Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were…
Vehicles for Drug Administration to Children: Results and Learnings from an In-Depth Screening of…
Purpose
Mixing with liquids or soft foods is a common procedure to improve acceptability of oral medicines in children but may affect drug stability and the in vivo performance of the administered drug product. The aim of the present study…
Apinovex™ Polymers – Solubility-Enhancing Excipients for Amorphous Solid Dispersions
Lubrizol’s Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray-dried amorphous solid dispersions (ASDs).
Apinovex polymers enable formulators to…
Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings…
We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of hydroxychloroquine, IgG, gp120 fragment (encompassing the CD4 binding…
An overview on dry powder coating in advancement to electrostatic dry powder coating used in…
The protection of pharmaceutical drugs by coating with suitable coating powder polymers plays a crucial role in the pharmaceutical industry. The dry coating is preferred due to its advantages, like reducing the overall coating amount and…
ExciPerience – Where Science meets – March 9 & 10, 2022
The 2nd Edition of ExciPerience starts March 9, 2022 and will bring 24 great speakers covering several aspects on excipients, formulation, drug delivery and other important topics during this event.
AGENDA AND REGISTRATION
The Speeches…
Method Development and Validation of a Near-infrared spectroscopic method for In-line API…
Near-infrared spectroscopy (NIRS) is an excellent process analytical technology (PAT) tool for active pharmaceutical ingredient (API) quantification during fluidized granulation. Therefore, a portable near-infrared spectrometer combined…
Gelatin-Lysozyme Nanofibrils Electrospun Patches with Improved Mechanical, Antioxidant and…
Biopolymeric patches show enormous potential for the regeneration of infarcted myocardium tissues. However, most of them usually lack appropriate mechanical performance, stability in water, and important functionalities; for instance,…
Overcoming Challenges in Ophthalmic Formulations through Polymer Selection – A Closer Look at…
Ophthalmic drug formulations are growing in importance due to the increased prevalence of eye-related
disorders such as diabetic retinopathy and macular degeneration.However, ocular drug delivery is challenging due to unique anatomical and…
Nanocrystals based pulmonary inhalation delivery system: advance and challenge
Pulmonary inhalation administration is an ideal approach to locally treat lung disease and to achieve systemic administration for other diseases. However, the complex nature of the structural characteristics of the lungs often results in…
Development and evaluation of extended release metformin pellets suspended in teneligliptin jelly…
During chronic treatment of diabetes mellitus, a few patients may need combination therapy with metformin hydrochloride (MH). Such combinations are available in the form of tablets. However, the size of these tablets is large and may lead…
Switching from batch to continuous granulation: A Case Study of metoprolol succinate ER tablets
Continuous manufacturing (CM) has been used to produce several immediate release drug products. No extended-release (ER) product manufactured employing CM technology has been approved yet. This study investigated the critical aspects of…
3D printed drug-loaded implantable devices for intraoperative treatment of cancer
Surgery is an important treatment for cancer; however, local recurrence following macroscopically-complete resection is common and a significant cause of morbidity and mortality. Systemic chemotherapy is often employed as an adjuvant…
Preparation of Acetaminophen with Fujicalin® and a comparison of Fujicalin® with other commercially…
Blending and Content Uniformity ofMicronized Low-Density Acetaminophen Comparison of Fujicalin® with Other DCPA's
Fujicalin® is an innovative Dibasic Calcium Phosphate Anhydrous (DCPA) that provides significantly improved compressibility…
The Molded Tablet, a disintegrant-free orally disintegrating tablet, resists thickening…
In clinical practice, a thickening solution is frequently coadministered with medicinal tablets to facilitate swallowing by older patients. This study investigated the effect of thickening solutions on the reduction in drug dissolution from…
Bilayer Buccal Tablets of Furosemide: Design and Evaluation
Aim: In the present study, mucoadhesive bilayer buccal tablets of furosemide were fabricated with the objective of avoiding first-pass metabolism and enhancing the bioavailability along with reducing the dosing frequency.
Methodology:…
Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as…
Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation of solid oral dosage forms requires the drying of PECs,…
Synthesis of mesoporous silica nanoparticles (MSNs)/silver nanoparticles (AgNPs): promising hybrid…
In this article, we report the synthesis of mesoporous silica nanoparticles–silver nanoparticles (MSNs–AgNPs) for use in detection of breast cancer cells. The synthesized MSNs–AgNPs were characterized by transmission electron microscopy…
Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular…
Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the design,…
Nanomechanical testing in drug delivery: theory, applications, and emerging trends
Mechanical properties play a central role in drug formulation development and manufacturing. Traditional characterization of mechanical properties of pharmaceutical solids relied mainly on large compacts, instead of individual particles.…
Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load
Liquisolid systems represent an emerging approach in the preparation of solid dosage forms with liquid lipophilic drug or poorly water-soluble drug solution/suspension in suitable liquid vehicle. This study addresses the lack of data…
Volumetric 3D printing for rapid production of medicines
3D printing (3DP), or additive manufacturing, has been actively investigated as one of the enabling technologies for the impending era of personalized medicines. However, existing 3DP technologies do not afford the speeds required for…
System model driven selection of robust tablet manufacturing processes based on drug loading and…
Mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. A system model of a pharmaceutical…
Intranasal delivery of insulin by self-emulsified nanoemulsion system: In vitro and in vivo studies
The main objective of this research was to develop a self-emulsified nanoemulsion (SEN) dosage form of insulin where insulin is loaded into the lipid phase of the nanoemulsion for enhanced absorption through intranasal delivery. When loaded…
Industry perspective on the use and characterization of polysorbates for biopharmaceutical products…
Polysorbates (PS) are widely used as a stabilizer in biopharmaceutical products. Industry practices on various aspects of PS are presented in this part 1 survey report based on a confidential survey and following discussions by 16 globally…
A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory…
Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from…
Advances in controlled drug delivery to the sinonasal mucosa
Controlled drug delivery is a valuable strategy for increasing local therapeutic concentrations in a sustained manner, particularly in locations that are difficult to access. One such target is the sinonasal mucosa, which can be chronically…
Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of…
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® E, Eudragit® RS,…
Enhancing Stability and Mucoadhesive Properties of Chitosan Nanoparticles by Surface Modification…
Background: The present study aimed to fabricate surface-modified chitosan nanoparticles with two mucoadhesive polymers (sodium alginate and polyethylene glycol) to optimize their protein encapsulation efficiency, improve their mucoadhesion…
Designing electrospun fiber platforms for efficient delivery of genetic material and genome editing…
Electrospun fibers are versatile biomaterial platforms with great potential to support regeneration. Electrospun fiber characteristics such as fiber diameter, degree of alignment, rate of degradation, and surface chemistry enable the…
Lipid-Based Formulations Containing Labrafil M2125-CS: A Deep Investigation on Nanosystem Stability
Labrafil M2125-CS is a non-ionic surfactant component widely used for improving the solubilization of poor water-soluble drugs and as component of lipid-based nanosystem formulation. The aim of this research work was to evaluate in depth…
Spray Drying and Particle Engineering in Dosage Form Design for Global Vaccines
Vaccines are a very important tool in the effort to reduce the global burden of infectious diseases. Modern vaccines can be formulated in several ways to induce specific immunity, including through the use of live bacteria, subunit…
Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung…
It has recently emerged that drugs such as the mTOR inhibitor rapamycin (Rapa) may play a key role in the treatment of airway inflammation associated with lung diseases, such as chronic obstructive pulmonary disease, asthma, and cystic…
Blind-Watermarking – Proof-of-Concept of a Novel Approach to Ensure Batch Traceability for 3D…
Falsified medicines are a major issue and a threat around the world. Various approaches are currently being investigated to mitigate the threat. In this study, a concept is tested that encodes binary digits (bits) on the surface of Fused…
Solubility enhancement – The Interview with Fuji Chemical
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance…