Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Influences of different microcrystalline cellulose (MCC) grades on tablet quality and compression…
Microcrystalline cellulose (MCC) is one of the most commonly used excipients in tablet formulations. At present, numerous grades of MCC are available for pharmaceutical manufacturing and significantly differ in particulate and powder…
Comparison of Various Fillers on the Physical Properties of Compounded Tablets
Abstract
Compounded tablets are solid dosage forms that contain active pharmaceutical ingredients that are usually formulated with suitable pharmaceutical excipients. Fillers are inert ingredients used as bulking agents that can affect the…
Tunable Drug Release from Fused Deposition Modelling (FDM) 3D-Printed Tablets Fabricated Using a…
Three-dimensional (3D) printing is proving to be a pivotal technology for developing personalized dosage forms with bench to bedside feasibility. Fused deposition modelling (FDM) 3D printing has emerged as the most used technique wherein…
Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery
Antipsychotic drugs have numerous disabling side effects, and many are lipophilic, making them hard to formulate at high strength. Incorporating them into nanometric emulsions can increase their solubility, protect them from degradation,…
Your visit at CPHI worldwide 2022 in Frankfurt
CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE…
Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated…
Purpose
Whilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in the paediatric population is often hindered by poor adherence. Currently, two long-acting (LA) intramuscular…
Integrating pressure sensor control into semi-solid extrusion 3D printing to optimize medicine…
Semi-solid extrusion (SSE) is a three-dimensional printing (3DP) process that involves the extrusion of a gel or paste-like material via a syringe-based printhead to create the desired object. In pharmaceuticals, SSE 3DP has already been…
What is a distribution coefficient?
An explanatory video by Prof. Simon Gaisford – Pharma Drama
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’m going to explain distribution coefficients – what…
New and Novel Excipients – Part 2
A week ago I wrote about the importance of new and novel excipients for the pharmaceutical industry and presented Klucel™ xtend and BioSustane™ in last week´s edition of "The Excipients Week".
In the meantime I launched a small poll with…
3D printing hybrid materials using fused deposition modelling for solid oral dosage forms
3D printing in the pharmaceutical and healthcare settings is expanding rapidly, such as the rapid prototyping of orthotics, dental retainers, drug-loaded implants, and pharmaceutical solid oral dosage forms. Through 3D printing, we have the…
Facile Fabrication of Dual Functional Graphene Oxide Microcapsules Carrying Corrosion Inhibitor and…
Dual functional graphene oxide (GO) microcapsules were fabricated through self-assembly in Pickering emulsions, carrying corrosion inhibitor benzotriazole (BTA) on the microcapsule shells and encapsulating a self-healing agent epoxy…
Intrinsic lipolysis rate for systematic design of lipid-based formulations
Lipid-based formulations (LBFs) are used by the pharmaceutical industry in oral delivery systems for both poorly water-soluble drugs and biologics. Digestibility is key for the performance of LBFs and in vitro lipolysis is commonly used to…
Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate
The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME). A fast…
Influence of de-structured starch on fine-stranded polymeric and coarse-stranded particulate whey…
This study investigated the phase stability of liquid mixtures and composite gels properties of de-structured waxy potato starch (DWPS) and whey protein isolate (WPI). The DWPS are physically-modified starches treated at 120, 140 and 150 °C…
Formulation and characterization of orodispersible tablet of glimepiride
Abstract
The present study is regarding, Glimepiride is one derivatives of sulfonyl urea used in the treatment of Type II DM which classified as class-II (BCS) of high permeability and low degree of solubility. The endeavor is to improve…
The Stability of Probiotics in Pharmaceutical Products
Abstract
Due to their large potential applications in human diseases such as gastrointestinal disorders, immunomodulation or cholesterol reduction, probiotic products are of great interest to the pharmaceutical industry. The formulation…
Emulfree® Duo: Finalist at CPHI Award 2022!
Gattefossé Pharmaceuticals´new product Emulfree® Duo has been shortlisted in the category "Finished Formulations", at CPHI Awards 2022.
Of course, Gattefossé wants to thank all the people at Gattefossé who contributed to this success and…
CombiLac® – MEGGLE’s co-processed lactose grades for direct compression
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible…
Design and development of 3D-printed Bento Box model for controlled drug release of propranolol HCl…
The goal of this study was to develop a 3D-printed bento box model (3D-printed BB) with one or two chambers containing propranolol hydrochloride (PNL) as powder and matrix tablet for controlled drug release at varying times using United…
A weight of evidence review of the genotoxicity of titanium dioxide (TiO₂)
Titanium dioxide is a ubiquitous white material found in a diverse range of products from foods to sunscreens, as a pigment and thickener, amongst other uses. Titanium dioxide has been considered no longer safe for use in foods (nano and…
Effect of fill level in continuous twin-screw granulator: A combined experimental and simulation…
Twin-screw granulators for continuous wet granulation have attracted interest in the pharmaceutical industry. The physical properties of granules and tablets prepared through the twin granulation process depend on several factors, such as…
Existing and emerging mitigation strategies for the prevention of accidental overdose from oral…
Misadventure with pharmaceutical oral medication has been on the rise, with the opioid crisis playing a major part. Drug overdose related to opioids has become such an issue, that it has been labelled a worldwide crisis. This review…
An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to COVID-19 and has become a pandemic worldwide with mortality of millions. Nanotechnology can be used to deliver antiviral medicines or other types of viral…
Lipid nanocapsules enhance the transdermal delivery of drugs regardless of their physico-chemical…
The transdermal application of actives offers numerous advantages over other conventional routes. Namely, a stable level of drugs in the bloodstream and reduced side effects are the argument for topical administration. Unfortunately, the…
Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for…
The relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and…
Drug Discovery, Development and Deployment Maps
The Drug Discovery, Development and Deployment Maps (4DM) provide dynamic representations of the modern therapeutic development process to more easily identify inefficiencies and integrate efforts to expedite new therapies for patients. The…
RXCIPIENTS® FM 1000 – A versatile excipient for orally disintegrating tablet (ODT)…
1. Introduction
Certain patient groups, specifically elderly and infant
patients, experience difficulties with swallowing oral
dosages of medication. Orally disintegrating tablets (ODTs) are one approach to ease the intake, helping…
Design and Development of Dual Functional Colon Targeted Eudragit/Chitosan Nanoparticles: A QbD…
Aim: The goal of this study was to develop colon-targeted nanoparticulate systems of the anti-inflammatory agent Quercetin (QU) and evaluate the formulation for various parameters that would allow the active ingredient to be released at a…
What is ideal solubility?
An explanatory video by Prof. Simon Gaisford – Pharma Drama
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’m going to explain the concept of ideal solubility –…
Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes
Currently, the only practical way to treat type 1 and advanced insulin-dependent type 2 diabetes mellitus (T1/2DM) is the frequent subcutaneous injection of insulin, which is significantly different physiologically from endogenous insulin…
Pharma 4.0-Artificially Intelligent Digital Twins for Solidified Nanosuspensions
Digital twins capacitate the industry 4.0 paradigm by predicting and optimizing the performance of physical assets of interest, mirroring a realistic in-silico representation of their functional behaviour. Although advanced digital twins…
What is dissolution?
An explanatory video by Prof. Simon Gaisford – Pharma Drama
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I’m going to explain the concept of dissolution – the…
Hayashibara Maltose PH – Injectable Grade brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Maltose PH
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and…
Ashland announces Klucel™ xtend HPC matrix former for extended-release tablets
Wilmington, Del., Oct. 3, 2022
Ashland is introducing Klucel™ xtend hydroxypropyl cellulose (HPC) controlled release matrix former, designed to deliver unsurpassed process versatility and release profile efficiency. It is the latest…