Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphous clotrimazole nanosuspension (CLT-NS) consisting of Soluplus® and microcrystalline cellulose. Using the Box-Behnken Design, a systematic evaluation was conducted to analyze the impact of in let temperature, % aspiration, and feed rate on the critical quality attributes…