Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
A Comprehensive Review of Patented Technologies to Fabricate Orodispersible Films: Proof of Patent…
Orodispersible films (ODFs)are ultra-thin, stamp-sized, rapidly disintegrating, and attractive oral drug delivery dosage forms best suited for the pediatric and geriatric patient populations. They can be fabricated by different techniques,…
Fused deposition modelling for the development of antiplatelet materials for cardiovascular…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Semi-solid extrusion 3D printing of starch-based soft dosage forms for the treatment of paediatric…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Comparative Study of Powder Carriers Physical and Structural Properties
High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems…
Microemulsions and Nanoemulsions in Skin Drug Delivery
Microemulsions and nanoemulsions are lipid-based pharmaceutical systems with a high potential to increase the permeation of drugs through the skin. Although being isotropic dispersions of two nonmiscible liquids (oil and water), significant…
Thermal Analysis Tools for Physico-Chemical Characterization and Optimization of Perfluorocarbon…
Self-emulsifying microbubbles, especially designed to increase the contrast of ultrasound images by the inclusion of perfluorocarbon molecules, have been studied by thermal analysis techniques. The microbubbles were made of a blend of gas…
Scaling up Aqueous Enteric Coating with Hypromellose Acetate Succinate (HPMCAS) – Scientific…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
2D Materials-based Nanomedicine: From Discovery to Applications
Due to their unique physicochemical characteristics, 2D materials have attracted more and more attention in the biomedicine field. Currently, 2D materials-based nanomedicines have been extensively applied in various diseases including…
The beneficial properties of feeding isomalt powder
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Nanocellulose recycled from agro wastes and its application in pharma and other industries
Nanoocellulose, predominantly, is a chain of glucose residue and one of the renewable natural polymer in expanding field of sustainable materials easily obtained from nature. In recent times, nanocellulose is one of the rapidly evolving…
Co-processed excipients: Recent advances and future perspective
The demands on the functionality of excipients are increasing day by day because of the emergence of high-speed tableting machines and the use of direct compression methods for tableting. Co-processing plays an important role in the…
Formulation and in-vitro evaluation of Bosewellia Serrata extract loaded transferosomal gel for…
Objective:
The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome the drawbacks associated with oral administration of Bosewellia serrata…
Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications
Abstract
Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates…
Pectin coated nanostructured lipid carriers for targeted piperine delivery to hepatocellular…
Piperine (PIP) is a herbal drug with well-known anticancer activity against different types of cancer including hepatocellular carcinoma. However, low aqueous solubility and extensive first-pass metabolism limit its clinical use. In this…
AsahiKASEI Europe launches new website!
AsahiKASEI is pleased to announce the launch of our brand new website!
We provide an easy way to learn about our CEOLUS™ products, services and solutions. Asahi Kasei is a leading manufacturer and supplier of functional excipients for …
Pellets 4.0 – Advanced Fluidized Bed Technologies
By Dr. Annette Grave - Glatt Pharmaceutical Services
Fluid bed processes were first developed for the chemical industry to achieve better drying efficiencies than obtained with existing technologies e. g with tray drying. Implementation…
Flow reactor for preparation of lipid nanoparticles via temperature variations
Lipid nanoemulsions and nanosuspensions are used as flavor carriers and bubble stabilizers in soft drinks and foods, as well as delivery vehicles for lipophilic drugs in pharmaceutics. Common techniques for their formation are the…
3D Printed Praziquantel Formulations via Direct Powder Extrusion for the Treatment of…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
Advantages of Mannitol in Pharmaceutical Granulation Processes – A Comparison of Different…
Granulation is employed during production of oral dosage forms to convert small particles of powder ingredients and the active pharmaceutical ingredient (API) into large, free-flowing, dust-free, compressible granules, ensuring uniform…
In Vivo Investigation of (2-Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in…
Spironolactone (SPL), a potent anti-aldosterone steroidal drug used to treat several diseases in paediatric patients (e.g., hypertension, primary aldosteronism, Bartter’s syndrome, and congestive heart failure), is not available in…
Pharmatrans SANAQ® DC customized solutions for DiCOM SANAQ® direct compression applications
Pharmatrans SANAQ® offers a wide range of tailored and customized excipients for solid dosage forms tailored for direct compression (DiCOM) manufacturing processes.
These solutions help overcome a series of industry challenges, such as…
Development of mucoadhesive carrier systems for flavoring agents and cannabidiol
The buccal mucosa represents an attractive site to realize both local and systemic effects. It is easily accessible and transbuccal drug delivery offers the opportunity to increase bioavailability of drugs by avoiding first-pass…
The Effect of Humidity on Tablet Surfaces Containing Different Types of Superdisintegrants –…
The 12th APV PBP World Meeting took place from 28 - 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could…
UK Government to support expansion of Croda’s lipid systems manufacturing facility
Croda International Plc that uses smart science to create high performance ingredients and solutions that improve lives, announces that it has been awarded a £15.9 million grant by the UK Government to expand its manufacturing facility in…
The Impact of the Lamination Pressure on the Properties of Electrospinned Nanofibrous Films
The purpose of this work is to explore the preparation of nanofibrous orally dispersible films (ODFs) by needleless electrospinning from the active pharmaceutical ingredient (API) Tadalafil using particles suspended in a solution of…
Protective coating of highly porous alginate aerogel particles in a Wurster fluidized bed
Alginate aerogel particles were successfully coated with a copovidone and hydroxypropyl cellulose based polymer in a Wurster fluidized bed. The results strongly indicate that the pores of aerogels were not damaged during the process.…
Powder filling of electrospun material in vials: A proof-of-concept study
The present paper reports the powder filling of milled electrospun materials in vials, which contained voriconazole and sulfobutylether-β-cyclodextrin. High-speed electrospinning was used for the production of the fibrous sample, which was…
A Quality by Design (QbD) study in direct compression using the most flowable microcrystalline…
OBJECTIVE
CEOLUSTM UF-702 is the most flowable microcrystalline cellulose (MCC). While UF-702 has higher compactibility than standard grade PH-102, it has the lowest repose angle of known commercial grades of MCC. This is because the…
Poloxamer 188 as Surfactant in Biological Formulations – An Alternative for Polysorbate 20/80?
Surfactants are used to stabilize biologics. Especially, polysorbates (Tween® 20 and Tween® 80) dominate the group of surfactants in protein and especially antibody drug products. Since decades drug developers rely on the ethoxylated…
A perspective on calibration and application of DEM models for simulation of industrial bulk powder…
In recent years, there has been increased focus on the calibration of discrete element method (DEM) models to gain improved confidence in the simulation predictions. However, most recent reports have focused on calibration for real…
Development and Dissolution Study of a β-Galactosidase Containing Drinking Straw
Today, in addition to many different physicochemical and pharmacological properties of the active ingredients and excipients, the developer of a pharmaceutical formulation must take into account several factors during the formulation…
Optimization of the Conditions of Solid Lipid Nanoparticles (SLN) Synthesis
Solid lipid nanoparticles (SLNs) have been synthesized as potential drug delivery systems. They are classified as solid lipid nanocarriers that can successfully carry both hydrophilic and hydrophobic drugs. SLNs are based on a biocompatible…
Phase separation in surfactant-containing amorphous solid dispersions – orthogonal analytical…
Amorphous-amorphous phase separation (AAPS) is an important phase transition process for amorphous solid dispersion (ASD) performance both in terms of drug release as well as physical and chemical stability during storage. Addition of…
Smart Hydrogels for Advanced Drug Delivery Systems
Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering…