Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were…
Tailoring Rational Manufacturing of Extemporaneous Compounding Oral Dosage Formulations with a Low…
Low amounts of minoxidil in oral dosage forms are commonly prescribed as anti-alopecic pharmacological treatments. Side effects are usually related to individual susceptibility. However, poor drug content and mass uniformity can lead to a…
Multifunctional Role of Silica in Pharmaceutical Formulations
Due to the high surface area, adjustable surface and pore structures, and excellent biocompatibility, nano- and micro-sized silica have certainly attracted the attention of many researchers in the medical fields. This review focuses on the…
Pharmaceutical, Biomedical and Ophthalmic Applications of Biodegradable Polymers (BDPs): Literature…
In the last few decades, the interest in biodegradable materials for biomedical applications has increased significantly. Both natural and synthetic biodegradable polymers (BDPs) have been broadly explored for various biomedical…
Thymoquinone-Enriched Naringenin-Loaded Nanostructured Lipid Carrier for Brain Delivery via Nasal…
In the current research, a thymoquinone-enriched naringenin (NGN)-loaded nanostructured lipid carrier (NLC) was developed and delivered via the nasal route for depression. Thymoquinone (TQ) oil was used as the liquid lipid and provided…
Enhanced circulation longevity and pharmacodynamics of metformin from surface-modified…
Metformin hydrochloride (MTH) has been associated with poor/incomplete absorption (50–60%), low bioavailability, short half-life (0.4–0.5 h), high dosage and dose-related side effects. To overcome these barriers and improve oral…
The degradation of poloxamer 188 in buffered formulation conditions
Poloxamer 188 (P188) as a non-ionic surfactant is used in proteinaceous formulations to prevent protein adsorption to hydrophobic surfaces and unfolding at interfaces, preventing the formation of aggregates and particles. Its chemical…
Replacing PEG-surfactants in self-emulsifying drug delivery systems: Surfactants with polyhydroxy…
Aim
Evaluation of different polyhydroxy surfaces in SEDDS to overcome the limitations associated with conventional polyethylene glycol (PEG)-based SEDDS surfaces for intracellular drug delivery.
Highlights
Polyethylene…
Inkjet Printed Melatonin on Poly(vinyl alcohol) Oral Films: Uptake in an Ex Vivo Oral Mucosal…
There is a growing interest in the use of melatonin in preventing radiation-induced mucositis with potential beneficial effects including prevention of mucosal damage, the emergence of ulcers and the loss of proliferative progenitor…
Lipid Excipients for Drug Delivery – Gattefossé’s new product catalogue
Gattefossé's product catalogue has been refreshed. See the updates:
? Inclusion of their excipients launched in 2021: Emulfree® Duo, Gelucire® 59/14 and Labrafac™ MC60.
? Update of US monograph names for Capryol® 90, Capryol® PGMC and…
Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous…
Individual dosing of pharmaceutics and personalized medicine have become important with regard to therapeutic safety. Dose adjustments, biorelevant drug release and combination of multiple active substances in one dosage form for the…
The CEOLUS™ UF Difference Disintegration and Dissolution Profiles
Optimizing a product's disintegration and dissolution profile is a priority in the formulation development of pharmaceuticals. Read on to discover what makes CEOLUS™ different and why you can trust us to take your products to the next…
Disintegration Testing Augmented by Computer Vision Technology
Oral solid dosage forms, specifically immediate release tablets, are prevalent in the pharmaceutical industry. Disintegration testing is often the first step of commercialization and large-scale production of these dosage forms. Current…
Engineering biomolecular systems: Controlling the self-assembly of gelatin to form ultra-small…
The size of nanocarriers determines the biological property of the materials, especially as it relates to intratumoral distribution. Previous research has shown that sizes of 10–50 nm penetrate deep inside the tumor, resulting in better…
Practical and operational considerations related to paediatric oral drug formulation: an industry…
For over 15 years, US and EU regulations ensure that medicines developed for children are explicitly authorised for such use with age-appropriate forms and formulations, implying dedicated research. To shed light on how these regulations…
Technical insight into potential functional-related characteristics (FRCs) of sodium starch…
Functional-related characteristics (FRCs) are properties of excipients that can potentially influence one or more functions of that excipient in the final product. Knowledge of FRCs is important for formulation development and also to…
Inhaled Dry Powder Mannitol Treatment in Pediatric Patients with Cystic Fibrosis: Evaluation of…
Background: Cystic fibrosis (CF) is a genetic disorder, in which defective clearance of airway secretions leads to progressive lung function loss. Inhaled mannitol is used to increase sputum and mucociliary clearance. There are little data…
Functionalization of mesoporous silica nanoparticles through one-pot co-condensation in w/o emulsion
In this work, three different functionalized mesoporous silica nanoparticles (MSNs) were synthesized through the co-condensation synthesis in oil/water emulsion. Hexadecyltrimethoxysilane, triethoxy-3-(2-imidazolin-1-yl)propylsilane and…
Reduction-sensitive mixed micelles based on mPEG-SS-PzLL /TPGS to enhance anticancer efficiency of…
Currently, the drawbacks of the chemotherapy drugs are still demonstrated poor water solubility, systemic toxicity and even multidrug resistance (MDR) in clinical applications. To address these problems, an amphiphilic block polymer …
Effect of zeta potential of innovative lipid nanocapsules on triamcinolone transdermal delivery
Two pegylated lipid nanocapsules for triamcinolone transdermal delivery were designed. Both present a size close to 50 nm and a single monomodal distribution in particle size (PI < 0.2), with a zeta potential of − 20 ± 2 and + 18 ± 1,…
Development of a potential anti-cancer pulmonary nanosystem consisted of chitosan-doped LeciPlex…
A novel self-assembled lecithin-based cationic nanocarrier (LeciPlex) doped with chitosan was prepared to improve Resveratrol solubility and anticancer efficacy. Using on a machine learning method based on regression analysis, LP5 (composed…
Nanocarrier-based dermopharmaceutical formulations for the topical management of atopic dermatitis
Atopic dermatitis (AD) is a chronic disease that affects the skin, and that is characterized by highly itchy inflammation, frequent eczematous lesions, and a fluctuating course. The current treatment consists of a multi-stage approach that…
Development of self-microemulsifying tablets containing dutasteride for enhanced dissolution and…
This study aimed to develop self-microemulsifying tablets containing the hydrophobic drug dutasteride for easy administration and high in vivo absorption. The candidate lipids and surfactants were formulated into a self-microemulsifying…
Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer…
Throughout the female menstrual cycle, physiological changes occur that affect the biodistribution of nanoparticles within the reproductive system. We demonstrate a 2-fold increase in nanoparticle accumulation in murine ovaries and uterus…
Polyurethane foams from vegetable oil-based polyols: a review
Polyurethane is a versatile material that can be converted into various forms according to applications. PU foams or PUFs are the most commonly used polyurethanes. These are materials of low density and low thermal conductivity that make…
Nanocarriers for promoting skin delivery of therapeutic agents
Compared to oral and injectable administration, a dermal and transdermal drug delivery system that can deliver therapeutic molecules to desired target sites with noninvasive, low toxicity, and convenient self-application is a unique method…
HiSORAD™ – Solving content uniformity issues in ODT prepared by direct compression
Introduction
Direct compression is the simplest tableting method, contributing to both energy savings and cost advantages. However, maintaining content uniformity of active pharmaceutical ingredient (API) in tablets prepared by direct…
Towards a better understanding of the role of stabilizers in QESD crystallizations
Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles…
Novel Developments on Stimuli-Responsive Probiotic Encapsulates: FromSmart Hydrogels to…
Biomaterials engineering and biotechnology have advanced significantly towards probiotic encapsulation with encouraging results in assuring sufficient bioactivity. However, some major challenges remain to be addressed, and these include…
Press-Coated Aceclofenac Tablets for Pulsatile Drug Delivery: Formulation and In Vitro Evaluations
The symptoms of some diseases show circadian rhythms, such as the morning stiffness associated with pain at the time of awakening in rheumatoid arthritis. Therapy for such diseases doesn’t require immediate release or sustained release of…
Development of In Vitro Dissolution Testing Methods to Simulate Fed Conditions for Immediate Release…
In vitro dissolution testing is widely used to mimic and predict in vivo performance of oral drug products in the gastrointestinal (GI) tract. This literature review assesses the current in vitro dissolution methodologies being employed to…
Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy
Ivermectin has received worldwide attention as a potential COVID-19 treatment after showing antiviral activity against SARS-CoV-2 in vitro. However, the pharmacokinetic limitations associated with oral administration have been postulated as…
Percolation-based simulation to predict caking kinetics of polydisperse amorphous powders
Caking in amorphous powders compromises their quality during storage. Individual particles absorb water vapor, which changes their viscosity and promotes the formation of sinter bridges. Lumps of particles grow and eventually span the whole…
Pulsatile Delivery System for Antihypertensive Drug
The purpose of present work was to formulate an oral pulsatile drug delivery system to achieve time release of felodipine, based on chronopharmaceutical approach for the treatment of hypertension. System was prepared in the form of two…
Effects of polymer addition on the non-strongly interacting binary co-amorphous system…
Co-amorphous systems have been developed to address the solubility challenge of poorly water-soluble crystalline drugs. However, due to the thermodynamic instability of amorphous forms, amorphization may result in recrystallization during…