Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
Studies on the pH-dependent solubility of various grades of calcium phosphate-based pharmaceutical…
Calcium phosphate-based pharmaceutical excipients, including calcium hydrogen phosphate anhydrous and dihydrate, calcium hydroxide phosphate have been well established in pharmaceutical technology for a very long time. Nowadays, they are of…
Hyaluronic Acid Nanogel as a Protein Delivery System
Purpose
Hyaluronic acid (HA) nanogel has hyaluronic acid in the main chain, a hydrophilic, biocompatible material with low toxicity, and a hydrophobic group in the side chain. A nanoordered gel is spontaneously formed, due to its…
Engineered-inhaled particles: influence of carbohydrates excipients nature on powder properties and…
Pulmonary drug administration has long been used for local or systemic treatment due to several advantages. Dry powder inhalers emerge as the most promising due to efficiency, ecologic, and drug stability concerns. Coarse lactose-carrier is…
High shear wet granulation: Improved understanding of the effects of process variables on granule…
High shear wet granulation (HSWG), as a widely used granulation technology, has been studied extensively. However, for the HSWG of formulations containing hydrophobic components, the influence of process variables on the properties of…
Optimized hydration dynamics in mucoadhesive xanthan-based trilayer vaginal films for the controlled…
Karaya gum, pectin and xanthan gum have been tested as candidates for manufacturing mucoadhesive trilayer films containing ethylcellulose and chitosan for the vaginal administration of the antiviral Tenofovir (TFV). The swelling profile…
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm
Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time. Current study attempts to…
Application of Reverse Engineering in the Field of Pharmaceutical Tablets Using Raman Mapping and…
Raman micro-spectroscopy technique offers a combination of relatively high spatial resolution with identification of components or mixtures of components in different sample areas, e.g. on the surface or the cross-section of a sample. This…
An update on microcrystalline cellulose in direct compression: Functionality, critical material…
Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in direct compression (DC) tablet formulations containing…
Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon:…
For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using…
PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell…
Role of polymers in the physical and chemical stability of amorphous solid dispersion: A case study…
Incorporating the amorphous drug in polymeric components has been demonstrated as a feasible approach to enhance the bioavailability of poorly water-soluble drugs. The objective of this study was to investigate the role of polymers in the…
The Expanded Role of Chitosan in Localized Antimicrobial Therapy
Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial…
European Paediatric Formulary: two draft texts released for public consultation
The European Directorate for the Quality of Medicines & HealthCare (EDQM) has just released Issue 4 of Pharmeuropa PaedForm, which contains two texts for public consultation, Simple syrup (preservative-free) and Phosphate 60 mg/mL Oral…
A Hybrid Model to Predict Formulation Dependent Granule Growth in a Bi-Component Wet Granulation…
In this study, a hybrid modeling framework was developed for predicting size distribution and content uniformity of granules in a bi-component wet granulation system with components of differing hydrophobicities. Two bi-component…
Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through…
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to…
Solving Compactability Issues for the Preparation of ODTs
Introduction
Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are poorly compressible or formed in a coated pellet. HiSORAD™, one of the…
On-demand webinar: From powder to DC oral solid dosage form – galenIQ™
galenIQ™ is a sweet-tasting water soluble filler binder derived from sugar beet. It is available in several different morphological forms which are suitable for the formulation and manufacture of oral solid dosage forms including tablets,…
Determination of Paclitaxel Solubility and Stability in the Presence of Injectable Excipients
Due to poor aqueous solubility of paclitaxel, cremophor is one of the excipients used to improve solubility in Taxol while it is responsible for a number of adverse effects such as anaphylactic shock. This research was aimed to determine…
A review on key aspects of wet granulation process for continuous pharmaceutical manufacturing of…
Wet granulation process is a major unit operation in production of pharmaceuticals as solid dosage oral formulation. Indeed, granulation is used to improve the formulation properties such as flowability, compressibility, and so on for…
Study and computational modeling of fatty acid effects on drug solubility in lipid-based systems
Lipid-based systems have many advantages in formulation of poorly water-soluble drugs but issues of a limited solvent capacity are often encountered in development. One of the possible solubilization approaches of especially basic drugs…
A customizable 3D printed device for enzymatic removal of drugs in water
The infiltration of drugs into water is a key global issue, with pharmaceuticals being detected in all nearly aqueous systems at often alarming concentrations. Pharmaceutical contamination of environmental water supplies has been shown to…
Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed…
Extrusion-based 3D-printing is an easy-to-use, cheap manufacturing technique that could be used to produce tailored precision medicines. The technique has an almost unlimited versatility since a multitude of print parameters can easily be…
Discover Omya’s state of the art pharmaceutical laboratory here!
Omya continues to build on its mineral expertise with extensive research & development. New facilities and equipment show their commitment to innovation. Their team of pharma experts is working on new tailor-made functional mineral…
Machine learning predicts the effect of food on orally administered medicines
Food-mediated changes to drug absorption, termed the food effect, are hard to predict and can have significant implications for the safety and efficacy of oral drug products in patients. Mimicking the prandial states of the human…
Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to…
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters…
Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines
In recent years, as the great success of arteannuin in the area of antimalarial treatment and commercial benefit, traditional Chinese medicine (TCM) has received great attention. However, most of the active pharmaceutical ingredients (API)…
Characterization of Tableting Speed-Dependent Deformation Properties of Active Pharmaceutical…
A quantitative evaluation method for determining the effect of tableting speed on the compression properties of pharmaceutical powders was investigated in this study. Cilostazol and ibuprofen were used as active pharmaceutical ingredients…
Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein…
Polysorbate excipients are commonly used as surfactants to stabilize therapeutic proteins in formulations. Degradation of polysorbates could lead to particle formation and instability of the drug formulation. We investigated how the fatty…
A linear scale-up approach to fluid bed granulation
Fluid bed granulation (FBG) is used extensively in the pharmaceutical industry and it is known to be a complex process, because the final product quality of the FBG process is determined by a complex interplay between the process…
Biphasic Drug Release from Rolled-Up Gelatin Capsules with a Cylindrical Cavity
Biphasic drug delivery systems are used for quick release of a specific amount of drug for immediate amelioration of a patient’s state, followed by sustained release, to avoid repeated administration. This type of delivery is often…
Lecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human…
In previous studies, lecithin-based nanoemulsions (NEs) have been shown to be skin friendly drug carrier systems. Due to their nontoxic properties, NEs might also be suitable as wound healing agents. Hence, different O/W NEs based on …
Pharma Drama Video: Probiotics for constipation and gut health in children and young people with…
In this video Simon Gaisford, Pharma Drama, explains a research project that he is running in partnership with Down's Syndrome UK, Down's Syndrome Research Foundation UK, 21 Together and a major probiotics manufacturer. The aim is to…
Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line…
The influence of different tableting process parameters on lead-lag was studied by collecting in-line near-infrared (NIR) spectra in the filling chamber of the tablet press feed frame and off-line NIR tablet data. Lead-lag is defined as the…
The impact of quantity of lipid based formulations with different compositions on the oral…
In this study, the effect of the quantity of lipid-based formulations (LBFs) on the oral absorption of ritonavir (RTV), a model for poorly water-soluble drugs, was investigated. Two types of LBFs, comprising short- and medium-chain lipids…