Hot melt extruded High-Dose amorphous solid dispersions containing lumefantrine and Soluplus
Abstract
Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet® and Coartem® dispersible tablets, a combination of artemether and lumefantrine, co-developed by the Medicines for Malaria Venture and Novartis. Disappointingly, patient compliance, requirement for…
The Hitchhiker’s Guide to Human Therapeutic Nanoparticle Development
Nanomedicine plays an essential role in developing new therapies through novel drug delivery systems, diagnostic and imaging systems, vaccine development, antibacterial tools, and high-throughput screening. One of the most promising drug…
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency
The efficacy of RNA-based vaccines has been recently demonstrated, leading to the use of mRNA-based COVID-19 vaccines. The application of self-amplifying mRNA within these formulations may offer further enhancement to these vaccines, as…
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate…
The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other…
Relationship between powder properties and uniformity of ribbon property using feeding guider…
Roller compaction is a continuous dry granulation process in which two counter-rotating rollers compress the powder. The feeding of powder to the compaction zone has a significant effect on product quality in the process. This work aims to…
Effect of Magnesium Stearate Surface Coating Method on the Aerosol Performance and Permeability of…
In this study, we evaluated the aerodynamic performance, dissolution, and permeation behavior of micronized fluticasone propionate (FP) and magnesium stearate (MgSt) binary mixtures. Micronized FP was dry mixed with 2% w/w MgSt using a…
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Physico-chemical analysis of electrospun fibers – A systematic approach
Electrospun fibers emerged as promising drug delivery systems for various pharmaceutical applications due to their favorable properties. However, while for established drug delivery systems (e.g. tablets or capsules) standardized analytical…
Pharmaceutical nanotechnology: from the bench to the market
Background
Nanotechnology is considered a new and rapidly emerging area in the pharmaceutical and medicinal field. Nanoparticles, as drug delivery systems, impart several advantages concerning improved efficacy as well as reduced adverse…
Nanostructured Lipid Carriers Loaded with Lippia sidoides Essential Oil as a Strategy to Combat the…
The emerging pathogen Candida auris is an emerging fungal pathogen that was associated with nosocomial infectious outbreaks. Its worldwide incidence and the emerging multidrug-resistant strains highlight the urgency for novel and effective…
Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory…
The in vivo ability of thermosensitive nanogel containing ibuprofen for bioadhesion on the surface of teeth submitted to bleaching and drug delivery through dentinal tubules to the dental pulp are evaluated in Wistar rats. Drug-loaded…
Mechanism of interaction between hydroxypropyl cellulose and water in aqueous solutions: Importance…
The utilization of hydroxypropyl cellulose (HPC) can be regarded as unexpected with regard to certain applications, such as being employed as a solubility enhancer for poorly soluble drugs and as a solubilizing agent for nano-suspensions…
Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children
The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of…
Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic…
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of…
Trilayer microneedle array assisted transdermal and intradermal delivery of dexamethasone
Dexamethasone is a synthesised glucocorticoid that is widely used in the treatment of various inflammatory skin conditions. Novel trilayer dissolving microneedle arrays were manufactured to assist dexamethasone delivery via the skin. Both …
In-Depth Understanding of Granule Compression Behavior under Variable Raw Material and Processing…
Tablet manufacturing involves the processing of raw materials through several unit operations. Thus, the mitigation of input-induced variability should also consider the downstream processability of intermediary products. The objective of…
Gum-based nanocapsules comprising naphthoquinones enhance the apoptotic and trypanocidal activity…
Nanoencapsulation is a promising approach to enhance the therapeutic potential of a drug. Herein, three selected naphthoquinone (NTQ) derivatives, based on the IC50 value against Trypanosoma evansi, were encapsulated using gum damar as…
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass…
ExciPerience – Early Bird sale ends on January 31st
ExciPerience is the virtual event around every aspect of pharmaceutical excipients. ExciPerience covers all areas from basic or advanced research and formulation to manufacturing and regulatory. There will be more and new possibilities for…
Pharmeuropa 34.1 just released
All new European Pharmacopoeia (Ph. Eur.) texts and texts that have undergone technical revisions are published in Pharmeuropa for public consultation. The deadline for comments on Pharmeuropa 34.1 is 31 March 2022.
Users and interested…
The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous…
Current study investigated the effect of different binder types on the granule drying process and the granule breakage behavior in a semi-continuous fluid bed dryer integrated in the C25 ConsiGma-system. The studied binders (i.e.…
Novel Bilayer Microarray Patch-Assisted Long-Acting Micro-Depot Cabotegravir Intradermal Delivery…
Injectable long-acting cabotegravir (CAB LA) is effective and safe for pre-exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained…
In-depth analysis of the long-term processability of materials during continuous feeding
This study determined the feasibility of long-term continuous powder feeding and its effect on the overall process performance. Additionally, quantitative relationships were established between material properties, process settings and…
Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory…
The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; however, its poor water solubility limits its use. Amorphous solid dispersions may overcome this challenge, but…
100% visual inspection of tablets produced with continuous direct compression and coating
Visual appearance of tablets is an important property for patients. Since the visual appearance is most strongly influenced by the applied coating, this necessitates a high level of process control and homogeneity in the coating process. In…
Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct…
While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet manufacturing, in continuous operation, it is an important additional critical process…
Towards Virtual Bioequivalence Studies for Oral Dosage Forms Containing Poorly Water-Soluble Drugs:…
The objective of the present study was to develop a physiologically based biopharmaceutics (PBBM) approach to predict the bioequivalence of dosage forms containing poorly soluble drugs. Aripiprazole and enzalutamide were used as model…
Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable…
In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery…
Evaluation of the Mucoadhesive Properties of Chitosan-Based Microstructured Lipid Carrier (CH-MLC)
Different mucoadhesive systems have been studied in recent years to increase the residence time of the delivery systems and to prolong the release of the drug. The aim of this work was to evaluate the mucoadhesive properties of…
Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Functionalized Lipid…
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the…
Management and control of intraocular pressure applying macitentan hydrogel film formulation:…
Background
Macitentan blocks endothelin receptors in order to control the pulmonary arterial hypertension (PAH). Oral administration of macitentan is associated with painful urination and troubled breathing.
Objectives
Formulated…
Nitrosamines Risk Assessments for excipients available now in RegXcellence™
What are nitrosamines?
Nitrosamines are chemical compounds that can be formed from secondary amines with a nitrosating agent. Those nitrosating agents can be nitrous acid, nitrites or NOX. Nitrosamines may be found in drinking water and…
Influence of commonly used excipients on the chemical degradation of enalapril maleate in its solid…
The physicochemical stability of enalapril maleate was investigated in the presence of fourteen different excipients divided into four different classes. The extent of a drug-excipient interaction was investigated by following the chemical…
The effect of screw configuration and formulation variables on liquid requirements and granule…
The effect of two screw configurations with varying stagger angle was evaluated on the liquid amount required to produce good quality granules for a highly (mannitol-based) and a poorly (DCP-based) soluble formulation containing different…