Evaluation of the application of polyethylene glycol 8000 as a plasticizer for the development of solid dispersions based on ellagic acid and Eudragit® EPO using hot melt extrusion
Solid dispersion formation by hot melt extrusion (HME) is a widely used formulation strategy to improve the solubility and bioavailability of poorly water-soluble drugs. Despite this, they are limited by various factors such as drug-excipient miscibility, poor stability, limited drug loading and extrudability of physical drug-excipient mixtures. In…