PLGA Nanoparticles Based Mucoadhesive Nasal In Situ Gel for Enhanced Brain Delivery of Topiramate
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,abdominal pain, and fluctuations in plasma levels. The purpose of this research was to develop an intranasal in situ gel based system comprising Topiramate polymeric nanoparticles and evaluate its potential both in vitro and in vivo. Poly (lactic-co-glycolic…
3D printed medicine for the management of Chronic Diseases: The road less travelled
The management of every disease is cumbersome and considered a significant burden, but the treatment of chronic diseases is more arduous than any other disease process. These diseases often demands a long-term pharmacotherapy, drug and…
A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for…
Chemotherapy is almost exclusively administered via the intravenous (IV) route, which has serious limitations (e.g., patient discomfort, long hospital stays, need for trained staff, high cost, catheter failures, infections). Therefore, the…
Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden:…
Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this study, we investigated drug…
Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt…
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in…
Smart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review
Cancer is a group of disorders characterized by uncontrolled cell growth that affects around 11 million people each year globally. Nanocarrier-based systems are extensively used in cancer imaging, diagnostics as well as therapeutics; owing…
Solvent-Free Fabrication of Biphasic Lipid-Based Microparticles with Tunable Structure
Lipid-based biphasic microparticles are generally produced by long and complex techniques based on double emulsions. In this study, spray congealing was used as a solvent-free fabrication method with improved processability to transform…
Recent Trends in Assessment of Cellulose Derivatives in Designing Novel and Nanoparticulate-Based…
Natural polymers are revolutionizing current pharmaceutical dosage forms design as excipient and gained huge importance because of significant influence in formulation development and drug delivery. Oral health refers to the health of the…
A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery…
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic…
Surfactant Protection Efficacy at Surfaces Varies with the Nature of Hydrophobic Materials
Objective
Monoclonal antibodies are in contact with many different materials throughout their life cycle from production to patient administration. Plastic surfaces are commonly found in single use bags, syringes, perfusion bags and tubing…
Exploring the potential of oleic acid in nanotechnology-mediated dermal drug delivery: An up-to-date…
Oleic acid (OA), the naturally occurring fatty acid, is a multifunctional pharmaceutical excipient with penetration enhancing property for effective skin applications. Topical drug delivery via nano-carriers is also a widely used approach…
Evolution of drug delivery systems: From 1950 to 2020 and beyond
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-release capsule technology, which can deliver a drug for 12 h after oral administration through an initial immediate dose followed by the remaining…
Transformation of nanoparticles into compacts: A study on PLGA and celecoxib nanoparticles
Oral delivery of nanoparticles possesses many advantages for delivery of active pharmaceutical ingredients (APIs) to the gastrointestinal tract. However, the poor physical stability of nanoparticles in liquid state is often a challenge.…
Effect of micro- and nanoparticle shape on biological processes
In the drug delivery field, there is beyond doubt that the shape of micro- and nanoparticles (M&NPs) critically affects their biological fate. Herein, following an introduction describing recent technological advances for designing…
Fabrication Methods and Form Factors of Gellan Gum-Based Materials for Drug Delivery and Anti-Cancer…
Despite the success of cancer therapeutics, off target cell toxicity prevails as one of the main challenges of cancer treatment. Exploration of drug delivery methods is a growing field of research, which involves a variety of materials and…
Quantitative analysis of blend uniformity within a Three-Chamber feed frame using simultaneously…
This study reports the use of Raman and Near-infrared (NIR) spectroscopy to simultaneously monitor the drug concentration in flowing powder blends within a three-chamber feed frame. The Raman probe was located at the top of the dosing…
Impact of blend properties and process variables on the blending performance
In this study, quantitative relationships were established between blend properties, process settings and blending responses via multivariate data-analysis. Four divergent binary blends were composed in three different ratios and processed…
Best practices in current models mimicking drug permeability in the gastrointestinal tract –…
The absorption of orally administered drug products is a complex, dynamic process, dependent on a range of biopharmaceutical properties; notably the aqueous solubility of a molecule, stability within the gastrointestinal tract (GIT) and…
Eudragit S100 prepared pH-responsive liposomes-loaded betulinic acid against colorectal cancer in…
This study aimed to develop polymer Eudragit S100 for preparing pH-responsive liposomes-loaded betulinic acid (pH-BA-LP) to improve the therapeutic index of chemotherapy for colorectal cancer. BA-loaded liposomes were coated with Eudragit…
Streamlining the development of an industrial dry granulation process for an immediate release…
In industrial practice, the development of pharmaceutical dry granulation processes typically involves time- and resource-intensive multivariate experiments. These experiments are used to identify the set of operating conditions, their…
Wet powder rheometry: The best conditions for wet granulation using diluent and binder in calcium…
Calcium is an important component for bone maintenance and osteoporosis prevention and can be found in tablet dosage form for dietary supplementation. However, as it contains a high amount of elemental calcium (Ca ++ 500 mg), the production…
Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered…
Despite much progress in regulations to improve paediatric drug development, there remains a significant need to develop better medications for children. For the design of oral dosage forms, a detailed understanding of the specific…
Continuous direct compression: Development of an empirical predictive model and challenges regarding…
In this study, an empirical predictive model was developed based on the quantitative relationships between blend properties, critical quality attributes (CQA) and critical process parameters (CPP) related to blending and tableting. The…
Zein-Based Nanoparticles as Oral Carriers for Insulin Delivery
Zein, the major storage protein from corn, has a GRAS (Generally Regarded as Safe) status and may be easily transformed into nanoparticles, offering significant payloads for protein materials without affecting their stability. In this work,…
Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport
Challenges to effective delivery of drugs following oral administration has attracted growing interest over recent decades. Small molecule drugs (<1000 Da) are generally absorbed across the gastrointestinal tract into the portal blood…
PAT implementation for advanced process control in solid dosage manufacturing – A practical guide
The implementation of continuous pharmaceutical manufacturing requires advanced control strategies rather than traditional end product testing or an operation within a small range of controlled parameters. A high level of automation based…
Development and analysis of a novel loading technique for FDM 3D printed systems: Microwave-assisted…
In this paper, we describe a modular post-printing loading protocol for a 3D printed gastro-retentive drug delivery system. Fused Deposition Modelling (FDM) 3D printing was exploited for the rapid prototyping of a modular floating system…
Insight into tableted pellets by combining X-ray micro-computed tomography and experimental…
Pellets are spherical agglomerated particles used to produce multiparticulate pharmaceutical dosage forms. This study aims to develop a new approach that evaluates the deformation behavior of pellets under compression, by combining…
Chitosan/cyclodextrin surface-adsorbed naringenin-loaded nanocapsules enhance bacterial quorum…
Pathogenic bacteria use quorum sensing (QS), a cell-to-cell communication process that uses small signalling molecules, to regulate several essential virulence factors such as bioluminescence, biofilm formation, and bacterial motility.…
Optimization of diluents on the basis of SeDeM-ODT expert system for formulation development of ODTs…
The present study aimed to optimize diluents characteristics (rheological characteristics, compressibility and disintegration behavior) using SeDeM-ODT expert system, to mask poor characteristics of APIs and will help in development of a…
Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against…
Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence of 1.3 million new cases annually. The conventional therapy for visceral leishmaniasis requires hospitalization due to the severe adverse effects…
Relative bioavailability enhancement of simvastatin via dry emulsion systems: comparison of spray…
Comprehensive comparisons of similar lipid based drug delivery systems produced by different technologies are scarce. Spray drying and fluid bed layering technologies were compared with respect to the process and product characteristics of…
Breaking patterns of press-coated tablets during the diametral compression test: Influence of the…
Press-coated tablets are a high-interest technology in chronopharmaceutics, for modified release applications. As for any kind of tablet, the test of the mechanical resistance is of primary importance at the industrial level during both the…
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and…
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is unclear, which viral replication steps can be efficiently inhibited with siRNAs. Here, we…
Some attempts to increase the amount of drug coated onto the microneedles
As an approach of painless administration, coated microneedles (MNs) system has increased attention on the drug loading capacity to meet higher drug dosage requirements. In this work, the solid and coated MNs were successfully fabricated…