Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Efficient Delivery of DNA Using Lipid Nanoparticles
DNA vaccination has been extensively studied as a promising strategy for tumor treatment. Despite the efforts, the therapeutic efficacy of DNA vaccines has been limited by their intrinsic poor cellular internalization. Electroporation,…
Formulating Drug Products for Optimized Absorption: Elucidating Amorphous Solid Dispersions
CDER scientists are seeking ways to improve the bioavailability of drugs that on their own do not dissolve well in water. Recent CDER research explores the potential for using amorphous solid dispersions to formulate generic drug products…
LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen…
The in vivo half-life is a key property of every drug molecule, as it determines dosing regimens, peak-to-trough ratios and often dose. However, half-life optimization can be challenging due to its multifactorial nature, with in vitro…
On the Utility of Chemical Strategies to Improve Peptide Gut Stability
Abstract
Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a key bottleneck in oral peptide drug development. Here, we present a systematic analysis of (i) the gut stability of disulfide-rich…
In vitro profiling of fenofibrate solid dispersion mediated tablet formulation to treat high blood…
Objective:
Fenofibrate (FNF), an anti-hyperlipidemic agent, suffers from poor water solubility (0.000707 mg/ml) and belongs to class II drug as per BCS, shows a slow dissolution rate. The current investigation aimed to fabricate a…
PMC Isochem – Your partner for Smart & Innovative Solutions
See in the following a part of the company brochure by PMC Isochem
PMC Isochem offers Drug Delivery solutions, CDMO services and Active Pharmaceutical Ingredients and intermediates:
From development to GMP production of…
On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles
The administration of drugs to the central nervous system (CNS) is primarily controlled by the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds from the blood to the brain's extracellular fluid. Although…
Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on…
Amphotericin B is an effective polyene antifungal considered as a “gold standard” in the management of fungal infections. Currently, it is administered mainly by IV due to poor aqueous solubility, which precludes its delivery orally.…
Preparation of melatonin novel-mucoadhesive nanoemulsion used in the treatment of depression
In this current research work has a main aim to develop a novel Melatonin (MLT: BCS class II drug)-loaded nanoemulsion for the improvement in solubility. A developed novel-NE was to evaluate and compare the efficacy of Melatonin-loaded…
Fused deposition modeling 3D printing of solid oral dosage forms containing amorphous solid…
Many active principles belong to the second class of the Biopharmaceutics Classification System due to their low aqueous solubility. Elaboration of new solid oral forms by hot-melt extrusion and fused deposition modeling appears as a…
Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and…
Insulin nanoparticles (NPs) with high loading content have found diverse applications in different dosage forms. This work aimed to evaluate the impact of freeze-drying and spray drying process on the structures of insulin-loaded…
Design of Experiments as a Tool to Optimize the Process of Coating Minitablets with Commercial…
According to the Quality by Design (QbD) concept, Design of Experiment (DoE) was used to indicate critical process parameters and optimize the fluid bed coating of minitablets in a laboratory size batch. Full factorial design was employed…
Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient…
Selecting the appropriate formulation and solubility-enabling technology for poorly water soluble drugs is an essential element in the development of formulations for paediatric patients. Different methodologies and structured strategies…
Lactose Spray Dried Monohydrate by Kerry
Excipients for direct tabletting, granulation, capsules, sachet filling and inhalation
Product Description
Lactose Overview
Lactose is a disaccharide of glucose and galactose obtained from the whey fraction of bovine milk.…
What is pH?
An explanatory video by Prof. Simon Gaisford – Pharma Drama
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this short video I’ll explain the concept of pH – and I should say…
Influence of Mechanical Skin Treatments on Dermal Penetration Efficacy of Active Ingredients
The effective dermal penetration of active ingredients (AI) is a major task in the formulation of topical products. Besides the vehicle, the mechanical skin treatments are also considered to impact the penetration efficacy of AI. In…
Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic…
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this…
PLA-PCL Microsphere Formulation to Deter Abuse of Prescription Opioids by Smoking
Opioids are commonly prescribed across the US for pain relief, despite their highly addictive nature that often leads to abuse and overdose deaths. Abuse deterrent formulations (ADFs) for prescription opioids make the non-therapeutic use of…
In Vitro Release, Mucosal Permeation and Deposition of Cannabidiol from Liquisolid Systems: The…
This work investigated the influence of liquid vehicles on the release, mucosal permeation and deposition of cannabidiol (CBD) from liquisolid systems. Various vehicles, including EtOH, nonvolatile low- and semi-polar solvents, and liquid…
Sequential fixed-fluidized bed foam granulation (SFFBFG) and drying: Multivariate model development…
Foam granulation (FG) is a non-conventional technique in which a binding solution is sprayed as aqueous foam. The main objectives of this work are, converting a lab-scale fluidized bed dryer into a fluidized bed foam granulator and dryer.…
The influence on the oral bioavailability of solubilized and suspended drug in a lipid nanoparticle…
The present study investigated the oral bioavailability of celecoxib when incorporated into solid lipid nanoparticles either dissolved or suspended. In vitro drug release in different media, in vivo performance, and in vitro-in vivo …
Structured approach for designing drug-loaded solid products by binder jetting 3D printing
Additive manufacturing allows for designing innovative properties to pharmaceutical products. Binder jetting (BJ) 3D printing is one of the key techniques within innovative manufacturing. In this study, a structured approach according to…
What is a base?
An explanatory video by Prof. Simon Gaisford – Pharma Drama
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video we are going to talk about some basic science – literally,…
Melt Fusion Techniques for Solubility Enhancement: A Comparison of Hot Melt Extrusion and KinetiSol®…
A successful candidate for oral drug delivery needs to possess adequate solubility and dissolution rate to elicit its therapeutic action. Extensive research is being carried out to enhance the solubility of poorly soluble drugs through a…
StarLac – MEGGLE’s co-processed lactose grades for direct compression
General Information
Direct compression (DC) tablet manufacture is a popular choice because it provides the least complex, most cost effective process to produce tablets compared to other tablet manufacturing approaches. Manufacturers…
Elucidation of lactose fine size and drug shape on rheological properties and aerodynamic behavior…
Pulmonary drug delivery has gained great attention in local or systemic diseases therapy, however it is still difficult to scale-up DPI production due to the complexity of interactions taking place in DPI systems and limited understanding…
Development of Inline Near-Infrared Spectroscopy Method for Real-Time Monitoring of Blend Uniformity…
Blending is a critical intermediate unit operation for all solid oral formulations. For blend uniformity testing, API content in the blend must be quantified precisely. A detailed study was conducted to demonstrate the suitability of inline…
Enhancement of the Bioavailability and Anti-Inflammatory Activity of Glycyrrhetinic Acid via Novel…
Glycyrrhetinic acid (GA) is an anti-inflammatory drug with potential for development. However, the poor solubility of GA in water leads to extremely low bioavailability, which limits its clinical applications. Solid dispersions have become…
3D printing for the development of implantable devices for cardiovascular disease treatment
Additive manufacturing (also known as 3D printing) has proven to be an effective technology for pharmaceutical and biomedical applications . Additive manufacturing is a family of technologies used to prepare 3D objects by adding layers of…
Vitamin E TPGS by PMC Isochem
D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS hase interesting properties as a P-gp…
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active…
Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products
Although medicinal natural products and their derivatives have shown promising effects in disease therapies, they usually suffer the drawbacks in low solubility and stability in the physiological environment, low delivery efficiency, side…
Amorphous Solid Dispersions: Role of the Polymer and Its Importance in Physical Stability and In…
Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success. Polymer selection is important for preparing…
Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in…
COVID-19 pandemic has accelerated the development of vaccines against its etiologic agent, SARS-CoV-2. However, the emergence of new variants of the virus lead to the generation of new alternatives to improve the current sub-unit vaccines…