Synergistic cryoprotective effect of deaeration and polysorbate 80 on IgG denaturation during thin-film freeze-drying
Polysorbate 80 (PS80) is employed as a cryoprotectant in biotherapeutic formulations to preserve biologics from denaturation during the freezing process. However, excessive quantities of PS80 can lead to stickiness in dry powder, thereby reducing production yields and altering the physical and aerodynamic characteristics of the powder.…