Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Development and Optimization of Microballoons Assisted Floating Tablets of Baclofen
The objective of the present study was to develop microballoons aided gastro-retentive floating tablets of baclofen, a skeletal muscle relaxant with a low elimination half-life of ~ 3.5 h. Baclofen floating tablet was prepared to offer…
Melt Extrusion
Techniques to overcome poor aqueous solubility of active pharmaceutical ingredients (APIs) continue to gain interest, with a reported 30% of marketed compounds classified as BCS II and 10% classified as BCS IV. Approximately 70% of new…
Gastroretentive Sustained-Release Tablets Combined with a Solid Self-Micro-Emulsifying Drug Delivery…
Gastroretentive drug delivery systems (GRDDS) get retained in the stomach for a long time, thus facilitating the absorption of drugs in the upper gastrointestinal tract. However, drugs that are difficult to dissolve or unstable in an acidic…
Toxicity of the polymeric excipients in geriatric polypharmacy
Geriatric polypharmacy is already a complicated issue in pharmacotherapy as multiple biological and pharmaceutical factors are involved. Given the fact that the geriatric population, in general, takes more than five medications for multiple…
Injectable Formulations of Poorly Water-Soluble Drugs
Each year, an increasing number of new molecular entities in the drug development pipeline are characterized as having poor water solubility. While solubility limitations are critically important in all formulations, failure to properly…
A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor-Endothelial Cell…
Neuroblastoma (NB) is the most common extracranial tumor in children resulting in substantial morbidity and mortality. A deeper understanding of the NB tumor microenvironment (TME) remains an area of active research but there is a lack of…
Dual Nanostructured Lipid Carriers/Hydrogel System for Delivery of Curcumin for Topical Skin…
This work focuses on the development and evaluation of a dual nanostructured lipid carrier (NLC)/Carbopol®-based hydrogel system as a potential transporter for the topical delivery of curcumin to the skin. Two populations of different sized…
Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a…
Silica nanoparticles were applied as the carrier of chloramphenicol (2,2-dichloro-N-acetamide), and were loaded in a 1% carbopol-based gel (poly(acrylic acid)), which allowed obtainment of an upgraded drug form. The samples of silica…
Pregelatinized Starch as a Binder in Wet Granulation: Optimization of the Incorporation Rate –…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology,…
Background
Cancer remains one of the leading causes of death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use as a chemotherapeutic for management of gastric, breast, neck, head, non-small cell lung cancer and…
Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In…
The aim of the proposed study is to develop a mucoadhesive buccal delivery system for the sustained delivery of metformin (MET) and sitagliptin (SIT) against diabetes mellitus (DM) with improved bioavailability. Polymeric blend of Carbopol®…
Drug powders with tunable wettability by atomic and molecular layer deposition: From highly…
The wettability of pharmaceuticals is a key physical property which influences their dissolution rate, dispersibility, flowability and solid-state stability. Here, we provide a platform of surface nanoengineering methods capable of tuning…
Fabrication and Characterization of Orodispersible Composite Film from Hydroxypropylmethyl…
Crosslinked carboxymethyl rice starch (CLCMRS), prepared via dual modifications of native rice starch (NRS) with chloroacetic acid and sodium trimetaphosphate, was employed to facilitate the disintegration of hydroxypropylmethylcellulose…
Trehalose-releasing nanogels: A step toward a trehalose delivery vehicle for autophagy stimulation
Trehalose has been widely studied as a treatment for a variety of human disorders due to its ability to stimulate autophagy. Trehalose, however, is poorly adsorbed and is hydrolyzed in the intestinal mucosa, and oral delivery requires…
State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the…
Commercially available dry powder inhalers (DPIs) are usually devices in a fixed combination with the intended formulation, and a change in medication by the physician often forces the patient to use a different device, requiring the…
Trojan pH-Sensitive Polymer Particles Produced in a Continuous-Flow Capillary Microfluidic Device…
A facile and robust microfluidic method to produce nanoparticle-in-microparticle systems (Trojan systems) is reported as a delivery vector for the oral administration of active pharmaceutical ingredients. The microfluidic system is based on…
Optimization and evaluation of resveratrol amorphous solid dispersions with a novel polymeric system
The preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, a single polymer often does not bring significantly enhance the…
Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new…
Non-melanoma carcinoma has high incidence rates and has two most common subtypes: basal cell carcinoma and squamous cell carcinoma. This type of carcinoma is usually not fatal; however, it can destroy sensory organs such as the nose, ears,…
Controlled release starch-lipid implant for the therapy of severe malaria
Parenteral depot systems can provide a constant release of drugs over a few days to months. Poly-(lactic acid) (PLA) and Poly-(lactide-co-glycolide) (PLGA) are the most commonly used polymers in the production of these systems. Finding…
Lipid Constituents of Diatoms (Halamphora) as Components for Production of Lipid Nanoparticles
Lipid nanocarriers smaller than 200 nm may be used as pharmaceutical/cosmetic raw materials as they are able to penetrate the skin. The nanostructured lipid carriers (NLCs) based on microalgae oil (Schizochytrium) and lipids extracted from…
The Influence of the Hydroxyl Type on Crosslinking Process in Cyclodextrin Based Polyurethane…
The influence of the hydroxyl groups (OH) type on the polyaddition processes of isocyanates represents a critical approach for the design of multicomponent polyurethane systems. Herein, to prove the effect of hydroxyl nature on both the…
Influence of Excipient Composition on Survival of Vaginal Lactobacilli in Electrospun Nanofibers
The lack of appropriate delivery systems hinders the use of probiotics in the treatment of vaginal infections. Therefore, the development of a new delivery system for the local administration of vaginal probiotics is necessary. In this…
Polymer Coated Polymeric (PCP) Microneedles for Controlled Delivery of Drugs (Dermal and…
Microneedles are used to deliver drugs topically across the skin and mucous membranes. Dissolvable microneedles are made using soluble polymers, which disintegrates in the tissue and release the entire payload instantaneously including the…
Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal…
In this work, we studied the intestinal absorption of a peptide with a molecular weight of 4353 Da (MEDI7219) and a protein having a molecular weight of 11 740 Da (PEP12210) in the rat intestinal instillation model and compared their…
Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems
The essential homeostatic process of dead cell clearance (efferocytosis) is used by viruses in an act of apoptotic mimicry. Among others, virions leverage phosphatidylserine (PS) as an essential “eat me” signal in viral envelopes to…
Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion
A series of thermoresponsive diblock copolymer worm gels is prepared via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate using a water-soluble methacrylic precursor…
SEM/EDX and Raman chemical imaging of pharmaceutical tablets: A comparison of tablet surface…
A better understanding of a pharmaceutical tablet’s microstructure has the potential to unlock the black box between material attributes, process parameters and the critical quality attributes. Microstructure determination requires…
Stimuli-responsive vitamin E-based micelles: Effective drug carriers with a controlled anticancer…
Herein, a series of vitamin E-based TPGS-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(3-vinyl benzaldehyde) block copolymer micelles were synthesized via reversible addition−fragmentation chain-transfer polymerization (RAFT). …
Dissolvable polymer microneedles for drug delivery and diagnostics
Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport a wide selection of active compounds into the skin. To provide an effective therapeutic outcome, μNDs must pierce the human stratum corneum (~ 10 to 20…
Oral delivery of stem-cell-loaded hydrogel microcapsules restores gut inflammation and microbiota
Mesenchymal stem cells (MSCs) are an attractive candidate for the treatment of inflammatory bowel disease (IBD), but their poor delivery rate to an inflamed colon is a major factor hampering the clinical potential of stem cell therapies.…
Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of…
In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and…
Development of Level A in vitro-in vivo correlations (IVIVCs) remains challenging for complex long-acting parenterals, such as poly(lactic-co-glycolic acid) PLGA microspheres. The nature of the PLGA polymer excipient has a dominant…
An insight into gastrointestinal macromolecule delivery using physical oral devices
Oral delivery is preferred over other routes of drug administration by both patients and physicians. The bioavailability of some therapeutics that are delivered via the oral route is restricted due to the protease- and bacteria-rich…
Amorphization of Drugs for Transdermal Delivery -a Recent Update
Amorphous solid dispersion is a popular formulation approach for orally administered poorly water-soluble drugs, especially for BCS class II. But oral delivery could not be an automatic choice for some drugs with high first-pass metabolism…