Development and Evaluation of Solidified Supersaturated SNEDDS Loaded with Triple Combination Therapy for Metabolic Syndrome
The present study aimed to develop and optimize solidified supersaturated self-nanoemulsifying drug delivery systems (SNEDDS) for the combined administration of antihypertensive, antihyperglycemic, and antihyperlipidemic drugs to enhance their solubility and dissolution during the treatment of metabolic syndrome. Various SNEDDS formulations were…
Factors Influencing the Crystallization-Onset Time of Metastable ASDs
In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the crystallization of APIs often limits long-term…
Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release…
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative…
Transdermal formulations and strategies for the treatment of osteoporosis
Osteoporosis is a silent and growing disease that constitutes a major health issue, due to its association with an elevated risk of fractures, morbidity, mortality, and re-hospitalization, along with the big financial burden involved. Drugs…
Solid Dispersion of Artemether in Fast Disintegrating Tablet to Enhance Dissolution Rate and Oral…
Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus (SOL) and was incorporated in the fast disintegrating tablet.…
Fabrication of delayed release hard capsule shells from zein/methacrylic acid copolymer blends
Hard capsule shells with an inherent delayed release action are useful for oral administration of active ingredients, which are acid-labile and/or enzymatically degradable in the gastric environment, without the need of film coating. The…
Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into…
Micromechanical analysis of roller compaction process with DEM
This study applies the discrete element method (DEM) to the roller compaction process for the analysis of particle flow behavior, porosity distribution in the compaction zone and in the final ribbon, as well as the pressure distribution on…
Current trends in drug delivery and excipients in the pharmaceutical industry
An outlook on the importance of excipients by pharmaexcipients which will also be part of the upcoming ExciPerience Event - March 9 & 10, 2022
Excipients play a crucial role to achieve a drug product and drug delivery profile. With the…
Micelles based on polyvinylpyrrolidone VA64: A potential nanoplatform for the ocular delivery of…
Purpose of this work was to determine the feasibility of a nano-ophthalmic solution consisting of the nanocarrier polyvinylpyrrolidone VA64 (VA64) and encapsulated apocynin (APO) as treatment for ocular inflammatory diseases. Results showed…
Introducing novel hybridization technique for solubility enhancement of Bosentan formulation
Bosentan is choice of drug for pulmonary arterial hypertension. It belongs to BCS class-II category. Due to poor solubility in aqueous media, treatment leads to frequent dosing & increasing cost of therapy subsequently. One cannot…
Solid Dispersion of Lumefantrine Using Soluplus® by Solvent Evaporation Method: Formulation,…
Objectives: Lumefantrine (LUM) is an antimalarial drug having poor aqueous solubility. The objective was to formulate the solid dispersion of LUM and improve the solubility and dissolution rate.
Materials and Methods: Solvent evaporation…
Construction of calcium carbonate-liposome dual-film coated mesoporous silica as a delayed drug…
As is well known to all, delivering drug precisely to the tumor site is beneficial to improve the antitumor effect. In this study, we reported mesoporous silica nanoparticles (MSNs) coated with dual-film of calcium carbonate (CaCO3) and…
Design and molecular insights of drug-active metabolite based co-amorphous formulation: A case study…
Co-amorphous supersaturated drug delivery systems are emerging as an alternative strategy to improve the water solubility of BCS II drugs. Typically, the supersaturation and stability of co-amorphous systems largely depend on the type of…
Mechanistic understanding of metal-catalyzed oxidation of polysorbate 80 and monoclonal antibody in…
Surfactants are commonly used in biotherapeutic formulations to prevent the formation of aggregates and protect proteins from denaturation. Among them polysorbates are the most widely used. However, they are known to be prone to…
CEOLUS™ – Innovative Tableting Solutions by Asahi Kasei
Asahi Kasei's pharmaceutical excipients CEOLUS™ offers a wide range of solutions to many problems facing the industry, including:
Significant Tablet Size Reduction
The high compactibility of Ceolus™ UF-711 allows for sufficient hardness…
The Effect of Polymers on Drug Release Kinetics in Nanoemulsion In Situ Gel Formulation
Glaucoma is an ocular condition characterized by elevated intraocular pressure (IOP). Conventional treatments of glaucoma face poor corneal permeability and bioavailability. To address these issues, a nanoemulsion in situ gel of Timolol…
Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods
An increasing proportion of new medicinal substances are poorly soluble in water. Adsorption on mesoporous silicas increases their bioavailability when administered orally. Loading method determines adsorption either on the surface in…
Role of Cyclodextrins and Drug Solid State Properties on Flufenamic Acid Dissolution Performance…
Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug characterised by a low solubility and problems of variable dissolution rate and bio-inequivalence. Different FFA batches, obtained by different suppliers, showed different…
A Novel Multilayer Natural Coating for Fed-State Gastric Protection
Several nutraceutical products require gastric protection against the hostile environment in the stomach. Currently marketed synthetic and semi-synthetic coatings suffer from major shortcomings such as poor gastric protection, slow-release…
Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in…
The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line. As all mixture components, including the lubricant…
Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique
Pharmaceutical tablets can be produced on different kinds of presses that may have very different compaction kinematics. Strain rate sensitivity (SRS) is thus an important property for the powders used to produce pharmaceutical tablets.…
Sampling and diversion strategy for twin-screw granulation lines using batch statistical process…
Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects the complexity to translate a science that has been described in many…
Design-of-experiment approach to quantify the effect of nano-sized silica on tableting properties of…
There are challenges to implementing high-speed direct compression tableting for poor flow, low-density cohesive powder. Thus, excipients with adequate flowability and bulk density are desired to facilitate this process. As a major novelty,…
Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible…
Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient mechanical stability. In order to meet these and other critical…
Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying…
The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole for the treatment of Parkinson’s disease. The active pharmaceutical ingredient (API) and one of the polymers…
Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and…
Nanocapsules can be equated to other nanovesicular systems in which a drug is entrapped in a void containing liquid core surrounded by a coat. The objective of the present study was to investigate the potential of polymeric and lipid…
Multifunctional Cellular Targeting, Molecular Delivery, and Imaging by Integrated Mesoporous-Silica…
Multifunctional nanoprobes have attracted significant attention in a wide range of disciplines such as nanomedicine, precision medicine, and cancer diagnosis and treatment. However, integrating multifunctional ability in a nanoscale…
Drug delivery to the intestinal lymph by oral formulations
Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases. The intestinal lymph harbors numerous lymphocyte subsets, and DDS containing lipids such as…
GRANFILLER-D™ Water Absorption Behavior and Disintegration Mechanism
In the formulation design of conventional orally disintegrating tablets (ODTs) by direct compression, disintegratablity often reduces when active pharmaceutical ingredient (API) content is high. Since API tends to block the gap between…
Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions
Disintegration and dispersion are functional properties of tablets relevant for the desired API release. The standard disintegration test (SDT) described in different pharmacopoeias provides only limited information on these complex…
Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics
In the treatment of pediatric diseases, mass-produced dosage forms are often not suitable for children. Commercially available medicines are commonly manipulated and mixed with food by caregivers at home, or extemporaneous medications are…
Nestorone nanosuspension-loaded dissolving microneedles array patch: A promising novel approach for…
“On demand” hormonal female-controlled pericoital contraception is one strategy which could be used to minimize the impact of unintended pregnancy. Nestorone (NES) is a potent contraceptive, with relatively few side effects in comparison…
Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions:…
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid dispersions. The present study investigates the impact of binary and ternary amorphous…
Progress in the transdermal delivery of antimigraine drugs
Most antimigraine drugs are taken orally but the oral route of drug administration has several limitations including pre-systemic metabolism which leads to low bioavailability. Transdermal route provides an alternative method of drug…