PLGA Nanoparticles Based Mucoadhesive Nasal In Situ Gel for Enhanced Brain Delivery of Topiramate
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,abdominal pain, and fluctuations in plasma levels. The purpose of this research was to develop an intranasal in situ gel based system comprising Topiramate polymeric nanoparticles and evaluate its potential both in vitro and in vivo. Poly (lactic-co-glycolic…
Orodispersible Films: A Delivery Platform for Solid Lipid Nanoparticles?
To overcome the poor bioavailability observed for many newly developed active pharmaceutical ingredients (APIs), an appropriate formulation strategy is necessary. One approach is the formulation of these substances in solid lipid…
Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of…
Spray-congealing (SPC) technology was utilized to prepare lipid-based microparticles (MP) capable of sustaining the release of Vildagliptin (VG) for use as a once-daily treatment for type 2 diabetes mellitus. VG microparticles were prepared…
Understanding the self-assembly of the polymeric drug solubilizer Soluplus®
Soluplus® is one of the most widely used amphiphilic copolymers in drug delivery and has been reported to strongly enhance the adsorption of model drugs. However, there is still a limited understanding of its micellar behavior as it…
Temperature and pH-responsive nanogels as intelligent drug delivery systems: A comprehensive review
With the advancement of technology and the evolution of modern healthcare systems, the focus is shifting from conventional drug delivery vehicles to novel, nanosized carriers. Nanogels are an example of such nanosized drug delivery systems…
Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing
Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression. This study aimed to improve tableting characteristics of lactose…
PharmaTher enters into Process Development Agreement with LTS for Ketamine Microneedle Patch
TORONTO/ANDERNACH, December 20, 2021 — PharmaTher Holdings Ltd. (“PharmaTher”) (OTCQB: PHRRF) (CSE: PHRM), a clinical-stage psychedelics biotech company, and LTS LOHMANN Therapie-Systeme AG (“LTS”), a leading pharmaceutical technology…
Impact of Swelling of Spray Dried Dispersions in Dissolution Media on Their Dissolution: An…
Impact of SDD-dissolution medium interactions on the swelling and dissolution of spray dried dispersions (SDDs) was investigated using UV imaging by monitoring SDD swelling in situ, along with correlating of the swelling with the…
Machine Learning and Machine Vision Accelerate 3D Printed Orodispersible Film Development
Orodispersible films (ODFs) are an attractive delivery system for a myriad of clinical applications and possess both large economical and clinical rewards. However, the manufacturing of ODFs does not adhere to contemporary paradigms of…
3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development,…
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the…
Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of…
High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different…
Pectin microparticles for peptide delivery: optimization of spray drying processing
Spray-dried pectin microparticles can potentially improve the oral bioavailability of peptides by virtue of their mucoadhesion. However, developing such formulations with desirable quality attributes is challenging due to the sensitivity of…
Asahi Kasei Contributes to Global Health Care by Supporting Increased Demand for Ceolus™…
NEW YORK--(BUSINESS WIRE)--Forecast expectations for increased global market demand in the excipients industry were confirmed at CPhI this past November where Asahi Kasei, a diversified Japanese multinational company, was met with warm…
Impact of polymer crosslinking on release mechanisms from long-acting levonorgestrel intrauterine…
Polydimethylsiloxane (PDMS) crosslinking density is a critical material attribute of levonorgestrel intrauterine systems (LNG-IUSs) that affects drug release and may have a significant influence on product performance and safety.…
Solubilization Strength Characterization of Parenteral Solutions Containing Polysorbate 80 in…
Leaching of chemical constituents from pharmaceutical polymeric contact materials to clinically relevant solutions including process streams, drug products, or body compartments, is a physicochemical process demanding expert analysis to…
Investigating key properties of model excipients and binary powder blends using ultrasonic in-die…
In this work, the recently introduced Kilian Inline Measurement System (KIM) that enables ultrasonic measurements during powder compaction was studied using three pharmaceutical excipients with different properties and particle sizes,…
Application of Dry Granulation to Facilitate Raw Material Handling
Pharmaceutical and biopharmaceutical manufacturing relies on the timely and seamless orchestration of many steps to meet aggressive timelines and ensure operational efficiency. A fundamental element of the processing workflow that can…
Food-grade olive oil Pickering emulsions stabilized by starch/β-cyclodextrin complex nanoparticles:…
The beneficial effects of olive oil consumption make it be one of the leading healthy edible oils worldwide. However, the water insolubility and oxidation of olive oil hinder its applications. In this study, food-grade oil-in-water olive…
Preparation and Functional Evaluation of Electrospun Polymeric Nanofibers as a New System for…
Due to the rapid clearance of external agents from the surface of the cornea, conventional ocular formulations usually require frequent and long duration of administration to achieve a therapeutic level of the drug on the cornea which can…
Fabrication of three-dimensional-printed ofloxacin gastric floating sustained-release tablets with…
The objective of this study was to develop a novel ofloxacin gastric floating system with different internal structures by paste extrusion printing and to explore the relationship between tablets with different structures and the release…
Investigating the Role of Excipients on the Physical Stability of Directly Compressed Tablets
Stability studies are an integral part of the drug development process for any drug product. In addition to monitoring chemical degradation, the physical stability of a drug product must also be evaluated to ensure that the drug release and…
Controlled and Local Delivery of Antibiotics by 3D Core/Shell Printed Hydrogel Scaffolds to Treat…
Soft tissue infections in open fractures or burns are major cause for high morbidity in trauma patients. Sustained, long-term and localized delivery of antimicrobial agents is needed for early eradication of these infections. Traditional…
Tocopherols as antioxidants in lipid-based systems: The combination of chemical and physicochemical…
Lipid oxidation is a major concern in the food, cosmetic, and pharmaceutical sectors. The degradation of unsaturated lipids affects the nutritional, physicochemical, and organoleptic properties of products and can lead to off-flavors and to…
Pharmatrans SANAQ® Sugar Spheres and MCC pellet excipients for controlled release
Recent trends have emphasised that multi-particulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different…
On-demand webinar: 3D printing of tablets – A new era of pharmaceutical manufacturing
Additive manufacturing is gaining increasing attention in the field of pharmaceutical manufacturing. Evaluations are mainly driven by advances in individualized therapy and fast track development of clinical trial material. Melt based…
Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system…
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of…
Microfluidic-Generated Immunomodulatory Nanoparticles and Formulation-Dependent Effects on…
Nanoparticles (NPs) have emerged as a highly useful and clinically translatable drug delivery platform for vast therapeutic payloads. Through the precise tuning of their physicochemical properties, NPs can be engineered to exhibit…
Spherical Agglomerates of Lactose Reduce Segregation in Powder Blends and Improve Uniformity of…
We report here on improved uniformity of blends of micronised active pharmaceutical ingredients (APIs) using addition of spherical agglomerates of lactose and enhanced blend flow to improve tablet content uniformity with higher API loads.…
Reversible Shielding and Immobilization of Liposomes and Viral Vectors by Tailored Antibody-Ligand…
Controlling the time and dose of nanoparticulate drug delivery by administration of small molecule drugs holds promise for efficient and safer therapies. This study describes a versatile approach of exploiting antibody-ligand interactions…
A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations
3D printing is a rapidly growing area of interest within pharmaceutical science thanks to its versatility in creating different dose form geometries and drug doses to enable the personalisation of medicines. Research in this area has been…
Production and Characterization of Cellulose Nanofiber Slurries and Sheets for Biomedical…
Cellulose nanomaterials are produced employing a multitude of methodologies including electrospinning, bacterial generation, acid digestion, and a variety of mechanical defibrillation techniques; the morphology of the nanomaterial produced…
Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres
The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and…
Clinical translation of advanced colonic drug delivery technologies
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a…
3D-Printed Coating of Extended-Release Matrix Tablets Effective Tool for Prevention of…
Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release.…
Zein as a versatile biopolymer: different shapes for different biomedical applications
In recent years, the interest regarding the use of proteins as renewable resources has deeply intensified. The strongest impact of these biomaterials is clear in the field of smart medicines and biomedical engineering. Zein, a vegetal…