Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were…
Webinar: Pellets from fluid bed processes – a smart concept for high(er) potent drug processing
Manufacturing tablets is frequently a multi-step process: weighing, granulation, milling, blending, compression, coating. The efforts to provide a safe work environment for the production staff are considerably reduced when a technology…
Formulating for the Future: Oral Drug Delivery for Improving Bioavailability & Patient Outcomes
Oral drug administration is critical for the delivery of drugs in various therapeutic areas, such as cardiovascular and pain management. It is considered the preferred route of administration due to its significant advantages, including…
Nanostructured Lipid Carrier: A Potential System for Enhanced Oral Bioavailability of Felodipine
Background: Felodipine is BCS class II drug with poor and variable bioavailability due to its insolubility in water (19mg/L) and extensive metabolism in liver and gut. Thus, in the study Nanostructured lipid carriers (NLCs) of Felodipine…
Self-emulsification in chemical and pharmaceutical technologies
The interest in the low energy self-emulsification techniques has exploded in the recent years, driven by three main trends: by the transition to “greener” technologies in both its aspects – less energy consumption and replacement of the…
Prediction of the impact of lubrication on tablet compactibility
The tableting of most pharmaceutical formulations requires the addition of lubricants to reduce ejection forces, prevent tooling damage and tablet defects. The internal addition of lubricants is known to reduce tablet tensile strength,…
Webinar: What can you expect as a participant at ExciPerience?
ExciPerience - the online event around excipients and new trends in pharmaceutical technology!
But what exactly is the ExciPerience? Who are the speakers and what are the main topics? Why should I participate in this event and what will I…
Eudragit® L100/chitosan composite thin bilayer films for intravaginal pH-responsive release of…
The high rate of HIV new infections and AIDS-related deaths each year make prevention tools still necessary today. Different dosage forms – including films – for vaginal administration of antiretroviral drugs have been developed for this…
What’s next in the use of opacifiers for cosmetic coatings of solid dosage forms? Insights on…
The consolidated use of coatings containing E171 (i.e. titanium dioxide, TiO2) as an opacifier has made the white color of the resulting dosage forms a quality standard in the pharmaceutical and dietary supplement fields. This color is also…
3D printing of pharmaceutical oral solid dosage forms by fused deposition: the enhancement of…
3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing printability by improving feedability, nozzle extrusion, and layer deposition is crucial for…
Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive…
Purpose
Industrial implementation of continuous oral solid dosage form manufacturing has been impeded by the poor powder flow properties of many active pharmaceutical ingredients (APIs). Microfluidic droplet-based particle synthesis is an…
Dose-independent Drug Release from 3D Printed Oral Medicines for Patient-specific Dosing to Improve…
Fused deposition modelling (FDM) 3D printing provides the ability to address individual patients’ therapeutic needs without having to change the formulation every time. This is particularly interesting for dosing and release modelling. In…
Use of Two-Factor Dispersion Analysis for Studying the Pharmaceutical and Technological Properties…
The influence of the type and ratio of co-process fillers and lubricating excipients on the properties of the final dosage form was studied during the development of the composition and technology for GK-2 tablets dispersed in the oral…
Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior…
A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal…
Revealing the roles of polymers in supersaturation stabilization from the perspective of…
Formulating drugs into amorphous solid dispersions (ASDs) represents an attractive means to enhance the aqueous solubility of drugs. Furthermore, water-soluble polymers have proven highly advantageous for stabilizing supersaturated…
DuPont Site In Newark, Delaware, USA Receives EXCiPACT GMP Certification As Pharmaceutical Excipient…
Brussels, 04 February 2022
EXCiPACT is pleased to announce that the DuPont Nutrition USA, Inc. site in Newark, Delaware, USA has recently been awarded an EXCiPACT GMP Certificate from SGS, one of EXCIPACT’s internationally recognised…
Moisture sorption by polymeric excipients commonly used in amorphous solid dispersion and its effect…
Moisture plays a critical role in the stability of amorphous solid dispersions (ASD) as it can lower the glass transition temperature (Tg) and thereby increase molecular mobility resulting in drug crystallization. A systematic study on…
Oxidation of Drugs during Drug Product Development: Problems and Solutions
Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is…
FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with…
The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different shapes (cylinder, capsule and hemisphere) and infill percentages (0% and 15%), and to…
Confining the growth of mesoporous silica films into nanospaces: towards surface nanopatterning
The combination of lithographic methods and sol gel bottom-up techniques is a promising approach for nanopatterning substrates. The integration and scalable fabrication of such substrates are of great interest for the development of…
QbD Approach towards Robust Design Space for Flutamide/Piperine Self-Emulsifying Drug Delivery…
Flutamide which is used to treat prostate cancer and other diseases induces liver damage during and after the therapy. The aim of this study was to develop a flutamide/piperineco-loaded self-emulsifying drug delivery system (FPSEDDS) to…
Design and Characterization of Lipid Nanocarriers for Oral Delivery of Immunotherapeutic Peptides
The use of therapeutic proteins and peptides is of great interest for the treatment of many diseases, and advances in nanotechnology offer a path toward their stable delivery via preferred routes of administration. In this study, we sought…
Taking leads out of nature, can nano deliver us from COVID-like pandemics?
The COVID-19 crisis has alerted the research community to re-purpose scientific tools that can effectively manage emergency pandemic situations. Researchers were never so desperate to discover a 'magic bullet' that has significant clinical…
Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors
The use of chemotherapeutic agents such as docetaxel (DTX) in anticancer therapy is often correlated to side effects and the occurrence of drug resistance, which substantially impair the efficacy of the drug. Here, we demonstrate that…
Eudragit coated microemulsion for enhanced efficacy of spiramycin against toxoplasmic encephalitis
The study investigated Eudragit coated microemulsion (ME) for oral delivery of spiramycin in treatment of toxoplasmic encephalitis. The goal was to augment the efficacy of ME by protection from gastrointestinal conditions and/or providing…
ROQUETTE’S LYCAGEL® OFFERING JUST GOT BIGGER
Roquette’s NEW premix solution for veggie softgel formulation is here – a ready-to-use, plant-based blend for nutraceutical AND pharmaceutical softgel formulations. LYCAGEL® Premix is easily incorporated into existing manufacturing…
PCL-PEG copolymer based injectable thermosensitive hydrogels
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and…
JRS PHARMA Announces Launch of New TiO2-Free Tablet Coating VIVACOAT® free
Holzmühle, Germany | February 2022 - JRS PHARMA proudly introduces the solution for Titanium Dioxide free ready-to-use coatings, VIVACOAT® free.
In early 2022, Titanium Dioxide will be banned as a food additive in the EU, with…
Eudragit coated microemulsion for enhanced efficacy of spiramycin against toxoplasmic encephalitis
The study investigated Eudragit coated microemulsion (ME) for oral delivery of spiramycin in treatment of toxoplasmic encephalitis. The goal was to augment the efficacy of ME by protection from gastrointestinal conditions and/or…
Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German…
Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics,…
Paediatric specific dosage forms: Patient and formulation considerations
The total number of paediatric formulations available only account for a small proportion of the full therapeutic plethora required to effectively treat paediatrics and, therefore, the availability of high quality medicines designed…
A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
A properly designed nanosystem aims to deliver an optimized concentration of the active pharmaceutical ingredient (API) at the site of action, resulting in a therapeutic response with reduced adverse effects. Due to the vast availability of…
In Vitro and In Vivo Studies of a Verapamil-Containing Gastroretentive Solid Foam Capsule
Gastroretentive systems may overcome problems associated with incomplete drug absorption by localized release of the API in the stomach. Low-density drug delivery systems can float in the gastric content and improve the bioavailability of…
Use of titanium dioxide in medicinal products – Swissmedic announcement January 1, 2022
The pharmaceutical excipient titanium dioxide remains permissible in Switzerland until further notice
In October 2021, the EU Member States approved the proposal of the European Commission to ban titanium dioxide in all food products in…
Biological fate and interaction with cytochromes P450 of the nanocarrier material, D-α-tocopheryl…
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol (PEG) 1000. It is approved by the US Food and…