Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
New Challenges in Drug Allergy: the Resurgence of Excipients
Purpose of Review
Allergy to excipients is a cause of multidrug allergy and if it is not taken into account, it can lead to unexpected severe reactions. If an excipient allergy is suspected, an accurate examination followed by…
Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for…
Objective
The therapeutic options for severe asthma are limited, and the biological therapies are all parenterally administered. The purpose of this study was to formulate a monoclonal antibody that targets the receptor for IL-4, an…
Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical…
Poly(acrylic acid) (PAA) is a water-soluble synthetic polymer that exhibits bioadhesive properties and has been applied in various novel medical devices, such as drug-delivery carriers and hemostatic agents. PAA forms a water-insoluble…
General Characteristics, Biomedical and Dental Application, and Usage of Chitosan in the Treatment…
The aim of this narrative review was to present research investigating chitosan, including its general characteristics, properties, and medical and dental applications, and finally to present the current state of knowledge regarding the…
Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends
The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties…
Formulation of sustain release matrix tablet of anti-anginal drug based on Eudragit L 100-55:…
This study aims to design and evaluate oral sustained release matrix tablets of BCS class 2 anti-anginal drug using Eudragit L 100-55 as the retardant polymer and mannitol as a channeling agent for the delivery of anti-anginal drug as…
Redispersible 3D printed nanomedicines: An original application of the semisolid extrusion technique
Semisolid extrusion is a layer-by-layer 3D printing technique that produces objects from gels or pastes. This process can be carried out at room temperature, without using a light source, and has been explored in pharmaceutics in the last…
Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation…
The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation…
Preparation and Characterization of Clopidogrel Bisulfate-Hydroxypropyl-β-Cyclodextrin Mixed…
The study aimed to increase the intestinal solubility and absorption of orally bioavailable clopidogrel-bisulfate (CPB) by complexing with hydroxypropyl-β-cyclodextrin (HCD) to form a binary inclusion complex that was stabilized by Tween 80…
A novel approach to minimize loss of compactibility in a dry granulation process using…
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the…
Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous…
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal…
Evaluation of gravitational consolidation of binary powder mixtures by modified Heckel equation
Consolidation of powders by tapping is an important quality test but it is time and material consuming, which encourages the use of mathematical modelling. This article aims to study this gravitational consolidation dynamics by using nine …
Enhanced Oral Bioavailability of MT-102, a New Anti-inflammatory Agent, via a Ternary Solid…
This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly soluble extract of Isatis indigotica and Juglans mandshurica)…
Application of different models to evaluate the key factors of fluidized bed layering granulation…
Different modeling approaches were used to understand the key factors affecting the outcomes of pulse sprayed FBLG. A large amount of metformin hydrochloride (~83%) was layered onto Cellets® seeds to obtain directly compressible granules.…
Material characterization with an extended Dwell Time compression profile on STYL’ONE NANO
During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design the best formulation possible and…
Low-surfactant microemulsion, a smart strategy intended for curcumin oral delivery
This study aimed to develop a low surfactant concentration curcumin-loaded microemulsion (Curc-ME) having a gastrointestinal pH resistance, intended to prospect its oral use for further curcumin release. The effect of excipients on the…
Compritol-Based Nanostrucutured Lipid Carriers (NLCs) for Augmentation of Zolmitriptan…
Migraine is a severe neurovascular disease manifested mainly as unilateral throbbing headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP) is a biopharmaceutics classification system (BCS) class III medication with an…
Solid dipersions included in poloxamer hydrogels have favorable rheological properties for topical…
Ursolic acid (UA) solid dispersions (SD) formulated into poloxamer-hydrogels were prepared for local treatment of skin inflammations. The hydrogel physico-chemical properties were evaluated, including rheology, in vitro drug permeation and…
Inhaled Therapy for COVID-19: Considerations of Drugs, Formulations and Devices
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for the COVID-19 pandemic, has outspread at full tilt across the world. Although several effective vaccines continue to be deployed, reliable…
PLGA-modified Syloid®-based microparticles for the ocular delivery of terconazole: in-vitro and…
The eye is an invulnerable organ with intrinsic anatomical and physiological barriers, hindering the development of a pioneer ocular formulation. The aim of this work was to develop an efficient ocular delivery system that can augment the…
Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic…
Extensive research is currently being conducted into novel ocular drug delivery systems (ODDS) that are capable of surpassing the limitations associated with conventional intraocular anterior and posterior segment treatments.…
Numerical approach using DEM to control the mechanical strength of pharmaceutical tablets
The present contribution deals with a discrete Element Method (DEM) based on a hybrid particulate lattice model to predict the mechanical strength of pharmaceutical tablets. We consider the classical approach based on the Stress…
Carbopol® Polymers: The Key to Unlocking Patient-Centric OTC Innovation
Did you know that as many as 40% of children have difficulty swallowing a normal-sized pill?
Formulate with patient needs in mind with Lubrizol Life Science Health’s comprehensive excipient range, including Carbopol® polymers, enabling…
Inhalable dry powder mRNA vaccines based on extracellular vesicles
Respiratory diseases are a global burden, with millions of deaths attributed to pulmonary illnesses and dysfunctions. Therapeutics have been developed, but they present major limitations regarding pulmonary bioavailability and product…
Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment
Skin diseases such as atopic dermatitis (AD) are widespread and affect people all over the world. Current treatments for dry and itchy skin are mostly focused on pharmaceutical solutions, while supportive therapies such as ointments bring…
Formulation of Plumbagin Loaded Microemulsion: Evaluation of Anti-rheumatoid efficacy in Wistar Rat…
Rheumatoid arthritis has become a common disease among the elderly. Plumbagin, a plant-derived chemical, has been shown to lower the levels of proinflammatory cytokines and interleukins linked to rheumatoid arthritis progression. The…
Production, physicochemical investigations, antioxidant effect, and cellular uptake in Caco-2 cells…
The purpose of this study was to develop astaxanthin (AST)-loaded self-microemulsifying drug delivery system (SMEDDS) tablets and evaluate their physicochemical and biological properties. The optimized liquid (L)-AST SMEDDS formulation was…
Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and…
Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. Ocimum basilicum (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug,…
In vivo and in vitro per se effect evaluation of Polycaprolactone and Eudragit® RS100-based…
Biodegradable polymeric nanocapsules (NC) present incredible characteristics as drug nanocarriers that optimize drug targeting. However, However, a more detailed isolated effect of polymer-based nanoparticles as drug carriers is required.…
Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric…
The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64 (KVA64), and glutaraldehyde to ameliorate stomach specific floating microspheres (SSFM) using domperidone (DoN) to increase in vivo bioavailability and…
Why not choose DC co-processed excipients in your ODT formulation?
Direct compression (DC) is the simplest process to manufacture tablets. The advantage of DC is that the simplicity of the manufacturing process can reduce manufacturing costs and manufacturing time. On the other hand, we often encounter…
Material characterization with a V-shape compression profile on STYL’ONE NANO
In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet quality such as its hardness depends on…
Filament-based 3D-printing of placebo dosage forms using brittle lipid-based excipients
In order to expand the limited portfolio of available polymer-based excipients for fabricating three-dimensional (3D) printed pharmaceutical products, Lipid-based excipients (LBEs) have yet to be thoroughly investigated. The technical…
Efficient delivery of abciximab using mesoporous silica nanoparticles: in-vitro assessment for…
Abciximab (ABX) is a chimeric monoclonal antibody reported for antithrombotic activity but their delivery remains challenging due to its poor stability in a biological system. The purpose of this research was to deliver ABX on the target…