Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Poloxamer: a simple and powerful solution for accelerating dissolution
Oral administration is the most commonly employed route for drug delivery. It is cost-effective and convenient for the patient, leading to high patient compliance. In order for the API to exert a physiological effect it must pass from the…
Research of the selection of a gelling agent with further saturation of wipes with active prolonged…
Introduction
During our research of the selection of gelling agents followed by saturation of wipes with an active prolonged effect, many factors should be considered. This fact may influence further drug development. The most important…
Mathematical modeling of coating time in dry particulate coating using mild vibration field with…
To theoretically understand the previously reported dry particulate coating process using a mild vibration field with a bead media, a mathematical analysis model of the dry coating system was developed. In this coating process, an ordered…
Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug…
Objectives: To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying drug delivery system (SNEDDS).
Methods: Initially, the solubility of the EZE was determined in…
In-situ tear fluid dissolving nanofibers enable prolonged viscosity-enhanced dual drug delivery to…
Liquid and semi-solid formulations are the most commonly used drug delivery systems for ophthalmic diseases. Upon application into the conjunctival sac, these systems introduce a variable and unphysiologically high liquid volume to the eye,…
Design and evaluation of glimepiride hydrogel for transdermal delivery
The solubility of glimepiride (GM) was improved from 1.6 μg/mL to 22.0 mg/mL when GM and meglumine (MU) complexes were prepared. Therefore, transdermal hydrogels of GM Carbopol (GM-CP) and GM hydroxypropyl methylcellulose pullulan…
Design of Liposomal Lidocaine/Cannabidiol Fixed Combinations for Local Neuropathic Pain Treatment
The administration of drug fixed combinations by nanocarriers is a new attractive approach since it can allow improvements in both the skin penetration of cargo compounds and their synergistic effects. The cutaneous administration of…
Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid…
The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery…
Solid lipid nanoparticles and nanostructured lipid carriers of dual functionality at emulsion…
Solid lipid nanoparticles and nanostructured lipid carriers are two types of lipid nanoparticulate systems, that have been primarily studied for their capability to function as active carriers, and only more recently utilised in Pickering…
Formulation and Evaluation of the In Vitro Performance of Topical Dermatological Products Containing…
The selection of an appropriate vehicle in a semi-solid topical product is of utmost importance since the vehicle composition and microstructure can potentially cause changes in drug–vehicle or vehicle–skin interactions and affect drug…
Solubility Enhancement of Ebastine by Formulating Microemulsion Using D-Optimal Mixture Design:…
Ebastine, a histamine H1 antagonist, nonsedating, belonging to BCS class II is used in the treatment of allergic rhinitis and chronic idiopathic urticaria. The current study was intended in augmenting the aqueous solubility and dissolution…
RetaLac® – MEGGLE’s co-processed hypromellose lactose excipient for direct compression
RetaLac® by MEGGLE is a co-processed excipient comprising of equal parts of milled alpha-lactose monohydrate and hypromellose (USP substitution type 2208) with a nominal viscosity of 4000 cps. A specialized spray-agglomeration process…
Elucidation of lactose fine size and drug shape on rheological properties and aerodynamic behavior…
Pulmonary drug delivery has gained great attention in local or systemic diseases therapy, however it is still difficult to scale-up DPI production due to the complexity of interactions taking place in DPI systems and limited understanding…
Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle…
Micronized particles are commonly used to improve the content uniformity (CU), dissolution performance, and bioavailability of active pharmaceutical ingredients (API). Different particle engineering routes have been developed to prepare…
Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in…
Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling…
Hayashibara Trehalose SG – Heat Stability brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and creative…
Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering
Chronic wounds (resulting from underlying disease, metabolic disorders, infections, trauma, and even tumours) pose significant health problems. In this work, microparticles, based on polysaccharides (maltodextrin or dextran) and amino…
Development of a safe pediatric liquisolid self-nanoemulsifying system of triclabendazole for the…
Fascioliasis, a common parasitic infection observed in the pediatric patient population, is a leading cause of concern in countries with poor/unhealthy water resources. To treat this condition first line agent such as triclabendazole (TBZ)…
Spray-freeze-dried lyospheres: Solid content and the impact on flowability and mechanical stability
Handling low-density pharmaceutical products, such as lyophilises, presents a challenge. Spray-freeze-dried (SFD) particles, overcoming many of these challenges, were analysed regarding flowability, mechanical stability, product properties…
The use of natural gums to produce nano-based hydrogels and films for topical application
Natural gums are a source of biopolymeric materials with a wide range of applications for multiple purposes. These polysaccharides are extensively explored due to their low toxicity, gelling and thickening properties, and bioadhesive…
Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to…
Orodispersible minitablets (ODMTs) offer several benefits like easy swallowability, dose flexibility and simple manufacturing through direct compression. In this study, the effect of lubrication on five different co-processed excipients…
Andrographolide liquisolid using porous-starch as the adsorbent with enhanced oral bioavailability…
Andrographolide (AGL) is the major component of Andrographispaniculata. The poor water solubility and low dissolution strongly affect its oral absorption. Liquisolid technology has been used to improve its dissolution and oral…
Anhydrous Lactose Family by Kerry
Excipients for direct tabletting and granulation
Product Description
Lactose Overview
Lactose is a disaccharide of glucose and galactose obtained from the whey fraction of bovine milk. Depending on the temperatures used to…
Advanced Formulations/Drug Delivery Systems for Subcutaneous Delivery of Protein-Based…
Multiple advanced formulations and drug delivery systems (DDSs) have been developed to deliver protein-based biotherapeutics via the subcutaneous (SC) route. These formulations/DDSs include high-concentration solution, co-formulation of two…
Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug…
The lipophilicity of a peptide drug can be considerably increased by hydrophobic ion pairing with amphiphilic counterions for successful incorporation into lipid-based formulations. Herein, to enhance the oral absorption of insulin (INS), a…
Amorphous Solid Dispersions (ASDs): The Influence of Material Properties, Manufacturing Processes…
Abstract
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral absorption leading to poor bioavailability. Several approaches exist that improve the oral absorption of such compounds by enhancing…
Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols
Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration, chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would hugely benefit from specific and potent peptide…
EFSA, Bias, and Titanium Dioxide
EFSA cites a paper that lacks a vehicle control in addition to several papers with flawed study designs and inappropriate statistical analyses. All of this increases the risk of bias in EFSA's Opinion on E171 (Titanium Dioxide).
by Lyle…
Recent developments in lactose blend formulations for carrier-based dry powder inhalation
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of…
The Effect of Cellulose Nanofibers on the Manufacturing of Mini-Tablets by Direct Powder Compression
Mini-tablets (MTs) contain a small amount of active pharmaceutical ingredients in one small tablet. MTs are advantageous because they can be fine-tuned according to the age and weight of pediatric patients and they are easy for children and…
Coating of primary powder particles improves the quality of binder jetting 3D printed oral solid…
Binder jetting (BJ) 3D printing is especially suitable for fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes. However, one of the…
DuraLac® H – MEGGLE’s anhydrous lactose grade for direct compression
General information
Direct compression (DC) tablet manufacture is a popular choice because it provides the least complex, most cost effective process to produce tablets compared to other tablet manufacturing approaches. Manufacturers can…
A mucoadhesive patch loaded with freeze-dried liposomes for the local treatment of oral tumors
Oral cancers affect millions of people globally, with increasing incidences among adults aged 35 and above. Poor drug uptake by lesions in the oral cavity following systemic administration, as well as limited localized treatment modalities…
Nagase Viita (formerly Hayashibara) Trehalose SG – Injectable Grade
Nagase Viita (formerly Hayashibara) ― A world leading supplier of pharmaceutical grade Trehalose
Founded as a starch syrup manufacturer in 1883, Nagase Viita (formerly Hayashibara) has grown into a company with strong research and…