Parteck® MXP: two polymers, unparalleled value – Polyvinyl alcohol for hot melt extrusion
![Parteck® MXP: two polymers, unparalleled value](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Parteck®-MXP.jpg)
With two specifically engineered grades of polyvinyl alcohol, Merck´s Parteck® MXP polymers are optimal for generating high performing, solubility enhanced formulations via hot melt extrusion.
Enhancing drug solubility
Parteck® MXP polyvinyl alcohol for HME
Poor active pharmaceutical ingredient (API) solubility is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot melt extrusion (HME). With this technology, the API is dispersed within a polymer matrix to form an amorphous solid dispersion. Hot melt extrusion is a solvent-free process and so also provides unique benefits from a sustainability perspective.
Polyvinyl alcohol (PVA), from a chemical perspective, is ideal for application in HME due to its capabilities in stabilization of amorphous APIs, solubility enhancement, and precipitation inhibition. From a regulatory and safety perspective, PVA has a strong track record in oral solid dosage forms and is Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration.
Our Parteck® MXP range, Parteck® MXP 3-82 and Parteck® MXP 4-88, has been specifically designed with HME performance in mind.
Low melt viscosity, prolongation of supersaturation and the ability to stabilize active APIs over a broad temperature range are important assets of the Parteck® MXP range. Finally, both of our Parteck® MXP products come supported with extensive and market leading Emprove® dossiers of quality information.
![Parteck® MXP: two polymers, unparalleled value_Interested in learning more](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Parteck®-MXP_two-polymers-unparalleled-value_Enhancing-300x263.jpg)
![Parteck® MXP: two polymers, unparalleled value_HME](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Parteck®-MXP_two-polymers-unparalleled-value_HME-1024x514.jpg)
Parteck® MXP 3-82 polymer
Key parameters
![Presented values are considered for technical information only](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Presented-values-are-considered-for-technical-information-only-281x300.jpg)
With a lower degree of hydrolysis along the PVA chain, Parteck® MXP 3-82 polyvinyl alcohol is especially beneficial in forming strong interactions with hydrophobic drug molecules – in the solid state and in solution.
Due to this, Parteck® MXP 3-82 excipient has very high capabilities as a precipitation inhibitor and can maintain high levels of supersaturation for physiologically relevant timescales.
As a result, Parteck® MXP 3-82 polyvinyl alcohol can provide solubility enhancement for even the most challenging molecules. Furthermore, Parteck® MXP 3-82 is compliant with Ph. Eur.
![Polyvinyl alcohol structure](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Polyvinyl-alcohol-structure-282x300.jpg)
Parteck® MXP 3-82 dissolution with a
strong precipitation inhibition profile
![Parteck® MXP 3-82 dissolution with astrong precipitation inhibition profile](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Parteck®-MXP-3-82-dissolution-with-a-300x194.jpg)
strong precipitation inhibition profile
![There’s no such thing as a one-size-fits all formulation](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/there´s-no-1024x279.jpg)
Parteck® MXP 4-88 polymer
Key parameters
![Presented values are considered for technical information only.](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Presented-values-are-considered-for-technical-information-only.-281x300.jpg)
With a hydrolysis grade of 88%, Parteck® MXP 4-88 polyvinyl alcohol is more hydrophilic, which provides unique benefits for stabilization of certain molecules in the amorphous form.
Furthermore, with a uniquely high thermal application range, Parteck® MXP 4-88 excipient can be utilized for molecules across a broad range of melting temperatures while still providing strong performance, including those classically seen as unsuitable for extrusion due to high melting points.
Application range
![Application range](https://www.pharmaexcipients.com/wp-content/uploads/2023/05/Application-range-1024x684.jpg)
See the full brochure on “Parteck® MXP: two polymers, unparalleled value” here
(click the picture to download the brochure)
Source: Merck brochure “Parteck® MXP: two polymers, unparalleled value”
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