Manufacture of Sulindac-Neusilin® Amorphous Drug Complex Using Hot Melt Extrusion
OVERVIEW
HOT MELT EXTRUSION (HME)
Hot Melt Extrusion (HME) offers several advantages over traditional pharmaceutical processing techniques such as fewer processing steps, continuous operation, little or no solvents, and commercial scale production of solid dispersions with improved bioavailability. New Chemical Entities (NCEs) with solubility…