Experimental Investigation on Efficacy of Eudragit RS 100 Polymer in Prolonging Glibenclamide Release by Intragastric Floating Microsphere Formulation and Physicochemical Evaluation
Abstract
Background: The amalgamation of targeted transportation and enhancement of the release profile of the active pharmaceutical ingredient is a contemporary trend in the evolution of oral medicinal products. A renowned method to actualize this concept is to develop floating gastroretentive delivery systems that ensure an extended stay of the…
Expert interview with Marc Müller (Head of Business Development BIOGRUND GmbH) about CompactCel®…
What were the reasons for developing a new disintegrant premix based on natural ingredients?
For years, we have seen an increased interest in a healthy lifestyle on the consumer side. Not only in the USA, but also in Europe, consumers…
Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection
Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?
Introduction: Cystic fibrosis (CF) is associated with pulmonary Pseudomonas aeruginosa infections persistent to antibiotics.
Methods: To eradicate pseudomonal biofilms,…
Formulation Development, Characterization, and Evaluation of Bedaquiline Fumarate -Soluplus® -Solid…
Bedaquiline fumarate (BQF) is classified as a BCS class II drug and has poor water solubility and dissolution rate, which ultimately compromises bioavailability. The objective of this study is to improve the biopharmaceutical properties of…
STYL’One Evo R&D – Scale-Up and Production Support
STYL’ONE EVO TABLETING INSTRUMENT
The all-in-one multi-functional R&D press from early API characterization and formulation to scale-up at production speed
The most advanced R&D press designed as multifunction tool adapted to…
Mitigating Particle Formation During Ultrafiltration/Diafiltration of Biologics with KLEPTOSE® HPβCD…
INTRODUCTION
Ultrafiltration/diafiltration (UF/DF) is an integral part of every biotherapeutic downstream process. A typical UF/DF process requires several passes through the pump and the membrane cassette, often taking several hours for…
Effect of drug load on the aerosolisation propensity of binary adhesive mixtures for inhalation
Abstract
The aim of this study was to investigate how the propensity for aerosolisation in binary adhesive mixtures was affected by the drug load, and to determine whether these findings could be linked to different blend states. Binary…
A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric…
Abstract
TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability, nanometric size and tissue penetration ability.…
Formulation development of nanostructured lipid carrier-based nanogels encapsulating tacrolimus for…
The goal of this study was to formulate tacrolimus nanogel based on nanostructured lipid carrier (NLC) in order to improve the efficacy, aesthetic, and patient compliance for the treatment of psoriasis. The microemulsion method was used to…
Is it advantageous to use quality by design (QbD) to develop nanoparticle-based dosage forms for…
Abstract
Parenteral administration is one of the most commonly used drug delivery routes for nanoparticle-based dosage forms, such as lipid-based and polymeric nanoparticles. For the treatment of various diseases, parenteral…
Lipid-based nanoparticles as a promising treatment for the skin cancer
Abstract
The prevalence of skin disorders, especially cancer, is increasing worldwide. Several factors are involved in causing skin cancer, but ultraviolet (UV) light, including sunlight and tanning beds, are considered the leading…
Kollidon® 90 Evo – A highly effective water soluble binder with low impurity profile
Join the evolution of the BASF PVP portfolio! Kollidon® 90 Evo combines outstanding purity and innovative packaging.
Kollidon® 90 Evo is a highly effective binder with exceptional purity
Very low impurity profile, e.g.,…
Improved Transdermal Delivery of Novel Cannabinoid-Loaded Patches Using Eudragit Matrix
The main active cannabinoids in extracts of Cannabis sativa L., cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA), are known for their pharmacological effects, including anti-inflammatory, analgesic, psychedelic, anti-cancer,…
Application of Liquisolid Pellets Technology for Improving Dissolution of Posaconazole: A DoE Based…
Abstract
Purpose
Posaconazole (PSZ) is BCS class-II drug that displays variable bioavailability upon oral administration due to extremely low and pH-dependent solubility.
Method
The present investigation was aimed to formulate and…
Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent…
Abstract
The global community is faced with numerous health concerns such as cancer, cardiovascular and neurological diseases, diabetes, joint pain, osteoporosis, among others. With the advancement of research in the fields of materials…
Pediatric Drug Delivery Challenges: Enhancing Compliance Through Age-appropriate Formulations and…
Abstract
Pediatric pharmacotherapy presents distinctive challenges compared with adult pharmacotherapy and encompasses considerations such as drug administration methods, susceptibility to medication-related toxicity, and taste…
Evaluation of Printability of PVA-Based Tablets from Powder and Assessment of Critical Rheological…
Abstract
Fused deposition modeling (FDM) is a rather new technology in the production of personalized dosage forms. The melting and printing of polymer–active pharmaceutical ingredient (API)—mixtures can be used to produce oral dosage…
STYL’One Nano R&D compaction simulator for early-stage material characterization and…
The MEDELPHARM STYL’One Nano is a compact yet powerful compaction simulator designed for early-stage tablet formulation in research and development settings. It provides researchers with a comprehensive solution for addressing formulation…
PHARMACOAT® – Easy to use film coating material that provides an excellent finish
Shin-Etsu Chemical supplies the various excipients for pharmaceutical industry and developed PHARMACOAT® in the 1960s during the early days of film coating and since then it has been the subject of a continuous development and quality…
New services offered by PMC Isochem
PRESS RELEASE
PMC Isochem is extending its R&D capabilities offering additional services for analytical development, formulation and bioengineering to external companies and customers!
Analytical Development:
Discover PMC…
Exploring the Potential of Polymeric Excipients for Nasal Formulations
In recent years, the landscape of pharmaceutical formulations has been witnessing a significant shift towards non-invasive delivery methods. Among these, nasal administration has emerged as a promising option, particularly in the wake…
Modification of microenvironmental pH of nanoparticles for enhanced solubility and oral…
This study aimed to develop a novel pH-modified nanoparticle with improved solubility and oral bioavailability of poorly water-soluble celecoxib by modifying the microenvironmental pH. After assessing the impact of hydrophilic polymers,…
Elucidation of processing parameters for the reverse engineering of tablets
Abstract
Reverse engineering can assist in decoding the formula and manufacturing parameters employed in innovator formulations. Generic pharmaceutical industries use it to develop generic cheaper versions of innovator tablets. Herein, we…
Impact of two-step glidant mixing process on flow performance of coated curcumin – in vitro,…
Curcumin is a well-known phenolic compound obtained from Curcuma Longa L. It is used popularly as an antioxidant, anti-inflammatory, antispasmodic, antithrombotic, anticancer as well as immune-modulator. In the last couple of years, few…
QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy…
To formulate and optimize Ozenoxacin nano-emulsion using Quality by Design (QbD) concept by means of Box–Behnken Design (BBD) and converting it to a gel to form Ozenoxacin nano-emulgel followed by physico-chemical, in-vitro, ex-vivo and …
New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline…
Abstract
Nanocrystalline cellulose (CNC) has emerged as a subject of researcher’s interest because of its diverse attributes encompassing biocompatibility, sustainability, a high aspect ratio, and an abundance of −OH groups suitable for…
Dissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS)…
Abstract
Self-nanoemulsifying drug delivery systems (SNEDDS) have been used to improve the oral bioavailability of various drugs. In the current study, apigenin was developed as SNEDDS to solve its dissolution problem and enhance oral…
A drug repurposing approach of Atorvastatin calcium for its antiproliferative activity for effective…
Breast cancer, the most common cancer among women, caused over 500,000 deaths in 2020. Conventional treatments are expensive and have severe side effects. Drug repurposing is a novel approach aiming to reposition clinically approved…
Investigating the impact of air distribution on spray dryer operability using CFD simulations and…
Fouling reduces spray dryer operability. The impact of different configurations of a spray dryer on operability and nozzle-zone agglomeration stimulated by dry powder dosing was investigated through a combination of CFD simulations and…
Vitafoods Geneva 2024 – with a focus on excipients
This year Vitafoods Europe opens its doors for the last time in Geneva at Palexpo.
From 14th to 16th May you can have a face-to-face chat with visitors and exhibitors again.
Pharma Excipients gives you an overview of the excipient…
Taste-Masked Pellets of Warfarin Sodium: Formulation towards the Dose Personalisation
Abstract
The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose…
Enhanced mechanical and antimicrobial properties of hydroxypropyl methylcellulose films…
In this study, we produced hydroxypropyl methylcellulose (HPMC) films containing silver nanoparticles (AgNPs) by a straightforward method for potential wound dressing applications. Polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA) was…
Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles:…
Abstract
Aim: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release.
Materials/methods: OLZ SLNs were prepared by hot melt…
Shin-Etsu AQOAT® – Enteric coating polymer and solid dispersion carrier
Shin-Etsu supplies the various excipients for pharmaceutical industry. Let us introduce you Shin-Etsu AQOAT® Hypromellose acetate succinate (HPMCAS, NF, JP), an enteric coating material that can be used in aqueous or organic media.…
Closer to the Formulator (C2F) – A Center of Excellence by DFE Pharma
DFE Pharma is a global leader in pharma and nutraceutical excipient solutions. They develop, produce and supply high quality functional excipients for use in the pharmaceutical, biopharmaceutical, and nutraceutical industries for…