Pharmacometrics to Evaluate Dosing of the Patient-Friendly Ivermectin CHILD-IVITAB in Children ≥ 15 kg and <15 kg
Abstract
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB on the absorption process and (ii) to evaluate dosing for studies in children < 15…
Sulfobutylation of Beta-Cyclodextrin Enhances the Complex Formation with Mitragynine: An NMR and…
Mitragynine (MTR), the main indole alkaloid of the well-known plant kratom (Mitragyna speciosa), is one of the most studied natural products nowadays, due to its remarkable biological effects. It is a partial agonist on the opioid…
Inhibition of N-Nitrosamine Formation in Drug Products: A Model Study
Nitrosamines, in the absence of toxicological data, are regarded as potential mutagens and need to be controlled at nanogram levels in drug products. Recent high profile product withdrawals have increased regulatory scrutiny of nitrosamine…
Influence of rheological behavior of lactose powders on the weight consistency of tablets –…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded AffinisolTM…
Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), one of the most…
Hydrogel-forming microarray patches with cyclodextrin drug reservoirs to enhance the long-acting…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Half a Century of Technological Advances in Pulmonary Drug Delivery: A Personal Perspective
The last half century of pulmonary product development is reviewed in the context of the main drivers of innovation, technology development, and the advancement of science. A perspective on development timeframes, patent lifetimes, and the…
Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial…
It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were…
Measuring the Disintegration Force Development of Tablets Containing Different Disintegrants
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
The Development of Innovative Dosage Forms of the Fixed-Dose Combination of Active Pharmaceutical…
The development of innovative forms of combination drugs is closely related to the invention of the multilayer tablet press, polymers for pharmaceutical applications, the hot-melt extrusion process, and 3D printing in the pharmaceutical…
Crystallization induced flower-like lactose as potential carriers for dry powder inhaler application
The study documents the flower-like lactose particles as potential carriers to improve Dry Powder Inhaler (DPI) efficiency. The lactose particles (LMx, LMf) are prepared by anti-solvent crystallization and compared with commercial lactose…
Puzzle out Machine Learning Model-Explaining Disintegration Process in ODTs
Tablets are the most common dosage form of pharmaceutical products. While tablets represent the majority of marketed pharmaceutical products, there remain a significant number of patients who find it difficult to swallow conventional…
pH-sensitive liposomes for colonic Co-delivery of mesalazine and curcumin for the treatment of…
The incompetence of the current management of ulcerative colitis (UC) demands novel pharmaceutical techniques and advance therapeutic strategies to facilitate safe and efficacious treatment of the disease. In this quest, mesalazine, a…
Optimization of a film coating formulation for high solid content application suitable for…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
The effect of excipient particle size on the reduction of compactibility after roller compaction
Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet…
Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development
Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of…
Comparative bioavailability study following a single dose intravenous and buccal administration of…
As remdesivir, the first FDA-approved drug for SARS-CoV-2 infection, can be used only for hospitalized patients due to intravenous administration, there is an urgent need of effective oral antiviral formulations to be used at early stage of…
Drug-loaded mesoporous silica on carboxymethyl cellulose hydrogel: Development of innovative 3D…
3D printing has been explored as an emerging technology for the development of versatile and printable materials for drug delivery. However, the alliance of 3D printing and nanomaterials has, to date, been little explored in pharmaceutics.…
Investigating parameters that influence tablet logo bridging
The effect of a number of pan coating process parameters on the incidence of tablet logo bridging were investigated in this study. Parameters investigated included spray rate, pan speed, process air temperature, atomization and pattern air…
Using natural excipients to enhance the solubility of the poorly water-soluble antiretroviral,…
The anti-retroviral drug efavirenz (EFV) exhibits poor aqueous solubility which renders pharmaceutical formulation challenging. During a pre-formulation phase, involving spray drying of EFV for pediatric dosage form development, the…
Preparation and Evaluation of Extended-Release Nanofibers Loaded with Pramipexole as a Novel Oral…
Purpose
Pramipexole (Prami) is renowned as one of the most widely used drugs in the treatment of Parkinson’s disease. This study aimed to prepare slow-release nanofibers of Prami to reduce (or control) the release rate of the drug from the…
Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil…
Abstract
Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from…
In Vitro Evaluation of a Foamable Microemulsion Towards an Improved Topical Delivery of Diclofenac…
Topical microemulsion (ME) might provide a novel and advanced transdermal delivery system due to the enhances of drug solubility and permeability across the stratum corneum. Foams are topical delivery systems that have excellent patient…
Formulation and Evaluation of Transdermal Gel Containing Tacrolimus-Loaded Spanlastics: In Vitro, Ex…
Our goal was to prepare Span 60-based elastic nanovesicles (spanlastics (SPLs)) of tacrolimus (TCR) using the adapted ethanol injection method, characterize them, and evaluate their ability to improve the transdermal permeation of the…
Development of in silico methodology for siRNA lipid nanoparticle formulations
Small interfering RNA (siRNA) gene silencing therapy has great potential for treating multiple diseases. The lipid nanoparticle (LNP) technology for siRNA delivery succussed in clinical treatment. However, the formulation design of…
An Enhanced Stacking Ensemble Method for Granule Moisture Prediction in Fluidized Bed Granulation
Moisture is a crucial quality property for granules in fluidized bed granulation (FBG) and accurate prediction of the granule moisture is significant for decision making. This study proposed a novel stacking ensemble method to predict the…
Rapid Near Infrared Inspection of tablets
The new CUB-20 inspection machine from Pharma Technology was launched in April 2021 and provides comprehensive, non-destructive prediction of the API fraction in tablets. Combining innovative Laser Scanner with NIR multipoint technology and…
The Effect of Particle Size on The Sublimation of Butylhydroxytoluene in Tablets
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
CDMOs for Biologics – Overview
Apart from the fact that there are many different types of biologic products, at the moment there are not too many CDMOs able to manufacture drug substance and then produce a product, let alone that there are some CDMOs that don’t have…
Dabigatran Formulation for Oral Administration – an Evaluation
Dabigatran etexilate mesylate is a pro-drug of Dabigatran – a BSC Class II drug used as anti-coagulant in deep vein thrombosis as a direct thrombin inhibitor. Due to increasing solubility in the acidic regime, tartaric acid pellets (TAP)…
A Novel Faster-Acting, Dry Powder-Based, Naloxone Intranasal Formulation for Opioid Overdose
Objective
To examine the pharmacokinetics and safety of FMXIN001, a new intranasal powder-based naloxone formulation, in comparison to Narcan® nasal liquid spray.
Methods
FMXIN001, was developed by blending drug microspheres with…
3D printed dexamethasone-loaded punctal plugs for dry eye disease
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
A Comprehensive Review of Patented Technologies to Fabricate Orodispersible Films: Proof of Patent…
Orodispersible films (ODFs)are ultra-thin, stamp-sized, rapidly disintegrating, and attractive oral drug delivery dosage forms best suited for the pediatric and geriatric patient populations. They can be fabricated by different techniques,…
Fused deposition modelling for the development of antiplatelet materials for cardiovascular…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Semi-solid extrusion 3D printing of starch-based soft dosage forms for the treatment of paediatric…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…