Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
Potential Global Regulatory Impact of the EU E171 Ban on Dietary Supplements and Pharmaceuticals…
We have kept reporting on the latest TiO2 developments, from the 2019 ban in France, over the 2021 EFSA decision in food and feed, to our FAQ on TiO2.
To properly address this important topic, we decided to host a panel discussion on…
Can pulmonary RNA delivery improve our pandemic preparedness?
The coronavirus pandemic has changed our perception of RNA medicines, and RNA vaccines have revolutionized our pandemic preparedness. But are we indeed prepared for the next variant or the next emerging virus? How can we prepare? And what…
Starch hydrogels as targeted colonic drug delivery vehicles
Targeted colonic drug delivery systems are needed for the treatment of endemic colorectal pathologies, such as Crohn's disease, ulcerative colitis, and colorectal cancer. These drug delivery vehicles are difficult to formulate, as they need…
Influence of amino acids on the aggregation behavior and drug solubilization of branched block…
Block copolymers and their related structure-performance relationships for controllable drug delivery have gained much attention recently. In this work, multibranched PEO-PPO copolymer M904 was synthesized, which had the same PEO and PPO …
The Role of 3D Printing Technology in Microengineering of Microneedles
Microneedles (MNs) are minimally invasive devices, which have gained extensive interest over the past decades in various fields including drug delivery, disease diagnosis, monitoring, and cosmetics. MN geometry and shape are key parameters…
Modernising Orodispersible Film Characterisation to Improve Palatability and Acceptability Using a…
Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to ease of administration and precise and flexible dose adjustments. ODF fabrication has seen significant advancements with the move…
Comparative study on the real-time monitoring of a fluid bed drying process of extruded granules…
The process of fluidized bed drying of granules was comparatively evaluated by on-line real-time measurements of granule moisture content (MC) using near-infrared spectroscopy (NIR) and audible acoustic emission (AAE). The extruded granules…
Intranasal lipid nanocarriers: Uptake studies with fluorescently labeled formulations
Drug delivery by the intranasal route allows both systemic absorption and non-invasive brain targeting, due to the unique connection provided by the olfactory and trigeminal nerves between the brain and the external environment. Lipid …
Dispensing of minitablets – Has the problem been resolved?
Recently, minitablets have been given extensive coverage in literature, as they are perfectly matched to the current therapy individualization trend. Within this scope, special attention is paid to minitablets that enable convenient drug…
Assessment of pharmaceutical powders flowability and comparative evaluation of lubricants on…
Lubricants have a small appearance but act as a giant frame in flow behavior during dosage form preparation. In the present study, different lubricants were evaluated and compared. Both traditional and advanced techniques were used to…
Enhancement of Tablet Coating using an Innovative Functional Excipient
During formulation of solid dosage forms, film coating is used to improve the appearance and stability of tablets, make them easier to swallow, mask the taste, modify or sustain release, protect the drug from the harsh gastric environment,…
Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated…
Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze drying (SFD) is proposed here as an alternative for the preparation of amorphous, free-flowing…
Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical…
Biopharmaceuticals are formulated using a variety of excipients to maintain their storage stability. However, some excipients are prone to degradation during repeated use and/or improper storage, and the impurities generated by their…
Pain management with transdermal drug administration: A review
Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs…
Kollitab™ DC 87 L – BASF’s premium coprocessed excipient
BASF’s premium coprocessed excipient is optimized for your direct compression processes.
Our scientists carefully designed this best-in-class product to maximize flowability and tablet strength, with a formulation that has high stability…
Current trends in theranostic nanomedicines
Nanomedicine plays a vital role in targeting therapeutics to the desired site of action. Over the years, several nanomedicines, like monoclonal antibodies (Rituximab, Brentuximab Vedotin, Alemtuzumab, etc.), nanostructured lipid carriers,…
Role of arginine salts in preventing freezing-induced increase in subvisible particles in protein…
While arginine hydrochloride (ArgHCl) has emerged as a potential stabilizer of protein drugs in liquid formulations, the purpose of this manuscript was to evaluate its stabilization potential in frozen solutions. The phase behavior of…
Processing of Oilseeds
Edible oils are among essential commodities of the world. In this chapter, the information regarding the status of oilseed production, composition of oilseeds, properties of fats and oils, processing methods of oilseeds, their packaging,…
Taking Vitamin D Supplements to the Next Level with galenIQ™
Although previously seen as a “winter time” supplement when shorter days mean that exposure to natural sunlight is limited, vitamin D is rapidly becoming a year-round topic for many people as consumers are increasingly aware of its role in…
Human organs-on-chips for disease modelling, drug development and personalized medicine
The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under…
Prevention of tablet weight loss and tablet surface abrasion on tablet coating using highly…
OBJECTIVE
When large-size tablets are coated, there are often problems of tablet surface abrasion and tablet weight loss due to coating. For these formulations, CEOLUSTM KG-1000, an extremely highly compactible MCC is an effective tool to…
Modelling the Compaction Step of a Platform Direct Compression Process
The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs. However, it is challenging to extrapolate compaction settings for direct…
Experts panel discussion on the future use of Titanium Dioxide (E171) in Pharma
We have kept reporting on the latest TiO2 developments, from the 2019 ban in France, over the 2021 EFSA decision in food and feed, to our FAQ on TiO2.
To properly address this important topic, we decided to host a panel discussion on…
Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at…
Optimizing processing conditions to achieve a critical quality attribute (CQA) is an integral part of pharmaceutical quality by design (QbD). It identifies combinations of material and processing parameters ensuring that processing…
Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020
Objective
To perform a bibliometric analysis in the field of ocular drug delivery research to characterize the current international trends and to present visual representations of the past and emerging trends on ocular drug delivery…
Targeted biomimetic hollow mesoporous organosilica nanoparticles for delivery of doxorubicin to…
Hollow mesoporous organosilica nanoparticles (HMOSNPs) have provided unique opportunities to improve therapeutic efficacy of the encapsulated drugs due to versatile hybrid frameworks and tunable pore sizes, biodegradable nature and…
Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an…
Chronic inflammation is a significant pathological process found in a range of disease states. Treatments to reduce inflammation in this family of diseases may improve symptoms and disease progression, but are largely limited by variable…
Investigation on in-vitro Dissolution and Tableting Properties Enhancement of Etodolac using…
Objectives: The objective of present study was to improve dissolution rate with tableting properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques.
Materials and Methods: The granules of etodolac were…
Paliperidone palmitate as model of heat-sensitive drug for long-acting 3D printing application
In this work, two technologies were used to prepare long-acting implantable dosage forms in the treatment of schizophrenia. Hot-melt extrusion (HME) as well as fused deposition modelling (FDM) were used concomitantly to create personalized…
The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of…
Ensuring sufficient solubility for orally delivered solid dosage forms is a critical step in their development. Most, if not all, of the absorption of these dosage forms takes place in the small intestine, where the drug must be…
Webinar: Quality Requirements for Phospholipid Excipients in Liposomal Formulations
The webinar gives an introduction to phospholipids and covers the regulatory requirements for phospholipid excipients in liposomal formulations and how to fulfill them.
The webinar focuses on quality requirements and regulations from…
Quantification of the actual composition of polymeric nanocapsules: a quality control analysis
Nanocapsules (NCs) are drug delivery nanosystems that contain an oily core, stabilized by a surfactant, and surrounded by a polymeric shell. The assembling of the components is based on physical and physicochemical forces, and, hence,…
In Vitro and In Vivo Evaluations of Berberine-Loaded Microparticles Filled In-House 3D Printed…
The low oral bioavailability, short biological half-life, high dose, and frequent dosing of berberine (BBR) contribute to its restricted clinical use despite its extensive pharmacological activity. Thus, the objective of this study was to…
Tailoring Rational Manufacturing of Extemporaneous Compounding Oral Dosage Formulations with a Low…
Low amounts of minoxidil in oral dosage forms are commonly prescribed as anti-alopecic pharmacological treatments. Side effects are usually related to individual susceptibility. However, poor drug content and mass uniformity can lead to a…