Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Elucidation of the effect of added fines on the performance of dry powder inhalation formulations
Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is an established strategy to improve aerosolization…
What is a salt?
The majority of drugs (around 60%) are formulated as a salt. This says salts are important! But why? And what are they exactly? Here, PharmaDrama aka Prof. Simon Gaisford discusses the basic definition of a salt, how they are formed and why…
Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are…
Effect of Glyceryl Monoolein Addition on the Foaming Properties and Stability of Whipped Oleogels
Medium Chain Triglyceride (MCT) oil was successfully combined with Glyceryl Monostearate (GMS) and Glyceryl Monoolein (GMO) to form oleogels that were subsequently whipped to form stable oleofoams. The co-crystallization of GMS and GMO at a…
Trends in development and quality assessment of pharmaceutical formulations – F2α analogues in…
The ocular delivery route presents a number of challenges in terms of drug administration and bioavailability. The low bioavailability following topical ophthalmic administration shows that there is a clear need for in-depth research aimed…
Emulsification by vitamin E TPGS or Quillaja extract enhanced absorption of berberine without…
Berberine is widely used for the prevention of cancers and diabetes. However, the absorption rate of berberine is less than 1% in humans. The objective of this research was to determine whether emulsification improves the absorption and…
Solid lipid nanoparticles: a promising tool for insulin delivery
Introduction
Insulin plays a critical role in metabolism modulation including carbohydrate, lipid, and protein metabolism. There is room to improve insulin delivery but optimizing the best carrier remains challenging. Traditional and…
Simultaneous modeling prediction of three key quality attributes of tablets by powder physical…
Tensile strength (TS), solid fraction (SF), and tablet weight variability (TWV) are all key quality factors to be considered during the tablet manufacturing process. For predicting them, a novel powder texture measurement methodology was…
The impact of lactose type on disintegration: An integral study on porosity and polymorphism
Besides factors such as disintegrant and lubricant, the raw material properties of filler excipients can have an impact on the disintegration behavior of a tablet. The current research aims to model the impact of lactose properties on…
Nanostructured Lipid Carriers for Oral Delivery of a Corticosteroid: Role of Formulation on…
Corticosteroids are potent anti-inflammatory and immunosuppressive drugs widely used world-wide for treatment of diverse conditions. However, their use is restricted by their poor bioavailability and high risk-benefit ratio. Therefore, the…
Lipid/Clay-Based Solid Dispersion Formulation for Improving the Oral Bioavailability of Curcumin
This study was conducted to develop a lipid/clay-based solid dispersion (LSD) formulation to enhance the dissolution and oral bioavailability of poorly soluble curcumin. Krill oil and aminoclay were used as a lipid and a stabilizer,…
AEROSIL® Pharma colloidal silicon dioxide – technical information
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and…
How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions:…
The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon®VA 64, Kolliphor®P 407, and…
MicroceLac® 100 – MEGGLE’s co-processed lactose grades for direct compression
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible…
Design, Formulation, and Characterization of Valsartan Nanoethosomes for Improving Their…
The objective of this study was to formulate and evaluate valsartan (VLT) ethosomes to prepare an optimized formula of VLT-entrapped ethosomes that could be incorporated into a sustained release transdermal gel dosage form. The formulation…
Histidine-Triggered GO Hybrid Hydrogels for Microfluidic 3D Printing
Graphene oxide (GO) hydrogels have provided tremendous opportunities in designing and fabricating complex constructs for diverse applications, while their 3D printing without photocuring is still a challenging task due to their low…
Emprove® by Merck: Quality you can count on – Addressing your requirements for parenteral…
Quality, purity, reliability.
Introducing our comprehensive product portfolio.
Sterile liquid applications demand excipients with the highest standards of quality, purity and reliability. To supply everything you need for your medicinal…
Sex-Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune,…
Males and females respond differently to medications due to physiologic, metabolic, and genetic factors. At times, sex-related differences cannot be mitigated by dose adjustment to body mass, and are evident from the tissue level to the…
What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity…
The discovery of carcinogenic nitrosamine impurities above the safe limits in pharmaceuticals has led to an urgent need to develop methods for extending structure–activity relationship (SAR) analyses from relatively limited datasets, while…
Development of a digital twin of a tablet that mimics a real solid dosage form: Differences in the…
The performance of colon-targeted solid dosage forms is commonly assessed using standardised pharmacopeial dissolution apparatuses like the USP II or the miniaturised replica, the mini-USP II. However, these fail to replicate the…
Effect of a superdisintegrant on disintegration of orally disintegrating tablets determined by…
Abstract
The disintegration time is critical for characterizing orally disintegrating tablets (ODTs), according to regulatory standards. The current study aimed to assess the effect of superdisintegrants such as sodium starch glycolate,…
CPHI 2022: Roquette Launches Next-Generation Direct Compression Solutions – PEARLITOL® CR-H Mannitol…
La Madeleine, France – October 31, 2022.
Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical and nutraceutical excipients, today announces the launch of two next-generation mannitol products for…
Oral Disintegrating Tablets – see the solution landscape
Introduction
Oral disintegrating tablets (ODTs) are patient-centric drug delivery systems (for example, for pediatrics, geriatrics, and psychiatric patients with dysphagia) designed to increase patient compliance. ODTs are preferred to…
Ashland injectable pharmaceutical excipient accepted into FDA Novel Excipient Review Pilot Program
WILMINGTON, Del., Oct. 31, 2022 -- Ashland Inc. (NYSE: ASH) today announced the United States Food and Drug Administration (FDA) Center for Drug Evaluation and Research Office of New Drugs has accepted Ashland Viatel™ bioresorbable…
Construction of Bio-conjugated nano-vesicles using non-ionic surfactants for targeted drug delivery:…
Introduction
Targeted delivery of drugs to the brain is a complicated activity. This complication is caused by the blood–brain barrier (BBB). Interestingly, there are various transporters on the surface of the BBB that are naturally used…
Microfluidic Particle Engineering of Hydrophobic Drug with Eudragit E100─Bridging the Amorphous and…
Co-processing active pharmaceutical ingredients (APIs) with excipients is a promising particle engineering technique to improve the API physical properties, which can lead to more robust downstream drug product manufacturing and improved…
Neusilin® the extraordinary excipient for solid dosage forms – Technical Newsletter
See the third issue of Fuji Chemical Industries Technical Newsletter. This issue focuses on achieving higher tablet hardness with pleasant mouth feel at good oral disintegranting (OD) times by addition of other common excipients.…
Thermal Inkjet Printing: Prospects and Applications in the Development of Medicine
Over the last 10 years, inkjet printing technologies have advanced significantly and found several applications in the pharmaceutical and biomedical sector. Thermal inkjet printing is one of the most widely used techniques due to its…
Novel drug delivery systems for the management of dry eye
Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted considerable research interest. Conventional therapy for DED involves the use of artificial tear products, cyclosporin, corticosteroids, mucin…
Preparation and characterization of cationic pullulan-based polymers with hydrophilic or amphiphilic…
Pullulan has attracted considerable attention due to its immunogenicity, biodegradability, biocompatibility, and hydrophilic nature, making it useful in cosmetics and pharmaceutical applications. In addition, pullulan is considered a…
Polymeric microneedles for enhanced drug delivery in cancer therapy
Microneedles (MNs) have attracted the interest of researchers. Polymeric MNs offer tremendous promise as drug delivery vehicles for bio-applications because of their high loading capacity, strong patient adherence, excellent…
A critical review of traditional and advanced characterisation tools to drive formulators towards…
The high degree of precision and control of 3D printing has given formulators the autonomy to engineer sophisticated and personalised medicines, starting a revolution in pharmaceutics. In addition, dosage forms with tailored drug release…
A concise treatise on model-based enhancements of cohesive powder properties via dry particle…
This paper presents a review of our key advances in model-guided dry coating-based enhancements of poor flow and packing of fine cohesive powders. The existing van der Waals force-based particle-contact models are reviewed to elucidate the…
Milled and Sieved Lactose – MEGGLE’s crystalline alpha-lactose monohydrate grades
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible…