The comparison of melt technologies based on mesoporous carriers for improved carvedilol dissolution
High-shear (HS) melt granulation and hot melt extrusion (HME) were compared as perspective melt-based technologies for preparation of amorphous solid dispersions (ASDs). ASDs were prepared using mesoporous carriers (Syloid® 244FP or Neusilin® US2), which were loaded with carvedilol dispersed in polymeric matrix (polyethylene glycol 6000 or…