Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
New and Novel Excipients
The pharmaceutical industry needs innovative, new and novel excipients solutions to support the developments in next generation therapeutics, new manufacturing concepts (eg. continuous manufacturing, 3Dprinting, etc.), drug delivery and API…
When coating runs smoothly – Parteck® COAT: Reduce your process time with an optimized polymer…
Our broad range of formulation products covers excipients for solid, semi-solid and liquid dosage forms for small and large molecules. Additionally, we offer a portfolio of drug delivery compounds (DDCs), as well as solutions for solubility…
Intra-vaginal Gemcitabine-Hybrid Nanoparticles for effective cervical cancer treatment
Aim
This study aims to develop and evaluate hybrid nanoparticles for the effective intravaginal delivery of the anticancer gemcitabine in cervical cancer rat model.
Methodology
Gemcitabine loaded hybrid nanoparticles (GEM-HNPs)…
Hydroxypropyl-β-cyclodextrin/Oridonin and Trehalose loaded nanovesicles attenuate foam cells…
Hydroxypropyl-β-Cyclodextrin (HP-β-CD) was used to form the HP-β-CD/Oridonin inclusion complex. Then, the novel Multi-loaded nanovesicles systems (NVs) were established to encapsulate both hydrophilic (Trehalose) and hydrophobic drugs…
Engineering the right formulation for enhanced drug delivery
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules and biologics and offer several advantages for inhaled therapy. Early DPI products were intended to treat asthma and lung chronic inflammatory disease…
Considerations in the developability of peptides for oral administration when formulated together…
This paper reviews many of the properties of a peptide that need to be considered prior to development as an oral dosage form when co-formulated with a permeation enhancer to improve oral bioavailability, including the importance and…
An evaluation of film coating materials and their predicted oro-esophageal gliding performance for…
Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system until reaching the stomach. Previous studies have provided evidence that…
SANAQ® SL 004 – Starch & Lactose
PHARMATRANS SANAQ offers excipients and active ingredients of outstanding quality and performance. With our research & development skill and tradition, we commit to study innovative technological solutions providing excipients…
Evaluation of Newly Designed and Traditional Punches in Manufacturing of Scored ODTs
To overcome difficulties in splitting, uneven breaking and inconsistent dosing frequently reported with scored tablets, a novel punch was proposed for the manufacturing of easy breakable tablets (EBTs). In this work, the performance of the…
Investigation of granular dynamics in a continuous blender using the GPU-enhanced discrete element…
Continuous powder blending is an essential operation during continuous pharmaceutical manufacturing. However, the complex granular dynamics in the blender is still poorly understood. This study employs a graphic processor unit (GPU)…
Self-regulated Anti-Overdose Crush and Extraction-Resistant Drug Delivery System to Combat Opioid…
Pharmaceutical opioid dosage forms are commonly misused via an oral route in non-manipulated form, i.e., overdose in intact form, or manipulated form, i.e., after crushing the dosage form, and also via the non-oral route in manipulated…
Tablets Made from Paper—An Industrially Feasible Approach
Many orally administrated drugs exhibit poor bioavailability due to their limited solubility. The smartFilm technology is an innovative approach to improve the drug aqueous solubility, where the drug is embedded within the matrix of…
Development of a multiparticulate drug delivery system for in situ amorphisation
In the current study, the concept of multiparticulate drug delivery systems (MDDS) was applied to tablets intended for the amorphisation of supersaturated granular ASDs in situ, i.e. amorphisation by microwave irradiation within the final…
Design and development of orally disintegrating films: A platform based on hydroxypropyl…
From a design of experiments (DOE) performed under four independent variables, with the filmogenicity conditions and shortest disintegration time as the answers, a new oral disintegrating film (ODF) based on hydroxypropyl methylcellulose…
Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug…
Increased life expectancy has led to a rise in age-related disorders including neurological diseases such as Alzheimer’s disease and Parkinson’s disease. Limited progress has been made in the development of clinically translatable therapies…
Hayashibara Trehalose 100 PH – brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and creative…
Continuous Processing of Micropellets via Hot-Melt Extrusion
Microparticulate drug delivery systems, e.g., micropellets (MPs), are used in a variety of pharmaceutical formulations such as suspensions, injectable systems, and capsules. MPs are currently manufactured mainly via batch, solvent-based…
Maillard reaction between pea protein isolate and maltodextrin via wet-heating route for emulsion…
Pea protein isolate (PPI)-maltodextrin (MD) conjugates were prepared by using controlled Maillard reaction at 90 °C in the solution state (wet-heating route). The degree of conjugation between PPI and MD was measured in terms of evolved…
Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine
Infected chronic skin wounds and other skin infections are increasingly putting pressure on the health care providers and patients. The pressure is especially concerning due to the rise of antimicrobial resistance and biofilm-producing…
Pioneering Taste Acceptability For All
Taste acceptability is an important factor in the development of a drug product, especially when it comes to paediatric dosage forms.
Gustoceutics provides a biosensor taste testing service to improve acceptability and compliance of…
Orodispersible Film (ODF) Platform Based on Maltodextrin for Therapeutical Applications
Orodispersible film (ODF) is a new dosage form that disperses rapidly in the mouth without water or swallowing. The main ingredient of an ODF is a polymer that can be both of natural or synthetic origin. Maltodextrin is a natural polymer,…
Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through…
The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). A preliminary procedure of vehicles obtained just…
Detrimental Effect of the Film Coat Chemistry and Thickness on the Physical Stability of Amorphous…
Amorphous solid dispersions (ASDs) have been widely utilized to enhance the bioavailability of pharmaceutical drugs with poor aqueous solubility. The role of various excipients on the amorphous drug to crystalline form conversion in ASDs…
Quality by Design of Pranoprofen Loaded Nanostructured Lipid Carriers and Their Ex Vivo Evaluation…
Transmucosal delivery is commonly used to prevent or treat local diseases. Pranoprofen is an anti-inflammatory drug prescribed in postoperative cataract surgery, intraocular lens implantation, chorioretinopathy, uveitis, age-related macular…
Molecular Basis of Sweetness, Recent Concepts, an Ideal Sweetener and Saccharide and Non-saccharide…
Understanding of the sweetness of an organic or inorganic substance is complex process and it is ingrained with the intricacies of psychological perception, molecular structure, chemical nature and environmental conditions e.g. pH,…
Tunable Polymeric Mixed Micellar Nanoassemblies of Lutrol F127/Gelucire 44/14 for Oral Delivery of…
Hymenolepiasis represents a parasitic infection of common prevalence in pediatrics with intimidating impacts, particularly amongst immunocompromised patients. The present work aimed to snowball the curative outcomes of the current mainstay…
Overcoming skin barriers through advanced transdermal drug delivery approaches
Upon exhaustive research, the transdermal drug delivery system (TDDS) has appeared as a potential, well-accepted, and popular approach to a novel drug delivery system. Ease of administration, easy handling, minimum systemic exposure, least…
DiCom SANAQ® SP205 / SP206 – Co-processed excipient for direct compression of hygroscopie and…
PHARMATRANS SANAQ offers excipients and active ingredients of outstanding quality and performance. With our research & development skill and tradition, we commit to study innovative technological solutions providing excipients…
In Vivo Evaluation of a Gastro-Resistant HPMC-Based “Next Generation Enteric” Capsule
Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the…
Development of a Novel Lipid-Based Nanosystem Functionalized with WGA for Enhanced Intracellular…
Despite a considerable number of new antibiotics under going clinical trials, treatment of intracellular pathogens still represents a major pharmaceutical challenge. The use of lipid nanocarriers provides several advantages such as…
Fabrication and Characterizations of Pharmaceutical Emulgel Co-Loaded with Naproxen-Eugenol for…
The aim of this study was to fabricate and characterize a pharmaceutical emulgel co-loaded with naproxen/eugenol for transdermal delivery to improve the analgesic and anti-inflammatory effects and to eliminate GIT adverse reactions. Emulgel…
Microencapsulation of curcumin by ionotropic gelation with surfactants: Characterization, release…
The purpose of this work was to encapsulate curcumin in pectin beads by ionotropic gelation method in order to improve its solubility and its bioavailability and to preserve its antioxidant activity in the presence of surfactants…
Pharmaceutical Technical Newsletter F-Melt® by Fuji Chemical Industries
See the second issue of Fuji Chemical Industries Technical Newsletter. This issue focuses on achieving higher tablet hardness with pleasant mouth feel at good oral disintegranting (OD) times by addition of other common excipients.…
Exploration of Parteck® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor…
To manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic…