Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
A multivariate formulation and process development platform for direct compression
The efficient development of robust tableting processes is challenging due to the lack of mechanistic understanding on the impact of raw material properties and process parameters on tablet quality. The experimental determination of the…
Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets
Micronized drug powders are generally unsuitable as tableting feed to produce minitablets due to their cohesivity and poor flow. The silicification of fine paracetamol powder (PCMF) with an optimal concentration range of fumed silica (fSi)…
Soft sensor for content prediction in an integrated continuous pharmaceutical formulation line based…
In this study, a concentration predicting soft sensor was achieved based on the Residence Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The RTD was investigated with color-based tracer experiments…
Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled…
Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with promising anticancer therapeutic activities. Nevertheless,…
Making oil and water peacefully coexist – Advanced Emulsion Solutions™
A Croda Pharma Webinar - July 13, 2022
Patient compliance is paramount to the success of topical drug products, and appealing aesthetics are all-important in achieving that compliance. Without an understanding how to employ a variety…
Manufacture of Tablets with Structurally-Controlled Drug Release using Rapid Tooling Injection…
With advancements in the pharmaceutical industry pushing more towards tailored medicines, novel approaches to tablet manufacture are in high demand. One of the main drivers towards micro-scale batch production is the ability to fine-tune…
Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control…
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods…
On the complexity of predicting tablet capping
Predicting tablet defects, such as capping, that might occur during manufacturing, is a challenge in the pharmaceutical industry. In the literature, different parameters were presented to predict capping but no general consensus seems to…
Can Liposomes Survive Inkjet Printing? The Effect of Jetting on Key Liposome Attributes for Drug…
Purpose
Inkjet printing has the potential to enable novel personalized and tailored drug therapies based on liposome and lipid nanoparticles. However, due to the significant shear force exerted on the jetted fluids, its suitability for…
U.S. Government to support expansion of Croda lipid systems capability
Croda International Plc (‘Croda’ or ‘the company’), the company that uses smart science to create high performance ingredients and technologies that improve lives, announces that it has entered into a cooperative agreement with the United…
Real-time coating thickness measurement and defect recognition of film coated tablets with machine…
This paper presents a system, where images acquired with a digital camera are coupled with image analysis and deep learning to identify and categorize film coating defects and to measure the film coating thickness of tablets. There were 5…
Ionic liquids in transdermal drug delivery system: Current applications and future perspectives
The transdermal drug delivery (TDD) shows considerable advantages over other administration pathways. However, conventional enhancing permeation methods face a series of challenges owing to barrier function provided by the skin, of which…
A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions:…
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in recent years, with the potential to improve the apparent solubility and, hence, the oral bioavailability of poorly soluble drugs. The process of…
Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of…
Hydrogel-forming microarray patches (HF-MAPs) offer minimally invasive, pain-free and prolonged drug delivery. These devices are designed to be self-administered and self-disabling, avoiding contaminated sharps waste generation.…
MATERIAL CHARACTERIZATION ON STYL’ONE NANO
Particle morphology influence on tablet characteristics
Excipients, APIs or formulations can be processed in different ways, thus resulting in different properties. Research has been performed to improve powder properties including powder…
Design and pharmacodynamic evaluation of DPK-060 loaded Nanostructured lipid carrier embedded gel…
DPK-060 is a synthetic, 17 amino acid peptide, structurally derived from the human protein kininogen. DPK-060 mainly acts by membrane disruption mechanism, thus demonstrating strong broad-spectrum antimicrobial activity against both…
Particle Agglomeration of Acid-Modified Tapioca Starches: Characterization and Use as Direct…
Acid-modified tapioca starches (AMTSs) possessed good compressibility but showed poor particle flowability for preparing tablets by the direct compression method. The aims of this work were to prepare and characterize AMTS agglomerates…
Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials…
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry’s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality…
Different trends for preparation of budesonide pellets with enhanced dissolution rate
The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP)…
Effect of coating material on dissolution profile of BCS class 1 anti-epileptic extended-release…
The coating is one of the crucial phases in the production of the tablet dosage form with extended-release profiles. Tablet coating has numerous benefits, including disguising the medicine's odor, taste, physicochemical protection, and…
High dose nanocrystalline solid dispersion powder of voriconazole for inhalation
In the current work, we aimed to deliver high dose of voriconazole (VRC) to lung through dry powder for inhalation (DPIs). Furthermore, the research tested the hypothesis that drug nanocrystals can escape the clearance mechanisms in lung by…
Review on Starter Pellets: Inert and Functional Cores
A significant proportion of pharmaceuticals are now considered multiparticulate systems. Modified-release drug delivery formulations can be designed with engineering precision, and patient-centric dosing can be accomplished relatively…
To infinity and beyond: Strategies for fabricating medicines in outer space
Recent advancements in next generation spacecrafts have reignited public excitement over life beyond Earth. However, to safeguard the health and safety of humans in the hostile environment of space, innovation in pharmaceutical…
Active coating of immediate-release evogliptin tartrate to prepare fixed dose combination tablet…
This study was aimed to develop a fixed dose combination (FDC) tablet containing a low dose of evogliptin tartrate (6.87 mg) for immediate release combined with a high dose (1000 mg) of sustained-release (SR) metformin HCl appropriate for…
Development of a novel method for the continuous blending of carrier-based dry powders for…
Twin-screw extruders are useful in tuning certain product characteristics due to the ability to greatly modify screw profiles as well as operating parameters. However, their use has not yet been applied to dry powder inhalation. In this…
Acetaminophen Synthesis and Encapsulation using Safe Mixed-Solvents and Solution Enhanced Dispersion…
Acetaminophen (ACMP) was synthesized in mixed-solvents (H2O-acetone, H2O-dimethyl sulfoxide, H2O-isopropyl alcohol) for purposes of eliminating hazardous dipolar aprotic solvents. The H2O-acetone solvent-pair gave synthesized ACMP yields of…
Freeze-drying of drug nanosuspension– study of formulation and processing factors for the…
The aim of this work was to systematically study the effect of freeze-drying of bottom-up processed cilostazol nanosuspension on the particle size after redispersion. Several different cryoprotectants and concentrations were compared and…
Co–encapsulation of flavonoids with anti–cancer drugs: a challenge ahead
Flavonoids have been considered as promising molecules for cancer treatment due to their pleiotropic properties such as anti–carcinogenic, anti–angiogenic or efflux proteins inhibition. However, due to their lipophilic properties and their…
Development and optimization of solid lipid nanoparticles coated with chitosan and…
Many formulation strategies have been employed to improve ocular bioavailability of topical eye drops. The aim of this study was to develop and evaluate a series of solid lipid nanoparticles coated with poly(2-ethyl-2-oxazoline) and…
Lipid based nanocarriers: Production techniques, concepts, and commercialization aspect
Over the past decade, compared to all other macromolecules lipid-based nanocarriers have proven to be an excellent carrier and delivery system for various pharmaceutical drugs of poor bioavailability. In addition to that, they exhibit…
Diboronate crosslinking: Introducing glucose specificity in glucose-responsive dynamic-covalent…
Dynamic-covalent motifs are increasingly used for hydrogel crosslinking, leveraging equilibrium-governed reversible bonds to prepare viscoelastic materials with dynamic properties and self-healing character. The bonding between aryl…
Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of…
Systemic rheumatoid arthritis treatment has been associated with numerous side effects. We attempted to formulate hyaluronic acid (HA)-coated teriflunomide (TER)-loaded nanostructured lipid carriers (NLCs) that can target inflamed rheumatic…
Bacterial Cellulose – Adaptation of a Nature-Identical Material to the Needs of Advanced…
Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising…
Titanium dioxide (TiO2) as a food additive: Current science report from Canada
This notice from Health Canada on (Titanium Dioxide TiO2) as a food additive was published June 20, 2022. The current outcome in this notice is:
"In summary, the Food Directorate's position is that there is no conclusive scientific…