Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Innovation in Paediatric Drug Delivery with miniMist®
What is miniMist®?
miniMist® is an inhalation device for children that makes inhalation of pharmaceuticals easy and highly effective using gold standard methods.
miniMist® uses break-through technology and delivers treatments in a…
Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression
Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) was used as a model drug to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation…
Chitosan Based MicroRNA Nanocarriers
Vectorization of microRNAs has shown to be a smart approach for their potential delivery to treat many diseases (i.e., cancer, osteopathy, vascular, and infectious diseases). However, there are barriers to genetic in vivo delivery regarding…
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
Since the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics for patient healthcare has become widely accepted. Lipid nanoparticles (LNPs) are currently the most advanced nanocarriers…
What is an acid?
An explanatory video by Prof. Simon Gaisford - Pharma Drama
Welcome to Pharma Drama, the channel where we look at the science of healthcare and healthcare products. In this video I want you to Get Acids Sorted! So all you need to do…
Recent advances in 3D printing for floating drug delivery platforms
Floating drug delivery is a gastro-retentive delivery system offering an advantage for poor-bioavailability drugs, which have low absorption in the upper gastrointestinal tract. This system can be administered effectively, increasing…
Ocular Delivery of Quercetin Using Microemulsion System: Design, Characterization, and Ex-vivo…
Background:
The goal of this research was to design and characterize quercetin microemulsions (MEs) to resolve water solubility issues related to quercetin and improve transcorneal permeation into the eye.
Methods:
MEs were…
Dissolution Behavior of Weakly Basic Pharmaceuticals from Amorphous Dispersions Stabilized by a…
Amorphous solid dispersions (ASDs) are a well-documented formulation approach to improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However, weakly basic compounds can complicate standard approaches to ASDs due to…
Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems
Arthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously…
Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the…
In recent years, the treatment of bacterial skin infections has been considered a major healthcare issue due to the growing emergence of antibiotic-resistant strains of Staphylococcus aureus. The incorporation of antibiotics in appropriate…
Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into…
Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product…
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include…
Evaluation of the Formulation Parameter-Dependent Redispersibility of API Nanoparticles from Fluid…
The production of nanosuspensions of poorly soluble active pharmaceutical ingredients (API) is a popular technique to counteract challenges regarding bioavailability of such active substances. A subsequent drying of the nanosuspensions is…
Evaluation of cilazapril release profiles with the use of lignin-based spherical particles
The main focus of this study is the preparation of lignin-based spherical particles as drug delivery systems. First, particles were prepared with the use of kraft lignin and the cationic surfactant hexadecyl (trimethyl)ammonium bromide…
A self-emulsifying omega-3 fatty acids delivery system for enhanced gastro-intestinal absorption in…
Omega-3 fatty acids have many health benefits as they help to prevent and treat coronary artery disease, hypertension, diabetes mellitus, arthritis, and autoimmune disorders. Omega-3 fatty acids miscible in lecithin were found to…
Aero Flo®by Kerry – Inhalation Grade Lactose
Dry Powder Inhalers (DPI) and Lactose
Using a dry powder inhaler (DPI) for drug delivery can provide many advantages over traditional oral delivery of pharmaceuticals. DPI’s also offer advantages over older respiratory delivery methods…
In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro…
PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives
Research on cancer treatment is always of great importance because of the extensive and difficult treatment options and side effects of chemotherapeutic agents. Due to this, novel techniques for cancer treatment are the need of the day.…
Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced…
COVID-19 is marked by extensive damage to the respiratory system, often accompanied by systemic manifestations, due to both viral cytopathic effects and hyperinflammatory syndrome. Therefore, the development of new therapeutic strategies or…
isodel PAA – PMC Isochem as CDMO for PolyAmino Acids
See in the following the overview on the usage fields of polyamino acids and the service spectrum of PMC Isochem as CDMO in this area:
Why PolyAmino Acids - PAA
Functional Excipients
Biodegradable Polymers
Drug Delivery…
Extreme Extensibility in Physically Cross-Linked Nanocomposite Hydrogels Leveraging Dynamic…
Abstract
Designing yield stress fluids to exhibit desired functional properties is an integral challenge in many applications such as 3D printing, drilling, food formulation, fiber spinning, adhesives, and injectable biomaterials.…
3D printing of bioactive materials for drug delivery applications
Introduction
Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can…
Enhancing antimicrobial activity of β-lactam antibiotic via functionalized mesoporous carbon-based…
Bacterial immunity to antibiotics is currently increasing as a result of inadequate drug use and the generation of antimicrobial resistance. Developing new antibiotics is challenging, hence suitable carriers are sought to enhance activity…
The Role of Excipients in Liquisolid Technology
This article gives criteria for choosing excipients in liquisolid technology. Liquisolid technology is applicable for non polar drugs by converting drug solution into dry free flowing powder. Patient compliance is more in oral route of…
Specific Excipient Requirements in Continuous Tablet Manufacturing
Abstract
Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing.
Although traditional processes like direct compression, roller compaction, or wet granulation are used within the continuous…
Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis…
Osteoarthritis (OA) is a prevalent degenerative disease that has a significant impact on patients' lives. Celecoxib (CXB) is now primarily used to treat OA with oral dosing. CXB's limited water solubility, on the other hand, restricts its…
Excipients for veterinary application – IOI Oleo
See an overview of the IOI Oleo specialties for Veterinary Applications.
They are used for companion as well as for farm animals in following uses:
• Injectables - SC and IM
• Infusions - IV
• Oral (e.g. paste, drench)
• Pour-on…
The Impact of the Oil Phase Selection on Physicochemical Properties, Long-Term Stability, In Vitro…
A nanotechnology-based approach to drug delivery presents one of the biggest trends in biomedical science that can provide increased active concentration, bioavailability, and safety compared to conventional drug-delivery systems.…
Telmisartan Tablets Repackaged into Dose Administration Aids: Physicochemical Stability under…
Abstract
Dose administration aids (DAAs) are commonly used to assist patients with chronic disease to manage multiple medications and thus improve adherence. Several brands of telmisartan, commonly prescribed for hypertension, are…
Effect of particle characteristics and foaming parameters on resulting foam quality and stability
In this study, the effects of ten different food-grade particles on bubble quality and stabilization of particle-stabilized food foams in batch and continuous foaming with and without polyglycerol ester (PGE) as an emulsifier were…
Peptide-Functionalized Nanoemulsions as a Promising Tool for Isolation and Ex Vivo Culture of…
Circulating Tumor Cells (CTCs) are shed from primary tumors and travel through the blood, generating metastases. CTCs represents a useful tool to understand the biology of metastasis in cancer disease. However, there is a lack of…
Hydroxypropyl cellulose/Polyvinylpyrrolidone Matrix Tablets Containing Ibuprofen: Infiltration,…
The current study aims to prepare the matrix tablet including polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC) and poorly water-soluble ibuprofen (IBU) and to investigate the effect of varying polymer compositions on infiltration…
Near-infrared spectroscopy for rapid identification of pharmaceutical excipients
This study is based on near-infrared spectroscopic detection technology to achieve 100% classification of in-class and out-of-class pharmaceutical ingredients and excipients by support vector machine model.4 types of 8 different…
A review on the latest developments of mesoporous silica nanoparticles as a promising platform for…
Cancer is the second cause of human mortality after cardiovascular disease around the globe. Conventional cancer therapies are chemotherapy, radiation, and surgery. In fact, due to the lack of absolute specificity and high drug…