Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
The role of hydrophilic/hydrophobic group ratio of polyvinyl alcohol on the miscibility of…
The miscibility of the therapeutic drug in the polymer matrix is the key to the successful design and development of orodispersible films (ODFs). In the present study, four hydrolyzed polyvinyl alcohols (PVAs) with identical polymerization…
Formulation development, optimization and characterization of Pemigatinib-loaded supersaturable…
Background
Pemigatinib is a small molecule tyrosine kinase inhibitor of fibroblast growth factor receptor inhibitors. The oral bioavailability of Pemigatinib is constricted due to its limited solubility at physiological pH. It is essential…
Hayashibara Maltose PH – For Culture Media
Hayashibara ― A world leading supplier of pharmaceutical grade Maltose PH
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and…
Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmetic applications
The progress in new delivery systems for active ingredients has boosted the dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin permeation capabilities. Cyclodextrins (CDs) are cyclic oligosaccharides…
Electrospinning as a method for preparation of redispersible dry product with high content of…
One of the key technological challenges in the development of iron-oxide-based magnetic nanoparticles (MNPs) is their long-term physical stability in colloidal dispersions. This can be improved by their transformation into a dry form. Here,…
Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for…
Despite being recognized as the “gold standard” for treating azole-resistant vulvovaginal candidiasis, amphotericin B (AmB), an amphoteric molecule, has not been widely used due to serious issues with solubility and permeability. In light…
Development and assessment of phospholipid-based luteolin-loaded lipid nanocapsules for skin…
Luteolin is an excellent flavone possessing several beneficial properties such as antioxidant and anti-inflammatory effects which are interesting for skin delivery. Development of an appropriate skin delivery system could be a promising…
Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer’s Drugs
Abstract
Alzheimer’s disease (AD) is the most common form of dementia, with a high impact worldwide, accounting for more than 46 million cases. The continuous increase of AD demands the fast development of preventive and curative…
Control Strategy for Excipient Variability in the Quality by Design Approach Using Statistical…
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is…
Applicability of Co processed Excipient to ODT prepared by Direct Compression Continuous…
Introduction
Continuous Manufacturing (CM) is a manufacturing method in which raw materials or blended materials enter the manufacturing process continuously, and products are discharged continuously throughout the duration of the…
Fused Deposition Modeling (FDM) 3D Printing of the Thermo-Sensitive Peptidomimetic Drug Enalapril…
Fused deposition modeling (FDM) 3D printing was used to produce 3D printed tablets with the thermo-sensitive model peptidomimetic drug enalapril maleate (EM). Two different formulations were prepared to investigate the degradation of…
Preparation and Evaluation of Directly Compressible Orally Disintegrating Tablets of Cannabidiol…
This study demonstrated the implementation of a liquisolid technique to formulate directly compressible orally disintegrating tablets (ODTs). Cannabidiol (CBD), a hydrophobic cannabinoid, was prepared as a liquisolid powder using…
JRS PHARMA Announces New Clean Label Excipient LUBRITAB® RBW
Patterson, NY USA, November 2022 - JRS PHARMA proudly introduces its newest all-natural excipient: LUBRITAB® RBW. Developed as a lubricant for tablet and capsule formulations, LUBRITAB® RBW is suitable for use in direct compression and…
Formulate Robust, Fast Disintegrating Tablets with polyplasdone® crospovidone – Webinar
Do you want to learn how to optimize immediate release formulations in terms of disintegration performance?
Then register for our next free webinar:
Formulate Robust, Fast Disintegrating Tablets with polyplasdone® crospovidone.
Due to…
High-Shear Wet Granulation of SMEDDS Based on Mesoporous Carriers for Improved Carvedilol Solubility
Mesoporous carriers are a convenient choice for the solidification of self-microemulsifying drug delivery systems (SMEDDS) designed to improve the solubility of poorly water-soluble drugs. They are known for high liquid load capacity and…
Selecting the most appropriate formulation excipient for manufacture of amorphous solid dispersions:…
This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in the early stage of amorphous solid dispersion (ASD) system development by profiling the excipients’ capability to…
In Vitro and In Vivo Effect of pH-Sensitive PLGA-TPGS-Based Hybrid Nanoparticles Loaded with…
Doxorubicin (DOX) is an antineoplastic agent clinically employed for treating breast cancer patients. Despite its effectiveness, its inherent adverse toxic side effects often limit its clinical application. To overcome these drawbacks,…
Redox responsive poly(allylamine)/eudragit S-100 nanoparticles for dual drug delivery in colorectal…
Herein, we report redox responsive, colon cancer targeting poly(allylamine) (PA)/eudragit S-100 (EU) nanoparticles (PAEU NPs) (≈59 nm). These disulfide crosslinked PAEU NPs are developed via air oxidation of thiolated PA and thiolated EU,…
Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel…
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet relatively few comprehensive reviews specific to…
Oral self-emulsifying nanoemulsion systems for enhancing dissolution, bioavailability and anticancer…
This research aimed to prepare a camptothecin (CPT) loaded self nano emulsifying drug delivery system (SNEDDS) that would improve the oral therapeutic efficacy of CPT. 32 full factorial design was employed, and the effect of the amount of…
Omyanutra 300 – A highly compactable porous mineral ingredient
Omya proudly present their new excipient product portfolio : "Omyanutra 300". See the first product in the Portfolio:
Omyanutra 300
A New Generation of Excipients
Nutraceutical formulations consist of a multitude of active…
Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for…
The study was initiated with two major purposes: investigating the role of isomalt (GIQ9) as a pharmaceutical carrier for solid self-nanoemulsifying drug delivery systems (S-SNEDDSs) and improving the oral bioavailability of lipophilic…
Use of shear sensitive coloured guest component to track powder mixing in adhesive binary mixtures
The mixing performance in binary powder blends with components exhibiting guest and host type interactions was assessed by tracking the colour change of the mixture. The operation parameters like mixing time and speed were studied in…
Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet…
Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process…
Days or Centuries? – Predicting the Shelf-Life of ASDS
PURPOSE
Amorphous solid dispersions (ASDs) are a state-of-the-art enabling formulation technique for poorly water-soluble drugs. Drug recrystallization in the polymer matrix highly unwanted: marks end of shelf life of such a formulation.…
What is pHmax?
Salt chemistry is pretty complicated, and one of the more abstract concepts to understand is pHmax! Here, Pharma Drama looks at what pHmax is and what changes a salt will undergo on either side of it. This knowledge is super-useful when…
Nitrocellulose blister material as a source of N-nitrosamine contamination of pharmaceutical drug…
The recent focus of pharmaceutical regulatory authorities has been oriented towards the mitigation of carcinogenic N-nitrosamines in drug products and different sources of N-nitrosamines have been revealed. Within this work, the elucidation…
Strategies for 3D bioprinting of spheroids: A comprehensive review
Biofabricated tissues have found numerous applications in tissue engineering and regenerative medicine in addition to the promotion of disease modeling and drug development and screening. Although three-dimensional (3D) printing strategies…
Cyclodextrin-based ocular drug delivery systems: A comprehensive review
Cyclodextrin (CD), a class of cyclic oligosaccharides with an external hydrophilic surface and a central hydrophobic cavity is recognized as a promising pharmaceutical excipient due to its unique ability to form inclusion complexes with…
Ophthalmics Process by Merck – Keep a close eye on quality and safety
Reduce risk and overcome challenges
Ophthalmic drugs pose special formulation challenges to manufacturers. In general, choosing the right processes and materials is important to ensure the required quality, drug tolerability and patient…
Effect of Precirol ATO5 concentration and twin-screw melt granulation temperature on the physical…
SUMMARY
The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size…
Metamorphosis of Twin Screw Extruder-Based Granulation Technology: Applications Focusing on Its…
In order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing using continuous manufacturing (CM) and automated model-based control is being thought…
Disk-shaped compact tension test for fracture analysis on pharmaceutical tablets
Pharmaceutical tablets must meet a number of requirements and among them, the mechanical strength plays an important role. The diametral compression test is generally used to evaluate it but can generate unstable failures. Thanks to…
Sex-specific effects of excipients on oral drug bioavailability
The mechanism of action of excipients eliciting sex differences in drug bioavailability is poorly understood. In this study, the excipients Cremophor RH 40 (PEG 40 hydrogenated castor oil), Poloxamer 188 (2-methyloxirane) and Tween 80…