Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Recent advancements in additive manufacturing techniques employed in the pharmaceutical industry: A…
Abstract
The 3–dimensional printing process (3DP) was patented in the 1980s, but the utilization of this process has expanded substantially over the past decade, to which the pharmaceutical industry is a major contributor. With increasing…
Phospholipid-Based Delivery Systems: Injectable Depot Formulations
Because many drugs have a short biological half-life, multiple administrations are needed to achieve a therapeutic effect. In addition, drugs may not be suitable for oral administration because of degradation in the gastrointestinal tract…
PharSQ® Spheres CM – Unique starter spheres for controlled drug release by Budenheim
Technical information:
PharSQ® Spheres CM by Budenheim is a unique co-processed material made of substances fully compliant with pharmacopoeial requirements:
80% w/w Anhydrous dibasic calcium phosphate (Ph.Eur.,USP/NF, JP)
20% w/w…
IFF to Highlight Industry-Leading Product Portfolio, Expertise at CPhI Frankfurt
NEW YORK — Oct. 26, 2022 —IFF's Pharma Solutions division—backed by 300 years of combined cellulosic excipient experience and housing leading brands like Avicel® and METHOCEL™, plus a robust seaweed-based excipient portfolio —will showcase…
A collaborative partner for powder processing R&D in universities and beyond – MEDELPHARM
Powder processing research and development (R&D) has its challenges, with experienced scientists and students alike coming across hurdles even when they have the best equipment. Rather than struggling alone, the key is collaboration.…
Analysis of phospholipids and triacylglycerols in intravenous lipid emulsions
Intravenous lipid emulsions (ILEs) are used for parenteral nutrition, providing a vital source of essential fatty acids and concentrated energy for patients who are unable to absorb nutrients via the digestive track. They are commonly used…
Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose
With the advent of continuous manufacturing, twin-screw melt granulation has attracted interest in the pharmaceutical industry as a method for co-processing excipients and developing new formulations. Twin-screw melt granulation relies on…
Physical stability of co-freeze-dried powders made from NaCl and maltodextrins – Impact of NaCl on…
NaCl is commonly added into food powders as a humectant or taste enhancer with little consideration of its impact on the physical properties and stability of powders. In this study, maltodextrins of dextrose equivalence (DE) 5, 20 and 45…
Patient-specific in vitro drug release testing coupled with in silico PBPK modeling to forecast the…
Biorelevant in vitro release models are valuable analytical tools for oral drug development but often tailored to gastrointestinal conditions in ‘average’ healthy adults. However, predicting in vivo performance in individual patients whose…
Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies,…
Abstract
Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress.…
Direct Compression of Probiotic Tablets with PROSOLV® EASYtab Nutra
Abstract
Although probiotics are mostly administered in the form of capsules, there are some advantages of tablets in terms of production effort, cost efficiency and stability of the probiotic bacteria. As probiotics are sensitive to high…
Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability,…
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature…
Industry Perspective on the Use and Characterization of Polysorbates for Biopharmaceutical Products…
Abstract
Polysorbate (PS) 20 and 80 are the main surfactants used to stabilize biopharmaceutical products. Industry practices on various aspects of PS based on a confidential survey and following discussions by 16 globally acting major…
A compactibility-based lubricant dispersion model describing the effect of formulation and paddle…
In rotary tablet presses, the powder flow into the dies is typically facilitated by paddle feeder. For internally lubricated formulations, the shear forces exerted by the paddle rotation can result in a considerable decrease in tablet…
Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium…
Drug delivery systems (DDS) for oral delivery of peptide drugs contain excipients that facilitate and enhance absorption. However, little knowledge exists on how DDS excipients such as permeation enhancers interact with the gastrointestinal…
Effect of binder type on physical and in vitro properties of high dose inosine acedoben dimepranol…
The present work was conducted with the aim to formulate and evaluate the immediate release of 1000 mg tablets containing Inosine Acedoben Dimepranol (IAD). All the samples of the tablets containing 1000 mg IAD were prepared by conventional…
Classification of scanning electron microscope images of pharmaceutical excipients using deep…
Convolutional Neural Networks (CNNs) are image analysis techniques that have been applied to image classification in various fields. In this study, we applied a CNN to classify scanning electron microscopy (SEM) images of pharmaceutical raw…
Preparation and evaluation of camptothecin analogues-loaded lyophilization using Kolliphor® HS 15 as…
FLQY2 is a camptothecin derivative modified by FL118 and proved to be good antitumor activity in vitro. However, its poor solubility leads to the low therapeutic efficacy in vivo. Here, the injectable FLQY2 lyophilized powder was prepared…
What does pKa mean?
See the new video from Pharma Drama. Prof. Simon Gaisford explains the concept of pKA:
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’ll explain the…
Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances…
In this study, poly (lactic-co-glycolic) acid (PLGA) particles were synthesized and coated with chitosan. Three essential oil (EO) components (eugenol, linalool, and geraniol) were entrapped inside these PLGA particles by using the…
Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions
Drug delivery using nanoparticles (NPs) represents a potential approach for therapy in cancer, such gastric cancer (GC) due to their targeting ability and controlled release properties. The use of advanced nanosystems that deliver…
Development of a new hydrogel for the prevention of allergic contact dermatitis
Allergic contact dermatitis (ACD) is the most prevalent occupational disease and the most common form of immunotoxicity in humans. Preventing exposure to the triggering allergens is the mainstay of treatment. However, avoidance is not…
Pazopanib-laden lipid based nanovesicular delivery with augmented oral bioavailability and…
The present investigation deals with the pazopanib-loaded solid lipid nanoparticles (Pazo-SLNs) and their in-vitro and in-vivo assessments. Quality by design approach employing the Plackett-Burman and central composite design was used to…
Combining drug salt formation with amorphous solid dispersions – a double edged sword
Glass transition temperature (Tg) is important for amorphous compounds because it can have implications on their physical and chemical stability. With drugs that possess ionizable acidic or basic groups, salt formation is a potential…
Development of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading of…
Purpose
The objective of this study was to incorporate a passive cyclic loading strategy into the infant air-jet dry powder inhaler (DPI) in a manner that provides high efficiency aerosol lung delivery and is insensitive to powder mass…
3D-Printed Microarray Patches for Transdermal Applications
The intradermal (ID) space has been actively explored as a means for drug delivery and diagnostics that is minimally invasive. Microneedles or microneedle patches or microarray patches (MAPs) are comprised of a series of micrometer-sized…
Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives
Abstract
Oral delivery is the preferred route of drug administration due to patient compliance and convenience. Despite this, nanomedicines have so far primarily been developed for the parenteral route. Inorganic nanoparticles hold great…
The clinical and translational prospects of microneedle devices, with a focus on insulin therapy for…
Abstract
Microneedles have the clinical advantage of being able to deliver complex drugs across the skin in a convenient and comfortable manner yet haven’t successfully transitioned to medical practice. Diabetes mellitus is a complicated…
Cellactose® 80 – MEGGLE’s co-processed lactose grades for direct compression
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible…
Fast and Curious Facts Series by Gattefossé – CPHI 2022
Gattefossé CPHI Francfurt 2022, booth 80C100
Knowing CPHI is a busy exhibition, and you don’t have much time, Gattefossé has created a new and interesting series:
Fast and Curious Facts,
short presentations aiming at giving essential…
Ibuprofen DC-100 for direct compression – See the chance for your process simplification
Pharmatrans SANAQ® offers Ibuprofen DC100 as an enhanced powdered active ingredient to assist simplified production of superior oral Ibuprofen formulations.
This improved physical form of Ibuprofen can be incorporated into designed…
An insight on lipid nanoparticles for therapeutic proteins delivery
Therapeutic proteins are well-tolerated bioactive compounds used in different therapies, due to its high specificity and biopotency. Nevertheless, they may also present some physicochemical instability, leading to loss of bioactivity…
Modeling gravity filling of dies on a rotary tablet press
For tableting on rotary presses, die filling is the quality dominating process step as the tablet weight and its variation is influenced. Therefore, a deeper understanding of this process is necessary. In this study, the filled powder…
Oral administration of zein-based nanoparticles reduces glycemia and improves glucose tolerance in…
The aim was to evaluate the effect of zein-based nanoparticles on the glucose homeostasis, following oral administration to Wistar rats. For this purpose, bare nanoparticles (NP, with tropism for the upper intestinal regions) and…