Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were…
Printing Drugs onto Nails for Effective Treatment of Onychomycosis
Inkjet printing (IJP) is an emerging technology for the precision dosing of medicines. We report, for the first time, the printing of the antifungal drug terbinafine hydrochloride directly onto nails for the treatment of onychomycosis. A…
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
For the past several years, dementia, is one of the predominantly observed groups of symptoms in a geriatric population. Alzheimer’s disease (AD) is a progressive memory related neurodegenerative disease, for which the current Food and drug…
Understanding Heat Transfer During the Secondary Drying Stage of Freeze Drying: Current Practice and…
Currently, there is a lack of robust models for secondary drying with comparable accuracy and flexibility as primary drying models. In order to better understand heat transfer during secondary drying, sucrose and mannitol solutions were…
Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In…
This work aimed to develop a new efficient approach for safe treatment of psoriasis. To achieve that, resveratrol-loaded spanlastics (F1-F12) were prepared and evaluated by complete in vitro characterization. The two optimal formulations…
Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed…
The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The…
The Transdermal Delivery of Therapeutic Cannabinoids
Recently, several studies have indicated an increased interest in the scientific community regarding the application of Cannabis sativa plants, and their extracts, for medicinal purposes. This plant of enormous medicinal potential has been…
‘Tablet-in-Syringe’: A Novel Dosing Mechanism for Dysphagic Patients Containing Fast-Disintegrating…
With the ability to fabricate personalized dosage forms and considerably shorter manufacturing time, semisolid extrusion (SSE) 3D printing has rapidly grown in popularity in recent years as a novel, versatile manufacturing method that…
Pulmonary vaccine delivery: An emerging strategy for vaccination and immunotherapy
Vaccination has been known as the most successful health strategy for the prevention of infectious diseases, and their subsequent disability conditions. Conventional vaccination is based on parenteral administration and therefore requires…
Lyophilized tablets of felodipine-loaded polymeric nanocapsules to enhance aqueous solubility:…
The aim of this study was to enhance the physicochemical properties of felodipine through the formulation of lyophilized polymeric nanocapsule tablets. Felodipine was loaded into polymeric nanocapsules composed of Labrafac™ PG (an oil…
A single oral dose of celecoxib-loaded solid lipid nanoparticles for treatment of different…
Schistosomiasis, a neglected tropical parasitic disease, is associated with severe pathology, mortality and economic loss. The treatment and control of schistosomiasis depends mainly on a single dose of praziquantel (PZQ). Drug repurposing…
Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks…
Polymeric micelles (PMs) have been explored pre-clinically for the delivery of chemotherapeutics to treat cancer. Their unique features, such as easy surface functionalization, stimuli-responsiveness, good stability, ability to modify drug…
Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC…
The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important…
Correlation between the powder characteristics and particle morphology of microcrystalline cellulose…
A quantitative approach is described to finding the correlation between the MCC application performance in tablets, which is key to pharmaceutical applications, and two kinds of powder features, 1) physical properties and 2) morphology,…
Experimental Design and Optimization of a Novel Dual-release Drug Delivery System With Therapeutic…
The objective of this study was to develop clarithromycin-loaded lipid nanocarriers and incorporate them into microcapsules for pH-specific localized release of clarithromycin in the Helicobacter pylori microenvironment in order to obtain a…
Systemic delivery of tenofovir alafenamide using dissolving and implantable microneedle patches
The human immunodeficiency virus (HIV) remains a global health concern, with 37.7 million people currently living with the infection and 1.5 million new cases every year. Current antiretroviral (ARV) therapies are administered through the…
Active Machine learning for formulation of precision probiotics
It is becoming clear that the human gut microbiome is critical to health and well-being, with increasing evidence demonstrating that dysbiosis can promote disease. Increasingly, precision probiotics are being investigated as investigational…
Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using…
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary amorphous solid dispersions (SDs) of Coenzyme Q10 (CoQ10), a biopharmaceutics classification…
Pharmatrans specific functional starter cores for improved bioavailability and dissolution
Pharmatrans Sanaq specialized range of pharmaceutical excipients and novel drug vehicles includes pellets to aid design of various types of solid dosage forms.
The range has been extended from standard types of microcrystalline…
Quantifying the Coating Yield by Modeling Heat and Mass Transfer in a Wurster Fluidized Bed Coater
During the coating process of medicines, premature drying of the spray droplets may cause losses, as the droplets do not stick to the product. This work addresses two mechanisms that are central to predicting the heat and mass transfer in…
Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a…
Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the…
The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its Application…
SBECD (Captisol®) with an average degree of substitution of 6.5 sulfobutylether functional groups (SBE = 6.5), is a solubility enhancer for remdesivir (RDV) and a major component in Veklury, which was approved by FDA for the treatment of…
Influence of surface interaction between drug and excipient in binary mixture for dry powder inhaler…
The present study documents the drug-excipient incompatibility in the physical mixtures and its influence on bulk homogeneity and flowability for dry powder inhalers (DPI) applications. Binary mixtures with the model drugs (aceclofenac;…
Kerry announces significant strategic biotechnology acquisitions
15th February 2022: Kerry, the world’s leading taste and nutrition company, has announced that it has made two significant biotechnology acquisitions that will expand its expertise, technology portfolio and manufacturing capabilities. The…
Solubility enhancement – Transform insoluble drugs into stable and efficient formulations
Recent industry trends show many pharmaceutical manufacturers are creating drugs with greater degrees of lipophilicity, higher molecular weight, greater physical form complexity and lower aqueous solubility. Unfortunately, these…
Innovation in tablet hardness testing – one for all including mini tablets!
The AT50 easily handles all your tablets. Designed for the demanding environments of pharmaceutical manufacturing and dusty compression rooms, the benchtop version excels with very short cycle times in your lab. Quickly test batches…
Fast-Dissolving Nifedipine and Atorvastatin Calcium Electrospun Nanofibers as a Potential Buccal…
Geriatric patients are more likely to suffer from multiple chronic diseases that require using several drugs, which are commonly ingested. However, to enhance geriatric patients’ convenience, the electrospun nanofiber system was previously…
Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system
The purpose of the present study was to prepare and evaluate self-emulsifying drug delivery system (SEDDS) of curcumin (Cur) to enhance its solubility and percentage release for the evaluation of anti-inflammatory effect. Curcumin loaded…
Formulation and characterization of curcumin nanoparticles for skin cancer treatment
Curcumin possesses remarkable chemotherapeutic activity owing to its anti-inflammatory and anti-oxidant properties. Purpose of the research work was to prepare curcumin-loaded nanoparticles of Eudragit E 100 for topical skin applications…
Is Oral Lipid-Based Delivery for Drug Targeting to the Brain Feasible?
This review outlines the feasibility of oral lipid-based targeted delivery of drugs to the brain, including permeation of the central nervous system’s (CNS) protective blood-brain barrier (BBB). The structure of the BBB and disruption…
Hydroxypropyl-β-Cyclodextrin Enhances Oral Absorption of Silymarin Nanoparticles Prepared Using…
The oral bioavailability of drugs is limited by factors such as poor membrane permeability, low solubility, and low dissolution rate. Silymarin (SLM) is a health-food active ingredient that is good for immunosuppression and tumor…
Improving Process Understanding in Roll Compaction
Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further…
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics
The world raced to develop vaccines to protect against the rapid spread of SARS-CoV-2 infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of candidates was evaluated, with mRNA-based vaccines emerging as…
A review on recent advances in nanomedicines for the treatment of pulmonary tuberculosis
Tuberculosis (TB) has been the most life-threatening contagious disease caused by pathogenic mycobacterium tuberculosis. The World Health Organization (WHO) report, 2020 estimated that this highly burden bacterial infection becomes the…
Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient
Diseases affecting the anterior segment and the external surface of the eye are usually treated by drugs applied topically. The formulations designed for this purpose are developed to deliver active pharmaceutical agents to the eye…