external lubrication
Internal lubrication is associated with decreasing tensile strength and prolonged disintegration. These effects can be minimized using external lubrication. In current study, six lubricants (magnesium stearate, sodium stearyl fumarate,…
The Quest for Child-Friendly Carrier Materials Used in the 3D Semi-Solid Extrusion Printing of…
This work gives a brief overview of carrier materials currently used in pharmaceutical studies on the three-dimensional (3D) semi-solid extrusion (SSE) printing of medicines for pediatrics. The suitability of using these carrier materials…
A Review on Taste Masked Multiparticulate Dosage Forms for Paediatric
Taste refers to those sensations perceived through taste buds on the tongue and oral cavity. The unpleasant taste of drugs leads to the refusal of taking the medicine in the paediatric population. It is widely known that a pharmaceutical…
Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures
The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing…
Solid dispersions of atorvastatin with Kolliphor RH40: Enhanced supersaturation and improvement in a…
Atorvastatin is a potent lipid-lowering drug with poor solubility and high presystemic clearance that limits its therapeutic efficacy. The aim of this study was to develop solid dispersions and micellar systems to obtain fast-dissolving…
Preparation, characterization, and in vitro release of microencapsulated essential oil…
Oregano essential oil (EO)–loaded pellets were prepared using calcium phosphate substrates of different specific surface areas (Sw) and as binders EO in water emulsions with low or high EO content, stabilized with polysaccharides (PSC) or a…
FDA-Approved Small Molecules in 2022: Clinical Uses and Their Synthesis
This review describes the recently FDA-approved drugs (in the year 2022). Many of these products contain active moieties that FDA had not previously approved, either as a single ingredient or as part of a combination. These products…
Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose…
Inkjet printing has the potential to advance the treatment of eye diseases by printing drugs on demand onto contact lenses for localised delivery and personalised dosing, while near-infrared (NIR) spectroscopy can further be used as a…
Quality by design approach with multivariate analysis and artificial neural network models to…
Purpose
Although understanding the variability in the physicochemical properties of an excipient in a drug formulation is becoming an important aspect of the quality by design approach, few studies have reported the effect of excipient…
Development of 3D-printed vaginal devices containing metronidazole for alternative bacterial…
Bacterial vaginosis (BV) is an abnormal condition caused by the change of microbiota in the vagina. One of the most common bacteria found in the case of BV is Gardnerella vaginalis, which is categorised as anaerobic facultative bacteria.…
In Situ Encapsulation of Biologically Active Ingredients into Polymer Particles by Polymerization in…
The encapsulation of biologically active ingredients (e.g., peptides, proteins, enzymes, drugs) into polymer particles is extensively used for drug delivery purposes. However, this strategy relies mainly on emulsification processes from…
Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of…
Objective: Development and evaluation of bucco-adhesive films of Gliclazide for pediatric use.
Methods: Sixteen films were formulated using a different combination of Gelatin, Hydroxy propyl methyl cellulose (HPMC), polyvinyl alcohol,…
Excipient Taxonomy for the 21st Century
The performance of pharmaceutical dosage forms relies heavily on the characteristics of the excipients that are incorporated into the drug product during the manufacturing process. Therefore, it is imperative that formulators are able to…
The role of excipients in promoting topical and transdermal delivery: Current limitations and future…
Topical and transdermal delivery has historically offered an attractive and non-invasive route for administration of medicines. However, human skin is known to be a remarkably good barrier to the permeation of substances. The majority of…
Optimized L-SNEDDS and Spray-Dried S-SNEDDS Using a Linked QbD-DM3 Rational Design for Model…
A QbD-DM3 strategy was used to design ketoprofen (KTF) optimized liquid (L-SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS). Principal component analysis was used to identify the optimized L-SNEDDS containing Capmul®…
Comparative study on the topical and transdermal delivery of diclofenac incorporated in…
Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The lack thereof would…
Improving aqueous solubility of paclitaxel with polysarcosine-b-poly(γ-benzyl glutamate)…
New stealth amphiphilic copolymers based on polysarcosine (PSar) rather than poly(ethylene glycol) (PEG) have gained more attention for their use as excipients in nanomedicine. In this study, several polysarcosine-b-poly(γ-benzyl glutamate)…
Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide
The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less…
New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid…
Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs are based on an amorphous API dispersed in a polymer, and their stability…
Improving in vivo oral bioavailability of a poorly soluble drug: a case study on polymeric versus…
Poorly soluble drugs must be appropriately formulated for clinical use to increase the solubility, dissolution rate, and permeation across the intestinal epithelium. Polymeric and lipid nanocarriers have been successfully investigated for…
Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics
Abstract
Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation…
Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles…
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately,…
Compatibility Study between Fenbendazole and Polymeric Excipients Used in Pharmaceutical Dosage…
The body of work described in this research paper evaluates the compatibility between Fenbendazole (Fen), which is a broad-spectrum anthelmintic with promising antitumor activity, and three polymeric excipients commonly applied in…
Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease
Abstract
Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the…