Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were…
Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy
Selective laser sintering (SLS) 3D printing is capable of revolutionising pharmaceutical manufacturing, by producing amorphous solid dispersions in a one-step manufacturing process. Here, 3D-printed formulations loaded with a model BCS…
A “Sequential Design of Simulations” approach for exploiting and calibrating discrete element…
The flow behaviours of cohesive particles in the ring shear test were simulated and examined using discrete element method guided by a design of experiments methodology. A full factorial design was used as a screening design to reveal the…
Size-dependent filling effect of crystalline celluloses in structural engineering of composite…
Oleogels are a class of solid-fat mimetics that contain a large fraction of oil. Most of these materials have low stiffness and poor oil-binding capacity at commercially viable concentrations, which limits their application in the food and…
Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous…
Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have low water solubility into high strength intranasal solutions. Hence, the purpose of this work was to review…
Activated Charcoal Dispersion of Carbon Monoxide Prodrugs for Oral Delivery of CO in a Pill
A novel orally bioavailable solid formulation to deliver a gaseous signaling molecule, carbon monoxide (CO), was developed by adsorbing oxalyl saccharin, a newly developed organic CO prodrug, in the activated charcoal (AC). The resulting…
Hybrid Nanobeads for Oral Indomethacin Delivery
The oral administration of the anti-inflammatory indomethacin (INDO) causes severe gastrointestinal side effects, which are intensified in chronic inflammatory conditions when a continuous treatment is mandatory. The development of hybrid…
Effect of Physical Properties and Chemical Substitution of Excipient on Compaction and…
As final attributes of dosage form largely depend on the properties of excipients used, understanding the effect of physicochemical properties of excipients is important. In the present study, six grades of L-HPC with varying degrees of…
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
The poor aqueous solubility of many approved drugs and most new chemical entities poses a challenge to drug delivery scientists working in academic and industrial labs. Despite the high pharmacological activity these drugs may have, their…
Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis…
Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring…
The Value of Bead Coating in the Manufacturing of Amorphous Solid Dispersions: A Comparative…
Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers potential advantages regarding the minimization of physical stability issues, there is still a lack of in-depth understanding of the bead coating…
Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured…
Nose-to-brain drug delivery has been of great interest for the treatment of many central nervous system (CNS) diseases and psychiatric disorders over past decades. Several nasally administered formulations have been developed to circumvent…
Evonik launches new EUDRATEC® technology to improve solubility of oral small molecules
Essen, Germany. Evonik now offers EUDRATEC® SoluFlow, a new microparticle technology to enhance solubility of active pharmaceutical ingredients in oral drug products. This emulsion-based process technology overcomes solubility hurdles that…
Immunotherapy for neuroblastoma using mRNA vaccines
In children, neuroblastoma seems to be the most frequent form of tumor found in the extracranial region, with a wide range of medical outcomes ranging from reduction of the tumor volume with time to even developing into a metastatic form…
Antiviral Drugs in Influenza
Flu is a serious health, medical, and economic problem, but no therapy is yet available that has satisfactory results and reduces the occurrence of these problems. Nearly 20 years after the registration of the previous therapy, baloxavir…
Why 90% of clinical drug development fails and how to improve it?
Ninety percent of clinical drug development fails despite implementation of many successful strategies, which raised the question whether certain aspects in target validation and drug optimization are overlooked? Current drug optimization…
Nanocarrier Systems in Taste Masking
Taste is the most crucial organoleptic parameter affecting patient compliance in the case of drugs with poor palatability. Taste masking is a major challenge for the development of orally ingested active pharmaceutical constituents in the…
Particle engineering in dry powders for inhalation
Drug administration by inhalation is a well-established approach to treat respiratory and systemic diseases. To deliver a drug into the lung dry powder inhalation (DPI) is an advantageous, but yet challenging option. A variety of strategies…
Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine…
Subcutaneous (SC) ketamine has been found to be effective in pain management, though reports of injection site irritation and sterile abscesses exist with currently available ketamine HCl formulations. Such adverse SC reactions are commonly…
Investigation of the effect of polymers on dermal foam properties using the QbD approach
Dermal foams are promising drug delivery systems due to their many advantages and ease of application. Foams are also considered a novelty in the field of dermatology. In particular, they are beneficial for the treatment of skin conditions…
Synthesis and Characterization of Biodegradable Poly(butyl cyanoacrylate) for Drug Delivery…
Poly(butyl cyanoacrylate) (PBCA) is a biodegradable and biocompatible homopolymer which is used as a carrier matrix for drug delivery systems in the pharmaceutical industry. Typically, polymerization is carried out under aqueous conditions…
Current challenges for modern vaccines and perspectives for novel treatment alternatives
With the on-going pandemic, vaccine developing methods have gained attention of the scientific community, specially towards the production, downstream and transport aspects, making it clear that new methods with less complex production…
Microneedle patch as a new platform to effectively deliver inactivated polio vaccine and inactivated…
We recently reported a lack of interference between inactivated rotavirus vaccine (IRV) and inactivated poliovirus vaccine (IPV) and their potential dose sparing when the two vaccines were administered intramuscularly either in combination…
The Role of Excipients in Determining N-Nitrosamine Risks for Drug Products
IPEC (International Pharmaceutical Excipients Council Federation) published a summary position paper on "The Role of Excipients in Determining N-Nitrosamine Risks for Drug Products". This 7-page position paper explains IPEC Federation's…
Multifunctional building elements for the construction of peptide drug conjugates
Engineering of smart building molecules is key basis in designing intelligent drug delivery systems. As an emerging sophisticated delivery system strategy, the powerful functions of peptide drug conjugates (PDCs) are attributed to a smart…
Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties
To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit…
Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral…
Processing Parameters and Ion Excipients Affect the Physicochemical Characteristics of the…
To optimize the characteristics of stereocomplex polylactide-b-polyethylene glycol nanoparticles (SC-PEG NPs) in terms of pharmacokinetics (PK), we chose continuous anti-solvent precipitation with a T-junction as a preparation method and…
Evonik increases global supply of pharma-grade plant-derived cholesterol for mRNA vaccines and gene…
Extra production capacity for PhytoChol® at German site
Meets increasing demand for critical lipid used in mRNA vaccines, gene therapies and other parenteral applications
Strengthens Evonik’s position as system solutions…
Optimization of the Micellar-Based In Situ Gelling Systems Posaconazole with Quality by Design (QbD)…
Background: Fungal ocular infections can cause serious consequences, despite their low incidence. It has been reported that Posaconazole (PSC) is used in the treatment of fungal infections in different ocular tissues by diluting the oral…
Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo…
The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety of symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness and…
Effect of excipient properties and blend ratio on the compression properties of dry granulated…
In this study, the effect of a systematically varied excipient ratio of a plastic and a brittle material, i.e., microcrystalline cellulose (MCC) and crystalline α-lactose monohydrate (LAC), on the compression properties of dry granulated…
Exclusive license for Croda to commercialise SSI’s CAF® vaccine adjuvants
March 3, 2022
Exclusive license for Croda to commercialise SSI’s CAF® vaccine adjuvants
Croda International Plc, which uses smart science to improve lives, announces today that it has entered a strategic collaboration with Statens…
Formulation performance window for manufacturing cellulose-based sustained-release mini-matrices of…
The aim of the proposed work was to develop robust hot-melt extrusion (HME) process for fabricating sustained-release mini-matrices (pellets) of a highly water-soluble drug, tramadol hydrochloride. The current work was designed to identify…
Thiolated Hydroxypropyl-β-cyclodextrin: A Potential Multifunctional Excipient for Ocular Drug…
The goal of this study was the design and evaluation of a thiolated cyclodextrin providing high drug solubilizing and mucoadhesive properties for ocular drug delivery. Hydroxypropyl-β-cyclodextrin (HP-β-CD) was thiolated via a…