Applying the SeDeM Expert Diagram System for Characterization of Multiple Component Powder Mixtures for Fixed-dose Combination Matrix-type Tablet Formulations
Abstract
Background: The SeDeM Expert Diagram System (SeDeM EDS) is an innovative formulation tool that provides an index of compressibility, which can be used to predict a powder’s suitability for direct compression to produce acceptable tablets.
Objective: This study investigated the application of this tool to evaluate multiple component…