Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product…
The potential for N-nitrosamine impurities in pharmaceutical products presents a challenge for the quality management of medicinal products. N-Nitrosamines are considered cohort-of-concern compounds due to the potent carcinogenicity of many…
Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based…
The research study reflects the development of novel voriconazole (VCZ) loaded nanoparticles (NPs) for prolonged delivery for the management of ocular diseases. The in situ ophthalmic gel was prepared by incorporating NPs into carboxymethyl…
An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties…
The mRNA vaccine technology has promising applications to fight infectious diseases as demonstrated by the licensing of two mRNA-based vaccines, Comirnaty® (Pfizer/BioNtech) and Spikevax® (Moderna), in the context of the Covid-19 crisis.…
Influence of Oil Phase Surface Properties on the Physicochemical Characteristics of Meloxicam…
Introduction
Preparation of self-microemulsifying drug delivery systems (SMEDDS) is a promising delivery approach for drugs with poor aqueous solubility to enhance their dissolution properties and hence oral bioavailability. The objective…
Importance of Spray–Wall Interaction and Post-Deposition Liquid Motion in the Transport and Delivery…
Nasal sprays, which produce relatively large pharmaceutical droplets and have high momentum, are primarily used to deliver locally acting drugs to the nasal mucosa. Depending on spray pump administration conditions and insertion angles,…
Nanonutraceuticals — Challenges and Novel Nano-based Carriers for Effective Delivery and Enhanced…
Nutraceuticals, the active compounds found abundant in most of the natural products, have shown beneficial effects on human health. Their absorption when consumed is limited owing to their poor solubility and unsuitable chemical and…
Aversion liquid-filled drug releasing capsule (3D-RECAL): A novel technology for the development of…
COVID19 has caused a significant socioeconomic burden worldwide. Opioid crisis was further intensified with the increasing number of opioid overdose/misuse related deaths in last two years. Abusers have adopted newer/efficient methods for…
Exploring bulk volume, particle size and particle motion definitions to increase the predictive…
The definition of the local dissolution environment is central to accurate particle dissolution simulation, and is determined by the apparatus and conditions used. In the flow-through apparatus dissolution occurs in the cell, often in a low…
Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials:…
Because free therapeutic drug molecules often have adverse effects on normal tissues, deliver scanty drug concentrations and exhibit a potentially low efficacy at pathological sites, various drug carriers have been developed for preclinical…
Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use – A focus on…
Currently, there are a few or none marketed gabapentin veterinary products, leading to treatment with compounded dosage forms or off-label use of human-marketed products. With the said approaches, there are significant risks of preparation…
Ensuring Product Stability – Choosing the Right Excipients
The stability of pharmaceuticals is an important product quality attribute. Of the known factors affecting stability, moisture is often perceived as the most common cause of drug degradation by hydrolysis or other reactions facilitated by…
A Multivariate Methodology for Material Sparing Characterization and Blend Design in Drug Product…
This study developed a material and time saving method for powder characterization. Building on an earlier developed raw material property database for use towards development of pharmaceutical dry powder processes, blends were selected in…
Sodium Starch Glycolate as a Superdisintegrant – Review Article
Sodium starch glycolate (SSG) is most widely used excipient in the field of pharmaceutical sciences. SSG is extensively used as a superdisintegrant in different drug formulations. This review article aims to discuss chemistry, synthesis,…
How Croda will support the development of global pharmaceutical excipients?
The importance of excipients and their specialised role in formulation development has been recognised in recent years, whether that be for targeting delivery of the drug, aesthetics of the final formulation, or shelf life of the final drug…
Lonza Expands its Capsugel® Capsule Offering to Include Titanium Dioxide-Free White Hard Gelatin…
Basel, Switzerland, 09 May 2022 – Lonza has expanded its Capsugel® offering with a titanium dioxide-free (TiO2-free) white hard gelatin capsule, fulfilling the evolving demand of its customers to meet new titanium dioxide-free requirements…
Long-acting biodegradable implant for sustained delivery of antiretrovirals (ARVs) and hormones
Women worldwide confront two major reproductive health challenges: the need for contraception and protection from sexually transmitted infections, including Human Immunodeficiency Virus (HIV). Multipurpose Prevention Technologies (MPTs)…
A Critical Overview of the Biological Effects of Excipients (Part II): Scientific Considerations and…
It is now recognized that a number of excipients previously considered to be “inert” have the capacity to alter drug oral bioavailability through a range of in vivo effects. The various mechanisms through which an excipient can affect in…
Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with…
Reliable and stable tablet formulations for rosuvastatin calcium in four strengths: 5 mg, 10 mg, 20 mg and 40 mg have been developed. Rosuvastatin is a cholesterol-lowering statin drug and is known to be unstable during storage. The…
Citric Acid: A Multifunctional Pharmaceutical Excipient
Citric acid, a tricarboxylic acid, has found wide application in the chemical and pharmaceutical industry due to its biocompatibility, versatility, and green, environmentally friendly chemistry. This review emphasizes the pharmaceutical…
A Mucin-Deficient Ocular Surface Mimetic Platform for Interrogating Drug Effects on Biolubrication,…
Dry eye disease (DED) affects more than 100 million people worldwide, causing significant patient discomfort and imposing a multi-billion-dollar burden on global health care systems. In DED patients, the natural biolubrication process that…
Spray-dried indomethacin-loaded polymeric micelles for the improvement of intestinal drug release…
Current study aimed to develop a spray-dried powder containing indomethacin (IND)-loaded polymeric micelles which can be administered perorally as a dissolved powder to enhance the drug release and permeability of the active substance. The…
Prototypes of Nutraceutical Products From Microparticles Loaded With Stilbenes Extracted From Grape…
Grape canes (Vitis vinifera L.) are an important source of bioactive stilbenes, but they are considered a pruning residue. Despite the potential advantages for human health, the low aqueous solubility and stability limits their usage in…
Hydration and dehydration induced changes in porosity of starch microspheres
Characterization and tuning of the porosity of amorphous starch materials are important for many applications, including controlled release of encapsulated proteins. The porosities of these materials in dry and hydrated states can have…
Design of xerogel pill with good swallowing performance through wet milling and drop freeze-drying…
A novel dosage form with dose-adjusting and swallow-assisting functions, named “xerogel pills,” was developed for pediatric or geriatric patients. It is a multiple-unit dosage form in which a single dose is divided into several pills. The…
Harnessing the Antibacterial Properties of Fluoridated Chitosan Polymers against Oral Biofilms
Dental caries are a worldwide endemic chronic disease affecting people of all ages. Due to the limitations of daily used oral hygiene products, there is an unmet need for new, effective, safe, and economic oral products. We have recently…
Titanium dioxide free film coating systems
European Food Safety Authority’s (EFSA) updated assessment on the safety of titanium dioxide as a food additive (published in summer 2021) concludes, that concerns about the genotoxicity of TiO2 particles cannot be excluded. As a result,…
The role of intrinsic fines in the performance change of expired lactose carriers for DPI…
Dry powder inhalation offers a well-established administration route for either local or systemic drug delivery. Lactose-based powder blends still build the basis of respiratory drug delivery, despite of numerous emerging formulation…
Proof-of-Concept for Adjusted Surface Energies and Modified Fines as a Novel Concept in Particle…
Currently marketed dry powder inhaler (DPI) medicine lacks drug delivery performance due to insufficient powder dispersion. In carrier-based blends, incomplete drug detachment is typically attributed to excessive adhesion forces between…
QBD approach for the development of hesperetin loaded colloidal nanosponges for sustained delivery:…
Hesperetin (HT) is a polyphenolic compound with anti-carcinogenic, tumor necrosis, and anti-oxidant properties. The present study reports the fabrication, optimization, and evaluation of HT-loaded nanosponges (HTN)- based gel (HTNG) for…
A coarse-grained parcel method for heat and mass transfer simulations of spray coating processes
The Discrete Element Method (DEM) is commonly used for modeling the flow of particulate materials. Unfortunately, such detailed simulations are computationally very demanding, restricting its use for industrially-scaled processes. The…
Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for…
Objective
The present study was aimed to design and optimize brimonidine tartrate (BRT) loaded cationic-charged liposome formulation with enhanced trans-corneal drug permeation, prolonged corneal residence, and sustained drug release for…
High-amylose maize starch as a novel film former to develop oral films with excellent mechanical…
Aim: The study involved the development and optimization of the fast-dissolving oral films of salbutamol sulfate using high-amylose maize starch (HAMS) as a novel film former by comparison with the HPMC E50 (hydroxy propyl methyl cellulose)…
Nanostructured lipid carrier based dermal gel of cyclosporine for atopic dermatitis-in vitro and in…
Cyclosporine is a gold treatment standard for the treatment of atopic dermatitis. Patients demand extended therapy without adverse effects as atopic dermatitis is a chronic condition. The objective of the study was to formulate and evaluate…
Systematic evaluations of melt-extruded filament for fused deposition modeling-mediated 3D printing
Aim: The significant critical barrier in the ascension of fused deposition modeling (FDM) into a scalable technology is the lack of defined quality benchmarks for validating filament performance. To avoid this issue, we aimed to create a…