Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Nontoxic Natural Polymeric Particle Vehicles Derived from Hyaluronic Acid and Mannitol as Mitomycin…
Hyaluronic acid/mannitol (HA/MN)-based particles were designed as mitomycin c (MMC) delivery vehicles through the crosslinking of 1:0, 3:1, 1:3, and 0:1 mole ratios of HA/MN to investigate their potential use in bladder cancer therapy. The…
Formulation development and evaluation of Transdermal patch of Astaxanthin
Transdermal patches are the cutting-edge drug delivery approach that may be utilized to bypass hepatic first-pass metabolism and to increase absorption for effective systemic effects. By using HPMC, Eudragit L-100, Plasticizer, and…
Novel Approach to Pharmaceutical 3D-Printing Omitting the Need for Filament—Investigation of…
The utilized 3D printhead employs an innovative hot-melt extrusion (HME) design approach being fed by drug-loaded polymer granules and making filament strands obsolete. Oscillatory rheology is a key tool for understanding the behavior of a…
Development, Quality by Design-Based Optimization, and Stability Assessment of Oral Liquid…
The absence of oral liquid pharmaceutical forms appropriate for use in pediatric and adult patients with difficulty swallowing is a public health problem, especially in the hospital context. Baclofen is a muscle relaxant of choice for…
Ring inserts as a useful strategy to prepare tip-loaded microneedles for long-acting drug delivery…
The role of microneedle array patches (MAPs) and, in particular, dissolving MAPs in transdermal drug delivery has increased exponentially over the last decade. MAPs are able to form drug depots in the viable skin from where poorly soluble…
Sepifilm NATurally COLored
Film-coating agent formulated without TiO2, aluminium and artificial colors
Current solutions in tablet coating make it hard to both meet the growing demand for naturalness from consumers and to comply with stricter regulations, especially…
Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous…
Lumefantrine, exhibits poor bioavailability due to its very low solubility. A liquisolid compact of lumefantrine was prepared with mesoporous silica as a novel coating material. Lactose anhydrous and syloid 244FP were selected as carrier…
Drug Physicochemical Properties and Capsule Fill Determine Extent of Premature Gastric Release from…
Intrinsically, enteric capsule shells offer several advantages compared to coating of dosage forms with enteric polymers. We undertook a systematic investigation to elucidate capsule-fill parameters that may result in premature gastric drug…
The Formula For Stability – High-quality excipients for your plasma-derived products
Quality for your formulation, stability for your products.
To solve the challenge of stability requirements in plasma applications, we offer a wide range of high-quality pharmaceutical excipients that allow you to formulate and…
A Review of Various Manufacturing Approaches for Developing Amorphous Solid Dispersions
In recent years amorphous solid dispersions (ASD) has gained a tremendous response for improving the solubility of poorly water-soluble drug substances. Despite the stability challenges, various ASD commercial products have been…
Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications
Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility…
Solventless amorphization and pelletization using a high shear granulator. Part II; Preparation of…
The aim of this study was to investigate the preparation of co-amorphous mixture-layered pellets using solventless pelletization and amorphization using a high shear granulator (as suggested in the first part of this study) by high shear…
LUBRITAB RBW – The Clean Label Lubricant for Tablet and Capsule Formulations
LUBRITAB® RBW (Rice Bran Wax) is the innovative all-natural lubricant designed to meet growing clean label demands. Derived from rice, this plant-based ingredient is gluten-free, and offers a sustainable solution for tablet and capsule…
Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous…
Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of…
Solventless amorphization and pelletization using a high shear granulator. Part I; feasibility study…
The aim of the current study was to investigate the feasibility of solventless amorphization and pelletization using a high shear granulator, to produce amorphous drug-layered pellets by simply mixing drug crystals and inactive spheres…
AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and…
Formulation and Evaluation of Olmesartan Medoxomil Tablets
This work proposes a methodology for the design, development, and characterization of tablets prepared by the direct compression method of olmesartan medoxomil. The main objective was to ensure a high dissolution rate of the active…
Amphotericin B- and Levofloxacin-Loaded Chitosan Films for Potential Use in Antimicrobial Wound…
Levofloxacin (LVX) and amphotericin B (AMB) have been widely used to treat bacterial and fungal infections in the clinic. Herein, we report, for the first time, chitosan films loaded with AMB and LVX as wound dressings to combat…
Processing of Lipid Nanodispersions into Solid Powders by Spray Drying
Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve…
Update of IPEC Guide Certificate of Analysis for Pharmaceutical Excipients
The International Pharmaceutical Excipients Council Federation, (IPEC Federation) announces the availability of the updated IPEC Certificate of Analysis Guide for Pharmaceutical Excipients (Version 2, 2022). The guide was originally…
Neither too little nor too much: finding the ideal proportion of excipients using confocal Raman and…
The applications of Raman imaging in pharmaceutical field are ever-increasing due its ability to obtain spatial and spectral information simultaneously, once it allows determine the chemical distribution of compounds. In this sense, it is…
What is pHmicroenvironment (or pHm)?
See the last "salts" video from Pharma Drama, aka Prof. Simon Gaisford or read the video transcript below:
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’m going…
Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation…
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems,…
Design And Optimization of Midazolam Loaded Microemulsion Using Quality by Design (Qbd) Assisted…
Abstract
Introduction: More emphasize was given in the present work is application of QbD tools and DoE approach. The existing study was aimed towards development and characterization of Midazolam (MZM) loaded microemulsion (ME) for brain…
Trehalose SG – For DNA/RNA Stabilization brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose SG
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and…
Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including…
Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis
Abstract
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease with unknown cause. It mainly affects joints and, without proper treatment, negatively impacts their movement, causes painful deformities, and reduces the…
TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems
Liposomes are sphere-shaped vesicles that can capture therapeutics either in the outer phospholipid bilayer or inner aqueous core. Liposomes, especially when surface-modified with functional materials, have been used to achieve many…
A New Method to Determine Drug-Polymer Solubility Through Enthalpy of Melting and Mixing
In this study, a new method to determine the solubility of crystalline drugs in (amorphous) polymers is proposed. The method utilizes annealing of supersaturated amorphous solid dispersions to achieve equilibrium between dissolved and…
Topical delivery of Bruton’s tyrosine kinase inhibitor and curcumin-loaded nanostructured lipid…
This work investigates the synergistic potential of the nanostructured lipid carrier (NLC) gel of Ibrutinib with Curcumin as a repurposing strategy to treat psoriasis. In the present work, various components such as liquid lipid, solid…
Impact of Aluminum Oxide Nanocoating on Drug Release from Amorphous Solid Dispersion Particles
Atomic layer coating (ALC) is emerging as a particle engineering strategy to inhibit surface crystallization of amorphous solid dispersions (ASDs). In this study, we turn our attention to evaluating drug release behavior from ALC-coated…
Use of high melting point solid vegetable oils in encapsulation processes – ADM White Paper
Use of high melting point solid vegetable oils in encapsulation processes
Introduction to encapsulation
Encapsulation relates to technologies that enable the incorporation of a compound into individualized small
particles.…
Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization…
BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon® VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion…
The role of hydrophilic/hydrophobic group ratio of polyvinyl alcohol on the miscibility of…
The miscibility of the therapeutic drug in the polymer matrix is the key to the successful design and development of orodispersible films (ODFs). In the present study, four hydrolyzed polyvinyl alcohols (PVAs) with identical polymerization…