Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
Amorphization of Drugs for Transdermal Delivery -a Recent Update
Amorphous solid dispersion is a popular formulation approach for orally administered poorly water-soluble drugs, especially for BCS class II. But oral delivery could not be an automatic choice for some drugs with high first-pass metabolism…
Ascertain a minimum coating thickness for acid protection of enteric coatings by means of optical…
Enteric coatings are designed to protect active pharmaceutical ingredients (APIs) against untimely release in the stomach. Acid protection of such coatings depends on the coating layer thickness and integrity, which must be determined in an…
Formulation Development and Optimization of Bioenhanced Sublingual Tablets of Rizatriptan Benzoate…
The drugs belonging to BCS class III, create various challenges for the development of sublingual dosage form due to poor absorption through sublingual mucosa. The sublingual drug delivery is suitable for potent drugs only and prevents the…
Solubility Enhancement of Ibuprofen by Adsorption onto Spherical Porous Calcium Silicate
The solubility of a drug is higher when it is in an amorphous form than when it is in a crystalline form. To enhance the solubility of ibuprofen (IBU), a poorly water-soluble drug, we attempted to adsorb IBU onto spherical porous calcium…
Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration.…
Comparing Environmental Impacts of Direct Compaction versus Wet Granulation Tableting Methods for…
Pharmaceutical tablet productions by direct compaction (DC) are more environmentally sustainable than wet granulation (WG) owed to DC’s lower energy consumption. For drug particles with poor flowability, however, the environmental benefits…
Formulation, Optimization and Evaluation of Ticagrelor Loaded Self Microemulsifying Chewable Tablets
Ticagrelor is a new generation Adenosine diphosphate receptor inhibitor drug which is highly lipohilic having poor aqueous solubility used in the treatment of Acute Coronary Syndrome and prevention of Thrombotic events like Stroke and Heart…
Antioxidants, a safe and viable Inhibition Strategy for Nitrosamine Formation In Drug Products…
Nitrosamines are potential mutagens and need to be controlled in human drug products. Recently, nitrosamine contamination of high-profile drugs has prompted numerous recalls, and increased regulatory assessments for marketed products, as…
Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations
Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including…
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer…
Despite the fact of availability of several treatments for breast cancer, most of them fail to attain the desired therapeutic response due to their poor bioavailability, high doses, non-selectivity and as a result systemic toxicity. Here in…
Mucosal vaccines — fortifying the frontiers
Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. In principle, the induction of adaptive immunity at mucosal sites, involving secretory antibody responses and…
Lactose – a muti-talent Excipient
Meggle took a closer look at the multi-functional excipient lactose. Have a look at the background information for lactose as a pharmaceutical excipient:
Multi-talent milk – Components at a glance
Besides fat, minerals, proteins, and…
Cosolvent and Complexation Systems
Cosolvent and polyethylene glycol (PEG)-based solubilization techniques for the delivery of poorly soluble drugs are discussed in this chapter. The properties of excipients and the physicochemical principles are presented for formulating…
Development of Dapagliflozin Solid Lipid Nanoparticles as a Novel Carrier for Oral Delivery:…
Controlling hyperglycemia and avoiding glucose reabsorption are significant goals in type 2 diabetes treatments. Among the numerous modes of medication administration, the oral route is the most common. Introduction: Dapagliflozin is an…
Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs
Poor aqueous solubility of new chemical entities presents various challenges in the development of effective drug delivery systems for various delivery routes. Poorly soluble drugs that are delivered orally may commonly result in low…
Engineered Microneedles Arrays for Wound Healing
Wound healing is the regenerative process of original skin structure after destructing by different damage sources. Due to their transdermal delivery capability and high specific surface area, microneedles arrays (MAs) have been recognized…
Polymer selection to increase in vitro supersaturation generated by lamotrigine nicotinamide…
Cocrystals can improve drug dissolution by generating supersaturated drug delivery systems. However, supersaturation is a high-energetic state with a tendency to precipitate. Polymers are used as precipitation inhibitors to inhibit…
Development of a mist-based printhead for droplet-based bioprinting of ionically crosslinking…
In this paper, a novel droplet-based printhead is developed for 3D bioprinting of ionically crosslinking hydrogel bioinks. Contrary to previous approaches to droplet-based bioprinting, many of which use a liquid crosslinking agent to…
Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs
The issue of poor aqueous solubility is often a great hitch in the development of liquid dosage forms for those drugs that the Biopharmaceutics Classification System (BCS) includes in classes II and IV. Among the possible technological…
Beyond tablets’ physical characteristics: Incorporating environmental sustainability metrics into…
Despite lubricants' indispensable roles in the production of pharmaceutical tablets. The selection of lubricant for pharmaceutical tableting has been largely empirical, where most tablets are produced using magnesium stearate (MgSt) as the…
Nanoemulgel: For Promising Topical and Systemic Delivery
Nanoemulgel delivery system is a fusion of two different delivery systems, wherein the physical state of drug containing nanoemulsion is changed by adding it to the gel matrix, thus enabling more lipophilic drugs to be used in treatment…
Research progress of natural product-based nanomaterials for the treatment of inflammation-related…
Inflammatory diseases present with dysregulated inflammatory reactions and oxidative stress, resulting in heavy health-associated economic burden to society. Current mainstream therapies, including traditional therapies such as steroids,…
Brain uptake and distribution patterns of 2-hydroxypropyl-ß-cyclodextrin after intrathecal and…
Objectives
Cyclodextrins are increasingly used therapeutically. For example, 2-hydroxypropyl-ß-cyclodextrin (kleptose) is used for the treatment of Niemann–Pick disease. Kleptose crosses the blood–brain barrier poorly, in part because of…
Systematic Development of Solid Lipid Nanoparticles of Abiraterone Acetate with Improved Oral…
In the present work, an attempt was undertaken to improve the oral bioavailability and anticancer activity of abiraterone acetate. Solid lipid nanoparticles (SLNs) were developed using the quality by design (QbD) principles and evaluated…
Super-swelling Hydrogel-forming Microneedle based Transdermal Drug Delivery: Mathematical Modelling,…
Super-swelling hydrogel-forming microneedles (HFMNs) based transdermal drug delivery (TDD) is gaining significant interest due to their non-invasiveness and ability to deliver a wide range of drugs. The HFMNs swell by imbibing interstitial…
Novel Gels: An Emerging Approach for Delivering of Therapeutic Molecules and Recent Trends
Gels are semisolid, homogeneous systems with continuous or discrete therapeutic molecules in a suitable lipophilic or hydrophilic three-dimensional network base. Innovative gel systems possess multipurpose applications in cosmetics, food,…
Women’s preferences and acceptance for different drug delivery routes and products
To use or not to use, that is the first decision to take regarding a drug product. This mandatory step for adherence dictates product efficacy. The determinants for such decision do not only rely on the priority of the therapeutic or…
Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of…
Abstract
The importance of lipid-based formulations in addressing solubility and ultimately the bioavailability issues of the emerging drug entities is undeniable. Yet, there is scarcity of literature on lipid excipient chemistry and…
Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive…
This research demonstrates the use of fused deposition modeling (FDM) 3D printing to control the delivery of multiple drugs containing bioactive self-nano emulsifying drug-delivery systems (SNEDDSs). Around two-thirds of the new chemical…
Dual Drug Loaded Lipid Nanocarrier Formulations for Topical Ocular Applications
Introduction:
Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial…
Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on…
Hard gelatine capsules remain a relevant dosage form for today's pharmaceutical manufacturing. A wide range of colour and print options supports marketing, brand image and patient loyalty. However, the filling of these capsules with various…
Incorporation of itraconazole nano-co-crystals into multiparticulate oral dosage forms
Limited research has been performed on the downstream processing of nano-co-crystal suspensions into solid oral dosage forms. The objectives of this study were to evaluate the impact of three downstream processes (wet granulation, spray…
Preparation of redispersible dry nanoemulsion using chitosan-octenyl succinic anhydride starch…
In this study, chitosan-octenyl succinic anhydride (OSA) starch polyelectrolyte complex (PEC) was investigated as a stabilizer for redispersible dry nanoemulsion. Fenofibrate, a BCS class II lipid-lowering drug, with poor solubility was…
Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration
Intraperitoneal (IP) drug delivery of chemotherapeutic agents, administered through hyperthermal intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosolized chemotherapy (PIPAC), is effective for the treatment of…