Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
Preparation of redispersible dry nanoemulsion using chitosan-octenyl succinic anhydride starch…
In this study, chitosan-octenyl succinic anhydride (OSA) starch polyelectrolyte complex (PEC) was investigated as a stabilizer for redispersible dry nanoemulsion. Fenofibrate, a BCS class II lipid-lowering drug, with poor solubility was…
Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration
Intraperitoneal (IP) drug delivery of chemotherapeutic agents, administered through hyperthermal intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosolized chemotherapy (PIPAC), is effective for the treatment of…
Development of (Inhalable) Dry Powder Formulations of AS01B-Containing Vaccines Using Thin-Film…
AS01B is a liposomal formulation of two immunostimulants namely 3-O-desacyl-4́-monophosphoryl lipid A (MPL) and QS-21. The liposomal formulation of AS01B reduces the endotoxicity of MPL and the lytic activity of QS-21. The AS01B-adjuvanted…
Influence of In Situ Calcium Pectinate Coating on Metoprolol Tartrate Pellets for Controlled Release…
In situ calcium pectinate-coated pellets were proposed by applying an alternate coating method to drug-layered pellets to achieve colon-specific drug delivery. Solution layering of metroprolol tartrate, a water-soluble model drug, on inert…
Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin
The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study, various excipients including surfactants, glycerides and waxes, as well as various drug-delivery systems,…
Oral Thin-films from Design to Delivery: A Pharmaceutical Viewpoint
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric and geriatric patients. Accurate dosing is also an issue for liquid orals (syrup, suspension, emulsion, and so on). Several fast-dissolving drug delivery…
Superiority of Microemulsion-based Hydrogel for Non-Steroidal Anti-Inflammatory Drug Transdermal…
Non-steroidal anti-inflammatory drugs (NSAIDs) represent the foundation of pain management caused by inflammatory disorders. Nevertheless, their oral administration induces several side effects exemplified by gastric ulceration, thus,…
Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications
Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be…
Development of α-Tocopherol Succinate-Based Nanostructured Lipid Carriers for Delivery of Paclitaxel
The management of retinoblastoma (RB) involves the use of invasive treatment regimens. Paclitaxel (PTX), an effective antineoplastic compound used in the treatment of a wide range of malignant tumors, poses treatment challenges due to…
Formulation of immediate release pellets containing famotidine solid dispersions
Famotidine (FM) is a potent H2-receptor antagonist used for the treatment of peptic ulcer. It has a low and variable bioavailability which is attributed to its low water solubility. In this study, the dissolution of the drug was enhanced by…
Expert view: 5 things you need to know about nitrosamines in drug formulation
Nitrosamine risk mitigation is front of mind for many drug formulators following the discovery of N-nitrosodimethylamine (NDMA) in valsartan – a commonly used drug in the treatment of high blood pressure and heart failure.
To learn…
A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion…
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD)…
API-polymer interactions in Sepineo P600 based topical gel formulation – impact on rheology
In the present study, topical gel and emulsion gel were formulated using Acrylamide/ Sodium Acryloyldimethyl taurate copolymer (Sepineo P600) as a gelling agent, and their rheological attributes and physical stability were evaluated upon…
Quality aspects in the development of pelletized dosage forms
The aim of this work was to identify and collate the major common challenges that arise during pellet development. These challenges focus on aspects right from raw material properties until the final drying process of the pelletization. The…
Does manual inspection still make sense?
Manual visual inspection is reliable in only 80% of cases. Such results have been reported by the FMEA (Failure Mode Effect Analysis) inspection process guidelines, taking into account multiple factors, such as time for observation,…
Croda announces the new Pharma business
Croda has announced that its Health Care division will now become Croda Pharma, bringing its core speciality excipient portfolio together with the recent acquisition, Avanti Polar Lipids and its Adjuvant Systems arm, all under one business.…
Sex Differences in Intestinal P-Glycoprotein Expression in Wistar versus Sprague Dawley Rats
Wistar and Sprague Dawley are the most common strains of rat used in pharmaceutical research and are used interchangeably in pre-clinical drug development. No studies have assessed whether Wistar and Sprague Dawley rats are equivalent in…
Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed…
Integrated API and drug product processing enable molecules with high clinical efficacy but poor physicochemical characteristics to be commercialized by direct co-processing with excipients to produce advanced multicomponent intermediates.…
Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical…
Capping is a common defect that can occur during the manufacturing of pharmaceutical tablets. Several studies showed that decreasing the unloading speed of the manufacturing cycle plays a role in the occurrence of such defects. Following…
Effect of Moisture of Pharmaceutical Material MCC Avicel PH102 and Tablet Diameter on the…
This paper focuses on the effect of moisture of powder material on the process of tablet compression and on tablet mechanical strength. The powder used in the experiments was Avicel PH102 microcrystalline cellulose, as it is the most widely…
Top 200 Drugs in 2021
Top 200 Pharmaceuticals by Retail Sales in 2021
Compiled and Produced by M. Haziq Qureshi from the Njarðarson Group (The University of Arizona)
Humira (Immunology) which was on top of the list in 2019 with USD 19.723 billions (USD…
Additive Manufacturing in respiratory sciences – current applications and future prospects
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of customised objects with specific attributes. The versatility of AM procedures and constant technological improvements allow for their application in…
Machine Learning Predicts Electrospray Particle Size
Electrospraying (ES) is a state-of-the-art processing technique with the promise of achieving key nanotechnology and contemporary manufacturing needs. As a versatile technique, ES can produce particles with different sizes, morphologies,…
Spray dried powders for nasal delivery: Process and formulation considerations
Powders for nasal delivery have been recognized as advantageous dosage forms over liquids due to increased stability and residence time on nasal mucosa, with improved bioavailability. They can be manufactured by spray-drying, allowing the…
Influence of the Selected Sieving Parameters on the Sieving Efficiency of Material MCC Avicel PH102
Sieving or screening plays a crucial role in the processing of particulate materials. The sieving process is affected by many factors, including the selection of suitable sieving equipment. Several experiments were carried out to examine…
D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials…
Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the biomedical applications, the biocompatible MZF formulation attracted much attention. In this study,…
Fluid properties and phase transition of antimicrobial eudragit RS/clove oil in situ forming depot
In situ forming depot (ISD) is a liquid drug delivery formulation generating solid depot after injection via a syringe into the body. The 5% w/w doxycycline hyclate (DH)-incorporated poly (ethyl acrylate, methyl methacrylate,…
Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail…
This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and…
Pharmatrans SANAQ® introduces easily soluble CBD powder
Pharmatrans SANAQ® has added to its range of ingredients and excipients an easily soluble and high
purity powder containing between two and six per cent cannabidiol (CBD) as a flavorless
intermediate for food, feed, or cosmetics.
The…
Better fat bubbles could power a new generation of mRNA vaccines
New lipid delivery systems aim to improve potency and reduce side effects
As any dietician will tell you, some fats are good—and that is surely true of the little fatty balls found in two of the world’s most widely used COVID-19…
Co-spray Drying Drugs with Aqueous Polymer Dispersions (APDs)—a Systematic Review
Aqueous colloidal dispersions of water-insoluble polymers (APDs) avoid hassles associated with the use of organic solvents and offer processing advantages related to their low viscosity and short processing times. Therefore, they became the…
Evaluating the effect of kosmotropic inorganic salts in the in vitro dissolution behavior of tablets…
The present study evaluates the effect of kosmotropic inorganic salts in the disintegration time and the in vitro dissolution behavior of tablets containing polyvinylpyrrolidone (PVP)-based amorphous solid dispersions (ASDs). Specifically,…
Transformation of Ritonavir Nanocrystal Suspensions into a Redispersible Drug Product via Vacuum…
The present study explored vacuum drum drying (VDD) as potential drying technique for the solidification of crystalline ritonavir nanosuspensions prepared by wet-ball milling. In detail, the impact of drying protectants (mannitol, lactose,…
Novel preparation approach with a 2-step process for spherical particles with high drug loading and…
A novel approach for preparing drug-containing particles (DCPs) with controlled size distribution and high drug loading was developed using melt granulation. This approach comprises two steps. First, melting component adsorbed particles…