Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for…
A bioequivalence study comparing two fixed dose combination tablets containing 200 mg ibuprofen and 30 mg pseudoephedrine hydrochloride showed bioequivalence for pseudoephedrine AUC and Cmax, but the reference product showed higher Cmax …
Investigating key properties of model excipients and binary powder blends using ultrasonic in-die…
In this work, the recently introduced Kilian Inline Measurement System (KIM) that enables ultrasonic measurements during powder compaction was studied using three pharmaceutical excipients with different properties and particle sizes,…
Evonik – Now also a global CDMO for lipid nanoparticles
INTEGRATED CDMO SERVICES FOR LIPID-NANOPARTICLE-BASED GENETIC DRUGS AND OTHER NANOMEDICINES SINCE THE 1990S
Evonik Vancouver Laboratories, formerly known as Transferra Nanosciences Inc. or Northern Lipids, has been a market CDMO leader for…
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers
The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers…
Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1…
GSK2982772 is a selective inhibitor of receptor-interacting protein kinase-1, with a 2–3 h half-life. This study evaluated if a once-daily modified-release formulation of GSK2982772 could be developed with no significant food effect.…
Development and evaluation of nano-formulations for immediate release oral dosage forms of poorly…
Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Zun Huang
Solubility and dissolution rate are…
Advancing pharmacy and healthcare with virtual digital technologies
Digitalisation of the healthcare sector promises to revolutionise patient healthcare globally. From the different technologies, cyber tools including artificial intelligence, blockchain, virtual, and augmented reality, to name but a few,…
Apinovex™ Polymers – the Key to Addressing Solubility Challenges in Oral Formulations
Between 40-70% of marketed drugs and up to 90% of all new chemical entities (NCEs) suffer from poor water solubility, meaning they don’t readily dissolve in an aqueous solution. This has significant negative consequences for the…
2021 FDA approvals
The FDA approved 50 novel drugs in 2021, including the first KRAS inhibitor for cancer and the first anti-amyloid antibody for Alzheimer’s disease.
Article by Asher Mullard - Nature Reviews Drug Discovery - 04 January 2022
The FDA’s…
Excipient Innovation Through Precompetitive Research
The mRNA COVID-19 vaccines developed by Pfizer/BioNTech and Moderna represent a triumph of vaccine development. The core mRNA component of these vaccines is now almost a household name. Unbeknownst to most people, however, is that each of…
Lipid-based nanocarriers for oral delivery of peptides
Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the…
Reality augmented by Gattefossé
Augmented reality in oral bioavailability enhancement arena:
Labrafac™ MC60, glycerol monocaprylocaprate
Gattefossé widens its range of high quality, functional excipients for oral bioavailability enhancement with Labrafac™ MC60,…
Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid…
Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification method and optimized statistically by…
Electrospun poly(ω-pentadecalactone-co-ε-caprolactone)/gelatin/chitosan ternary nanofibers with…
In recent years, there is an increasing attention on biocompatible electrospun nanofibers for drug delivery applications since they provide high surface area, controlled and sustained drug release, and they mimic the extracellular matrix.…
Revolutionary benchtop R&D tablet press STYL’One Nano
The STYL’One Nano by MEDELPHARM is the revolutionary benchtop R&D tablet press for demanding formulation scientists with price performance in mind. Characterize your API and develop your single layer formulation with only a few grams of…
Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets
Additive manufacturing technologies are considered as a potential way to support individualized pharmacotherapy due to the possibility of the production of small batches of customized tablets characterized by complex structures. We designed…
Evaluation of Excipient Risk in BCS Class I and III Biowaivers
The objective of this review article is to summarize literature data pertinent to potential excipient effects on intestinal drug permeability and transit. Despite the use of excipients in drug products for decades, considerable research…
Definitive Agreement to Acquire Exelead will Strengthen Merck’s CDMO Offering for mRNA
Merck has signed a definitive agreement to acquire Exelead, a biopharmaceutical contract development and manufacturing organization (CDMO), for approximately USD 780 million in cash.
Targeted acquisition to accelerate novel…
Mechanistic insight into gel-induced aggregation of amorphous curcumin during dissolution process
Amorphous curcumin (CUR) exhibited a decreased dissolution rate in comparison with the crystalline counterpart due to its gel formation during dissolution. The main purpose of the present study is to explore the mechanism of such gelation…
Advances in the Treatment of Inflammatory Bowel Disease: Focus on Polysaccharide Nanoparticulate…
The complex pathogenesis of inflammatory bowel disease (IBD) explains the many hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to reduce inflammation during the hot phase or maintain remission…
Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of…
Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that…
Lipid Nanoparticles for the Posterior Eye Segment
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye…
Sodium alginate as a pharmaceutical excipient: novel applications of a well-known polymer
Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important…
Application of a novel electrostatic dry powder coating technology on capsules for enteric release
Dry coating of pharmaceutical dosages represents the future of functional coating given its environmental friendliness and cost effectiveness. Based on the electrostatic dry powder coating technology developed by our group, hard gelatin…
Impact of Powder Properties on the Rheological Behavior of Excipients
With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization…
Streamlining tablet lubrication design via model-based design of experiments
In oral solid dosage production through direct compression powder lubrication must be carefully selected to facilitate the manufacturing of tablets without degrading product manufacturability and quality (e.g. dissolution). To do so,…
Effect of Soluplus® on γ-cyclodextrin solubilization of irbesartan and candesartan and their…
The poor aqueous solubility of irbesartan (IRB) and candesartan cilexetil (CAC) may hamper their bioavailability when orally or topically administered. Among several attempts, the promising nanoaggregate formation by γ-cyclodextrin (γCD)…
Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures
The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing…
A systematic approach for assessing the suitability of enteral feeding tubes for the administration…
Enteral nutrition plays an important role for patients who are unable to properly swallow food. In such patients, enteral feeding tubes are often used, through which food, but often also oral medications, are administered. However, this can…
Ball milling and hot-melt extrusion of indomethacin–L-arginine–vinylpyrrolidone-vinyl acetate…
Commonly applied approaches to enhance the dissolution properties of low water-soluble crystalline active pharmaceutical ingredients (APIs) include their amorphization by incorporation into a polymeric matrix and the formation of amorphous…
3D printed medicine for the management of Chronic Diseases: The road less travelled
The management of every disease is cumbersome and considered a significant burden, but the treatment of chronic diseases is more arduous than any other disease process. These diseases often demands a long-term pharmacotherapy, drug and…
A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for…
Chemotherapy is almost exclusively administered via the intravenous (IV) route, which has serious limitations (e.g., patient discomfort, long hospital stays, need for trained staff, high cost, catheter failures, infections). Therefore, the…
Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden:…
Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this study, we investigated drug…
Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt…
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in…