Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
A Nitrite Excipient Database: A Useful Tool to Support N-Nitrosamine Risk Assessments for Drug…
N-Nitrosamine risk assessment and control have become an integral part of pharmaceutical drug product development and quality evaluation. Initial reports of nitrosamine contamination were linked with the drug substance and its manufacturing…
Particle movement in the spheronizer – Experimental investigations with respect to the toroidal and…
Oberservation of particle movement during wet granulation is crucial for identifying granulation mechanisms, process optimizations and troubleshooting. An example of such a process is spheronization, which is commonly used as a wet…
DoE Based Formulation Development and Characterization of Topical Nanoemulgel of Diacerein: In-Vitro…
Diacerein (DCN) is the class II rhein derivative with low oral bioavailability, although it has good anti-osteoarthritic action. Because of the potential to induce adverse effects when taken orally, the current study focused on producing a…
Manufacturing of mini-tablets. Focus and impact of the tooling systems
Mini-tablets are gaining importance for the pharmaceutical industry as several clinical studies and organizations emphasize the benefits for special patient groups such as paediatrics. Mini-tablets can be manufactured on tablet presses…
Spray-Drying of Hydroxypropyl β-Cyclodextrin Microcapsules for Co-Encapsulation of Resveratrol and…
The synergistic therapeutic benefits of resveratrol (RES) and piperine (PIP) have been proven for the treatment of various diseases. This study reports, for the first time, spray-drying of hydroxypropyl β-cyclodextrin (HP-β-CD)…
Development, In-Vitro and Ex-Vivo Evaluation of Muco-Adhesive Buccal Tablets Of Hydralazine…
Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride.…
UV/VIS imaging-based PAT tool for drug particle size inspection in intact tablets supported by…
The potential of machine vision systems has not currently been exploited for pharmaceutical applications, although expected to provide revolutionary solutions for in-process and final product testing. The presented paper aimed to analyze…
Delamination and wetting behavior of natural hot-melt coating materials
In order to achieve a defined product behavior, the coating of particulate solids is an often used process in the food, chemical, and pharmaceutical industries. The wetting behavior affects the coating quality associated with hot-melt…
pH-responsive silica nanoparticles for the treatment of skin wound infections
Chronic wounds are not only a burden for patients but also challenging for clinic treatment due to biofilm formation. Here, we utilized the phenomenon that chronic wounds possess an elevated local pH of 8.9 and developed pH-sensitive silica…
Matrix Effects on the Performance of Disintegrants in Hydrophobic Tablets – Scientific Poster
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Sources of dissolution variability into biorelevant media
Identifying sources of dissolution variation is often challenging. Biorelevant dissolution media are compositionally complex, can require multiple steps to fabricate, and are utilized across differing laboratories. The objective was to…
Changes in the Structure, Thermodynamic, and Functional Properties of Maize Starch During Mechanical…
The results of research on the structural, thermodynamic, and physicochemical properties of normal maize starch subjected to mechanical processing in a ball mill for different time intervals are presented. It is shown that in the process of…
Quality by design-based optimization of formulation parameters to develop quercetin nanosuspension…
The present study describes the formulation, optimization and characterization of quercetin loaded nanosuspension. The formulation was prepared using liquid antisolvent precipitation technique. Optimization of formulation was done using Box…
Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage…
Superparamagnetic iron oxide nanoparticles (SPIONs) generate heat upon exposure to an alternating magnetic field (AMF), which has been studied for hyperthermia treatment and triggered drug release. This study introduces a novel application…
Synthesis and characterization of cinnamic acid based glyceride and its application for developing…
Curcumin (CU) possesses diverse pharmacological activities while being relatively safe; nevertheless, its clinical application is limited due to its physico-chemical characteristics. This study aimed to synthesize cinnamic acid based…
Formulation, optimization, and in vitro evaluation of anastrozole-loaded nanostructured lipid…
The present study aims to develop and optimize anastrozole (ANZ)-nanostructured lipid carriers (ANZ-NLCs) for improved anticancer efficacy. In a nutshell, ANZ-NLCs were prepared by a 32 factorial design approach through the solvent…
Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for…
The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability of quercetin (QT). Quercetin nanocrystal (QT–NC) was fabricated by high pressure homogenization…
Extrusion and 3D printing of novel lipid-polymer blends for oral drug applications
Lipids are interesting biological materials that can offer a number of pharmaceutical benefits when used as carriers for drug delivery. However, 3D printing of lipids alone by fused deposition processing techniques is very difficult as…
A lipidic mesophase with tunable release properties for the local delivery of macromolecules: the…
Lipid mesophases are able to incorporate and release a plethora of molecules, spanning from hydrophobic drugs to small hydrophilic proteins and therefore they have been widely used as drug delivery systems. However, their 3–5 nm water…
A Quality by Design (QbD) study in direct compression using highly compactible and flowing…
OBJECTIVE
CEOLUSTM UF-711 is highly compactible and flowing microcrystalline cellulose (MCC). While UF-711 has over 1.5 times the compactibility of standard grade PH-102, it has the same flow characteristics as PH-102. This is because the…
Osmolality of Excipients for Parenteral Formulation Measured by Freezing Point Depression and Vapor…
Purpose
To investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions.
Methods
The osmolality was measured by freezing point depression and vapor pressure for…
Cellulose nanofibers/PVA blend polymeric beads containing in-situ prepared magnetic nanorods as dye…
Magnetic beads were developed from polyvinyl alcohol and different amounts of cellulose nanofibers (CNF) by in-situ preparation of iron oxide nanoparticles in an alkaline aqueous medium at room temperature. The CNF were isolated from wheat…
The Effect of Tamping Force on Bi-Layer Tablet Robustness – Scientific poster
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug…
Lovastatin (Lov) is a lipid-lowering agent, with 5% bioavailability (BA) due to extensive first pass metabolism and poor solubility. To enhance dissolution and in vivo effects, Lov solid self microemulsifying drug delivery system (SMEDDS)…
Particle Engineering of Innovative Nanoemulsion Designs to Modify the Accumulation in Female Sex…
Particle engineering of nanosized drug delivery systems (DDS) can be used as a strategic tool to influence their pharmacokinetics after intravenous (i.v.) application by the targeted adaptation of their particle properties according to the…
Formulation and Evaluation of Nano Lipid Carrier-Based Ocular Gel System: Optimization to…
The present research work was designed to prepare Azithromycin (AM)-loaded nano lipid carriers (NLs) for ocular delivery. NLs were prepared by the emulsification–homogenization method and further optimized by the Box Behnken design. AM-NLs…
Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on…
The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its consequences on commonly used Heckel analysis. Compression analysis at compaction pressures…
How to improve topical formulations of poorly-water soluble APIs
Solubility of an Active Pharmaceutical Ingredient (API) in the dosage form is a key parameter in topical formulation. Poor solubility can negatively impact the API drug load, its stability in the dosage form as well as its skin permeation…
Pharma Account Executive, US – Job opportunity with Grace
Built on talent, technology, and trust, Grace is a leading global supplier of catalysts and engineered materials. The company’s two industry-leading business segments—Catalysts Technologies and Materials Technologies—provide innovative…
Rheological Analysis of L-HPC and Suitability for Continuous Manufacturing
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Fast In Vitro Release and In Vivo Absorption of an Anti-Schizophrenic Drug Paliperidone from Its…
The purpose of this study was to develop a drug delivery system for paliperidone (PPD) in order to provide a more effective therapeutic strategy for patients with acute schizophrenia. PPD-loaded Soluplus®/TPGS mixed micelles (PPD-S/T-MM)…
On the Utility of Chemical Strategies to Improve Peptide Gut Stability
Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a key bottleneck in oral peptide drug development. Here, we present a systematic analysis of the gut stability of disulfide-rich peptide…
LYCAGEL® PREMIX – ready-to-use for softgel manufacturing
Roquette’s plant-based softgel offering is expanding to provide manufacturers with a complete ready-to-use LYCAGEL® Premix. Easy to incorporate into existing gelatin softgel manufacturing processes, LYCAGEL® Premix promises all the benefits…
Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to…
Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving…