Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
Research progress of microneedles in the treatment of melanoma
Melanoma is an aggressive malignancy deriving from melanocytes, which is characterized by high tendency of metastases and mortality rate. Current therapies for melanoma, like chemotherapy, immunotherapy and targeted therapy, have the…
Preparation of oral solid dosage forms based on homogenized spot melting technique
Given the benefits of high printing precision and capability, the selective laser sintering technique has been used to manufacture medicines and implants with unique engineering and functional properties. Using homogenized beams with a…
Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)
Poly(lactic-co-glycolic acid) (PLGA) long-acting release depots are effective for extending the duration of action of peptide drugs. We describe efficient organic-solvent-free remote encapsulation based on the capacity of common uncapped…
Rational Selection and Application of Ready-to-Use Formulations for Self-Emulsifying Drug Delivery…
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Continuous Liquid Interface Production of 3D Printed Drug-Loaded Spacers to Improve Prostate Cancer…
Brachytherapy, which is the placement of radioactive seeds directly into tissue such as the prostate, is an important curative treatment for prostate cancer. By delivering a high dose of radiation from within the prostate gland,…
A different approach to immunochemotherapy for colon Cancer: Development of nanoplexes of…
Immune system deficiencies are crucial in the progression of cancer, predominantly because immune cells are not stimulated by cytokines to eradicate cancer cells. Immunochemotherapy is currently considered an innovative approach that…
Fluid properties of various Eudragit® solutions in different solvent systems for periodontal pocket…
Eudragit® are polymethacrylate-based polymers used for pharmaceutical dosage form development especially for sustained drug release devices. Their fluid properties have not been investigated when using organic solvents used in an in…
A Design Approach to Optimise Secure Remote Three-Dimensional (3D) Printing: A Proof-of-Concept…
Telemedicine is defined as the delivery of healthcare services at a distance using electronic means. The incorporation of 3D printing in the telemedicine cycle could result in pharmacists designing and manufacturing personalised medicines…
Long acting injectables for therapeutic proteins
Biotherapeutic development presents a myriad of challenges in relation to delivery, in particular for protein therapeutics. Protein delivery is complicated due to hydrophilicity, size, rate of degradation in vivo, low permeation through…
A study on the effect of biconvex compact shape factors on prediction of dilution potential from…
Background
The purpose of this research was to compare the effect of shape factors of biconvex compacts on prediction of dilution potential from polynomial regression models of area ratio-mass fraction data of novel α-lactose…
Influence of the punch shape on the core and shell structure of press-coated tablets
Press-coated tablets are a key technology to achieve delayed releases in chronotherapeutics. The drug release properties of this kind of tablets are linked to its unique core–shell structure. It is thus important to understand the influence…
Pharmaceutical Applications of Vitamin E TPGS
D-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) has been approved as a safe pharmaceutical adjuvant by FDA, and several drug delivery systems (DDS) based on TPGS have been developed. TPGS properties as a P-gp inhibitor,…
An audit of pharmaceutical continuous manufacturing regulatory submissions and outcomes in the US
Continuous manufacturing (CM) sends materials directly and continuously to the next step of a process, eliminating hold times and reducing processing times. The potential benefits of CM include improved product quality, reduced waste, lower…
Method Development Technology and Optimisation Studies in Famotidine Pellets: An In Vitro Release
Oral medication administration has long been the most convenient and widely utilized technique of drug administration. Pellets are fine powders or granules of bulk pharmaceuticals and excipients agglomerated together. They are made up of…
Ionic Liquids Assisted Topical Drug Delivery for Permeation Enhancement: Formulation Strategies,…
Topical drug delivery provides several benefits over other conventional routes by providing localizing therapeutic effects and also avoids the gastrointestinal tract circumventing the first-pass metabolism and enzymatic drug degradation.…
Quality by Design in Pharmaceutical Development
Design and formulation of an ideal pharmaceutical product is a tedious job for a formulator as it comprises multiple objectives. The traditional method followed for years is not only expensive and time-consuming but also needs a lot of…
Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review
The treatment and management of tuberculosis using conventional drug delivery systems remain challenging due to the setbacks involved. The lengthy and costly treatment regime and patients' non-compliance have led to drug-resistant…
Characterization of phospholipid-modified lung surfactant in vitro and in a neonatal ARDS model…
A strong inflammatory immune response drives the lung pathology in neonatal acute respiratory distress syndrome (nARDS). Anti-inflammatory therapy is therefore a promising strategy for improved treatment of nARDS. We demonstrate a new…
Chitosan/sulfobutylether-β-cyclodextrin based nanoparticles coated with thiolated hyaluronic acid…
Indomethacin (IND) is topically administered for the treatment of the anterior segment diseases such as conjunctivitis, uveitis, and inflammation prevention for post-cataract surgery, as well as posterior segment diseases as macular edema.…
Labrasol Mediated Enhanced Solubilization of Natural Hydrophobic Drugs in Pluronic Micelles:…
In present work, the solubilization of two natural hydrophobic drugs Quercetin (QCT) and Curcumin (CUR) has been systematically investigated in Pluronics (P84, F127, F68) and Pluronics-Labrasol mixed micelles. UV-Visible studies confirmed…
Simplified choice of suitable excipients within biologics formulation design using protein-protein…
Still today, high-concentration protein formulations are often developed based on high-throughput experimental screening approaches. Although likely delivering working formulations, these approaches do not lead to a deep/mechanistic…
Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’…
Electrospinning and wet-spinning have been recognized as two of the most efficient and promising techniques for producing polymeric fibrous constructs for a wide range of applications, including optics, electronics, food industry and…
Capsule-Based dry powder inhaler evaluation using CFD-DEM simulations and next generation impactor…
Capsule-based, single-dose dry powder inhalers (DPIs) are commonly-used devices to deliver medications to the lungs. This work evaluates the effect of the drug/excipient adhesive bonding and the DPI resistances on the aerosol performance…
Effect of carboxymethyl cellulose and polyvinyl alcohol on the cracking of particulate coating…
We investigated the effect of polymers on the cracking of particulate coating layers. Carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA) were used as contrasting polymer additives due to their different surface charges and film…
Material optimization for the development of delayed release formulation using computational tools
The present study involves designing a delayed-release tablet formulation of a drug belonging to BCS class-III further chemically classified as bisphosphonate to improve bioavailability. The typical approach to drug design experimentation…
Binary Isobaric Phase Diagrams of Stearyl Alcohol-Poloxamer 407 Formulations in the Molten and Solid…
Multiparticulate formulations allow for the design of specialized pharmaceutical dosage forms that cater to the needs of a wide range of patient demographics, such as pediatric and geriatric populations, by affording control over the…
Development of Nafamostat Mesylate Immediate-Release Tablet by Drug Repositioning Using…
We aimed to develop nafamostat mesylate immediate-release tablets for the treatment of COVID-19 through drug repositioning studies of nafamostat mesylate injection. Nafamostat mesylate is a serine protease inhibitor known to inhibit the…
Identification of Critical Factors Influencing the In-Vitro Dissolution of Bicalutamide Tablets…
This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the…
Molecular mobility in Soluplus, a polymer with extremely low dynamic fragility; A study by thermally…
This is a thermostimulated depolarization currents (TSDC) study of the slow molecular mobility in Soluplus®, an amorphous polymer used in the production of amorphous solid dispersions for pharmaceutical purposes. We carried out this study…
Soft Robots for the Delivery of Drugs
Miniaturized soft robots compliant to human tissues and organs improve efficiency of drug for both spatial and temporal targeting. Origami robots, sperm robots, nanorobots, robotic capsules, and soft multi-legged robots are some soft robots…
Topical Administration of Drugs Incorporated in Carriers Containing Phospholipid Soft Vesicles for…
This review focuses on the improved topical treatment of various medical skin conditions by the use of drugs delivered from carriers containing phospholipid soft vesicles. Topical drug delivery has many advantages over other ways of…
The Performance of PROSOLV® EASYtab SP in Four Medium-Dose, Direct Compression Formulations with…
In the present study, the performance of PROSOLV® EASYt ab SP was tested in four DC formulations with different model APIs. Each of the selected APIs presented a particular challenge in terms of producing tablets with suitable hardness,…
Hypothermia-Triggered Mesoporous Silica Particles for Controlled Release of Hydrogen Sulfide to…
Despite the fact that heart transplantation (HTx) is a relatively mature procedure, heart ischemic and reperfusion (I/R) injury during HTx remains a challenge. Even after a successful operation, the heart will be at risk of primary graft…
Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting…
Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a potent multistage antimalarial activity. However, it is practically water insoluble. In this study, the hot-melt extrusion (HME) approach was…