Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Impact of alternative lubricants on process and tablet quality for direct compression
Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and dissolution times. In the current study, alternative lubricants to MgSt were compared with regard to…
Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of…
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral…
Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch,…
Development of excipients free inhalable co-spray-dried tobramycin and diclofenac formulations for…
This study aims to investigate the effect of physicochemical properties and aerosol performance of two (2FN) and three-fluid nozzles (3FN) on the inhalable co-formulation of tobramycin and diclofenac dry powders. Combination formulations of…
Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded…
Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively to manage pain and inflammatory conditions. However, the drug possesses poor aqueous solubility (i.e., BCS class II) and a short half-life (3–4 h).…
An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review
Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex,…
Enhancement of the Transdermal Delivery of Nonsteroidal Anti-inflammatory Drugs Using Liposomes…
New hybrid liposomes based on cationic amphiphiles with different structures of the head group (cetyltrimethylammonium bromide (CTAB), 3-hexadecyl-1-hydroxyethylimidazolium bromide (IA-16(OH)),…
Strategies for enhancing the oral bioavailability of cannabinoids
Introduction
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been…
The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low…
Process Monitoring and Control of Drug Fluidized Bed Granulation and Its New Application
Nowadays, fluidized bed granulation is a widely used technique in the pharmaceutical industry. Several factors, including process settings, powder qualities, and binder properties, impact its performance. The monitoring of the fluidized bed…
Combined Curcumin and Lansoprazole-Loaded Bioactive Solid Self-Nanoemulsifying Drug Delivery Systems…
Background:
The current study aimed to design a novel combination of lansoprazole (LNS) and curcumin (CUR) solid oral dosage form using bioactive self-nanoemulsifying drug delivery systems (Bio-SSNEDDS).
Methods:
Liquid SNEDDS were…
From Bitter to Sweet: a preliminary study towards a patient-friendly Praziquantel dosage form
Praziquantel (PZQ) is an antihelmintic drug used worldwide against Schistosomiasis, despite its low solubility, bioavailability and the disgusting taste. This research represents a preliminary screening of 6 selected sweeteners in terms of…
Lipids for solid dosage forms
YOUR FORMULATION CHALLENGE - IOI Oleo SOLUTIONS
According to the Biopharmaceutical Classification System (BCS), more than 70% of the APIs used in pharmaceutical preparations are difficult to formulate due to poor solubility and/or…
Fabrication of a Shell-Core Fixed-Dose Combination Tablet Using Fused Deposition Modeling 3D…
Fixed-dose combinations (FDCs) achieve optimal goals for treatment with minimal side effects, decreased administration of large number of tablets, thus, greater convenience, and improved patient compliance. However, conventional FDCs do not…
3D-printed reservoir-type implants containing poly(lactic acid)/poly(caprolactone) porous membranes…
Implantable drug delivery systems are an interesting alternative to conventional drug delivery systems to achieve local or systemic drug delivery. In this work, we investigated the potential of fused-deposition modelling to prepare…
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot…
Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials increases the requirement for standardized evaluation of possible adverse effects,…
Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both…
Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on…
The effect of granules characters on mechanical properties of press-coated tablets: A comparative…
The aim of this study was to investigate the correlation between critical granules characters (including particle size, surface roughness, and apparent porosity) and mechanical properties of press-coated tablets. Granules of a model…
Nanoemulsion for delivery of anticancer drugs
Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark. This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells andrapidly multiplying cancerous cells produces the most…
Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for the enhancement of TCG solubility and permeability. Herein, we have developed the TCG…
Evonik now offers enteric protected ready to fill capsules EUDRACAP® in IPEC-GMP quality
Highlights
EUDRACAP® functional, ready-to-fill capsules now available for human clinical trials
Supports development and commercialization of complex oral drugs using sensitive molecules, including biologicals
Expands…
Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for…
Local deliver medication in a non-invasive pattern and attaining a long-term sustained release at ocular regions to minimize side effects is fascinating for treatment and precision medicine, but its rational design remains a challenge. The…
Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound…
The acidic pH of healthy skin changes during wound healing due to the exposure of the inner dermal and subcutaneous tissue and due to the potential colonization of pathogenic bacteria. In chronic non-healing wounds, the pH values vary in a…
Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization,…
Esomeprazole magnesium (EMP) is a proton pump inhibitor (PPI) that reduces acid secretion. EMP has a short plasma half-life (approximately 1.3 h); hence, nocturnal acid breakthrough (NAB) frequently occurs, disturbing the patient’s…
Engineered inhalable micro-balloon shaped drug particles for carrier-free dry powder inhalation…
The study presents inhalable balloon-like hollow spherical salbutamol sulfate micro-particles (SSμb) as potential carrier-free alternative to drug-excipient formulation for dry powder inhalation. SSμb is engineered from commercial…
Biochar as a processing additive in poly (butylene adipate-co-terephthalate) (PBAT)
Poly (butylene adipate-co-terephthalate) (PBAT) is a promising alternative to non-biodegradable plastics in agricultural applications. However, it is usually blended with other materials to find a balance of strength, cost, and…
Effect of shape on the physical properties of pharmaceutical tablets
Despite a well-established process understanding, quality issues for compressed oral solid dosage forms are frequently encountered during various drug product development and production stages. In the current work, a non-destructive contact…
On-demand delivery of protein drug from 3D-printed implants
Here, we constructed 3D-printed multiunit implants to enable remote light-controlled protein drug delivery in a spatiotemporal manner. Multiunit implants were designed to be 3D printed using polycaprolactone, lauric acid, and melanin as a…
3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review
3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products.…
Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug…
Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of enhancing physical stability, solubilization and absorption of…
Based on functional materials and PLGA for the florfenicol controlled release system and its…
It is widely used PLGA in synthesizing active drug nanoparticles due to its high biocompatibility, biodegradability, and pelletization. In this study with PLGA as the carrier, the florfenicol nanoparticles (FF-PLGA NPs) were investigated to…
Lipid based intramuscular long-acting injectables: current state of the art
Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment effectiveness and adherence for antipsychotic, antiviral and addiction treatments. A range of materials…
Lipid solutions for injectables
IOI Oleo GmbH - EXCIPIENTS FOR INJECTABLE FORMULATIONS
For injectable formulations, the selection of a pure excipient is key to ensure constant drug product quality, stability, efficacy, and finally patient safety.
IOI Oleo offers…
Control strategy definition for a drug product continuous wet granulation process: Industrial case…
This paper describes the specific control strategy of the commercial manufacturing process of an immediate release tablet formulation based on continuous twin-screw wet granulation. This control strategy has been defined by a…