Oral Solid Dose – Direct Comparison of Pharmacel® 101 and Pharmacel® 102

High-quality excipients

Oral Solid Dose

A comprehensive range of highly consistent excipients for OSD formulations, including a full range of lactose (milled monohydrate, sieved monohydrate, micronized, anhydrous, spray dried, and granulated), cellulosics and starches portfolio comprising of microcrystalline cellulose (MCC), croscarmellose sodium, sodium starch glycolate, starches and multifunctional, co-processed excipients.

DFE’s product portfolio in this range includes, among others, the two popular products Pharmacel® 101 and Pharmacel® 102. Find out more about these two products in a direct comparison here:

Pharmacel® 101

Pharmacel® 101 Microcrystalline cellulose (MCC) has been developed specifically as a key component for wet granulation and dry granulation formulations. DFE Pharma offers Pharmacel® 101 from two high quality production sites.

Pharmacel® 102

Microcrystalline cellulose (MCC) compacts more effectively than any other excipient making Pharmacel® 102 the ideal choice for direct compression and dry granulation formulations. It’s versatility in direct compression extends to very high dose actives, where compactability is at a premium.

Benefits

Consistency

Pharmacel® is industry leading with high batch-to-batch consistency on functional properties allowing you low risk during production and in your formulation development.

Pharmacel® 101

Pharmacel® 102

Pharmacel® and lactose formulations

DFE Pharma is the only global excipient manufacturer offering it’s customers both lactose and microcrystalline cellulose products for development of pharmaceutical formulations. Combination of Pharmacel® with one of the lactose grades offered by DFE Pharma provides additional benefit to formulations, by achieving the perfect combination of brittle and plastic excipient behavior.

Pharmacel® 101

Wet granulation

Pharmacel® 101 microcrystalline cellulose (MCC) has
been developed specifically as a key component for
wet granulation formulations. Using Pharmacel® 101
ensures even distribution of the granulating fluid,
which in turn means uniform granulation and drying
processes. Wet granulation with Pharmacel® 101 is a
reliable, easily repeatable and robust process. Tablets
made using Pharmacel® 101 show excellent
compaction and disintegration properties.

Dry granulation

Pharmacel® 101 microcrystalline cellulose (MCC)
is also an ideal excipient for use in dry granulated
formulations. Ribbons do not stick to the compaction
rolls during roller compaction and dry granulation
can be used in formulations with a high drug dosage.
For dry granulation Pharmacel® 101 opens up vital
production synergies. Used with a brittle excipient,
such as SuperTab® 21AN anhydrous lactose, the
result is an ideal combination of high tablet strength
and insensitivity to re-compaction, leading to
outstandingly robust dry granulation formulations.

Pharmacel® 102

Physical – chemical properties

Pharmacel® 102 has good flow properties enabling
high speed direct compression tableting. In addition,
tablets of high tensile strength with low ejection
forces can be obtained with low compaction forces.
Pharmacel® 102 has some lubrication properties
facilitating smooth tableting experience.