Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
Hydroxypropyl cellulose/Polyvinylpyrrolidone Matrix Tablets Containing Ibuprofen: Infiltration,…
The current study aims to prepare the matrix tablet including polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC) and poorly water-soluble ibuprofen (IBU) and to investigate the effect of varying polymer compositions on infiltration…
Near-infrared spectroscopy for rapid identification of pharmaceutical excipients
This study is based on near-infrared spectroscopic detection technology to achieve 100% classification of in-class and out-of-class pharmaceutical ingredients and excipients by support vector machine model.4 types of 8 different…
A review on the latest developments of mesoporous silica nanoparticles as a promising platform for…
Cancer is the second cause of human mortality after cardiovascular disease around the globe. Conventional cancer therapies are chemotherapy, radiation, and surgery. In fact, due to the lack of absolute specificity and high drug…
Theoretical evaluation of supersaturation of amorphous solid dispersion formulations with different…
Amorphous solid dispersion (ASD) is a preparation widely used for improving the solubility and low oral absorbability of poorly water-soluble drugs, but the quantitative analysis of its dissolution profiles and its supersaturation status…
Preparation of stable polymer-liposome complexes by a novel approach employing a one-pot method
The purpose of this study was to prepare stable polymer-liposome complexes using a new, improved one-pot method. Complexes prepared by the conventional method were used as reference. The one-pot method combines the vesicle formation and…
Development of a Child-Friendly Oral Drug Formulation Using Liposomal Multilamellar Vesicle…
Many medicines are only available in solid dosage forms suitable for adults, and extemporaneous compounding is required to prepare formulations for children. However, this common practice often results in inaccurate dosing and unpleasant…
Effect of Lipid Vehicles on Solubility, Stability, and Topical Permeation of…
Delta-9-tetrahydrocannabinol (THC) is one of the most effective antinociceptive agents used in the treatment of peripheral neuropathy. THC is highly lipophilic and susceptible to thermal and oxidative degradation. Identifying appropriate…
Lactose Crystalline Monohydrate Family by Kerry
Excipients for direct tabletting, granulation, capsules, sachet filling and inhalation
Product Description
Lactose Overview
Lactose is a disaccharide of glucose and galactose obtained from the whey fraction of bovine milk.…
Outlining Successful Steps for Scale-Up and BLA Filings
In the high-stakes world of microbial biomanufacturing, there are dozens of critical moments and crucial decisions to be made on the path from clinical trials to regulatory approval to commercial manufacturing. Planning and executing both…
Evaluation of Manufacturer-to-Manufacturer Variability of Croscarmellose Sodium: Influence on the…
The present study aimed to investigate if the manufacturer variability of croscarmellose sodium, a superdisintegrant, could have an impact on the dissolution of sitagliptin phosphate (a highly water-soluble drug) and escitalopram oxalate (a…
Hypromellose – Collagen hydrogels/sesame oil organogel based bigels as controlled drug delivery…
The search for novel strategies to formulate bioactive molecules for topical administration is a matter of permanent interest in the pharmaceutical field. As a contribution, the present work deepens the bigels, i.e., matrix-in-matrix…
Phosphate decorated lipid-based nanocarriers providing a prolonged mucosal residence time
The aim of this study was to develop phosphate decorated lipid-based nanocarriers including self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) to extend their mucosal…
Formulation, characterization and in-vitro evaluation of self-nanoemulsifying drug delivery system…
Self-nanoemulsifying drug delivery systems (SNEDDS) are most commonly used lipid-based drug delivery systems for bioavailability enhancement. Mostly SNEDDS contains high concentrations of synthetic surfactants which may result in gastric…
AKVANO ®: A Novel Lipid Formulation System for Topical Drug Delivery-In Vitro Studies
A novel formulation technology called AKVANO® has been developed with the aim to provide a tuneable and versatile drug delivery system for topical administration. The vehicle is based on a water-free lipid formulation where selected lipids,…
Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for…
The fast elimination of drugs from the cornea is one of many challenges associated with the topical administration of conventional dosage forms. The present manuscript aimed to prepare modified-release inserts containing erythromycin (ERY)…
Radial die wall pressure measurement
Instrumented die is used to measure maximum die-wall pressure (MDP) and residual die-wall pressure (RDP) during powder compaction. This document from MEDELPHARM aims to provide a methodology to characterize powders with this device.…
Moisture Sorption by Polymeric Excipients Commonly Used in Amorphous Solid Dispersions and its…
Moisture sorption by polymeric carriers used for the development of amorphous solid dispersions (ASDs) plays a critical role in the physical stability of dispersed drugs since moisture may decrease glass transition temperature (Tg) and…
Nanostructured lipid carriers and their potential applications for versatile drug delivery via oral…
Abstract
Enteral administration is the most convenient route despite the gastrointestinal physiological barriers. Nanostructured lipid carriers (NLCs) have emerged as a promising strategy for improving therapeutic compound oral…
Histopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in…
Acute lung injury (ALI) is a life-threatening illness which may progress to chronic pulmonary fibrosis (CPF). Resveratrol (RSV), a natural polyphenol, is known to exert several pharmacological effects on lung injury. However, its…
Tablettose – MEGGLE’s agglomerated lactose grades for direct compression
General information
Direct compression (DC) tablet manufacture is a popular choice because it provides the least complex, most cost effective process to produce tablets compared to other tablet manufacturing approaches. Manufacturers can…
Neither too little nor too much: finding the ideal proportion of excipients
Excipient’s homogeneity is of paramount importance during the development of pharmaceutical formulations due to its relation to stability, safety and efficacy. A direct and unique approach to evaluate such property is 3D Raman imaging. This…
3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related…
Bacterial infections are a serious healthcare complication in orthopedic and trauma surgery worldwide. Compared to systemic, local antibiotic prophylaxis has been shown to provide a higher antibiotic dose and bioavailability at the bone…
Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of…
The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an…
Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery
Macrolides are widely used antibiotics with a broad spectrum of activity. The development of drug carriers to deliver this type of antibiotics has attracted much research. The present study aims at developing new swellable dextrin-based…
Effects of amylose and amylopectin molecular structures on starch electrospinning
The role of amylose content in electrospinng starch nanofibres is well understood, but that is not the case for the roles of the molecular structures of amylose and amylopectin. Here, correlations between starch molecular-structure…
Comparative Study of Methods for the Pharmaceutical Preparation and Effectiveness of Darunavir…
Purpose
The aim of this work was to study the effectiveness of various methods for improving the solubility and bioavailability of darunavir by mesoporous carriers and water-soluble polymers in the form of amorphous solid dispersions.…
Lipid-based solubilization technology via hot melt extrusion: promises and challenges
Self-emulsifying drug delivery systems (SEDDS) are a promising strategy to improve the oral bioavailability of poorly water-soluble drugs (PWSD). The excipients of SEDDS enable permeation through the mucus and gastro-intestinal barrier,…
Self-Healing Injectable Hydrogels for Tissue Regeneration
Biomaterials with the ability to self-heal and recover their structural integrity offer many advantages for applications in biomedicine. The past decade has witnessed the rapid emergence of a new class of self-healing biomaterials commonly…
Cubosomes for Enhancing Intestinal Absorption of Fexofenadine Hydrochloride: In situ and in vivo…
Purpose: The aim of this work was to probe cubosomes for enhanced intestinal absorption and oral bioavailability of poorly absorbable fexofenadine HCl (FEX-HCl).
Materials and Methods: Two cubosomal systems were fabricated utilizing…
Investigation of the “Nose-to-Brain” Pathways in Intranasal HupA Nanoemulsions and Evaluation of…
Purpose: While developing huperzine A (HupA) to explore new approaches to treating Alzheimer’s disease (AD), intranasal administration was proposed as an alternative route to deliver drugs into the brain. This study aimed to prepare…
Microspheres for targeted drug delivery- A review on recent applications
Microspheres are one of the most explored drug carriers for site-specific delivery of cargoes in a controlled and sustained manner. They are biocompatible, biodegradable, and are capable of surface modifications. A variety of polymers have…
Cyclodextrin superstructures for drug delivery
Cyclodextrins, typically known for their molecular encapsulation properties to form inclusion complexes with guests of adequate size and hydrophobicity, have recently been explored in tridimensional supramolecular assemblies. These…
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense porous network that coats all the exposed epithelia not covered with the skin. The layer provides protection to the underlying gastrointestinal,…
Witepsol – Hard fats for suppositories and ovules by IOI Oleochemical
1| HARD FACTS ABOUT OUR HARD FATS
The brand name WITEPSOL® is synonym for hard fats mainly used in suppositories and ovules.
Development and production of WITEPSOL® started back in the 1950s at the former Chemische Werke Witten, now…