Applications of Polymers in Colon Drug Delivery
Colon-targeted drug delivery possesses numerous advantages in pharmaceutical delivery systems. Both local and systemic deliveries of active ingredients are possible with help of polymers in colon-targeted delivery.
Targeting colon can be helpful in prevention of drugs from the stomach acid and other digestive enzymes of small intestine. Various natural and synthetic sourced polymers can be used to ensure the targeted and control drug delivery at colon. Different marketed technologies such as Eudracol, CODES, microbial-triggered colon-targeted osmotic pump, MMX (Multimatrix technology), Peltab (pelletized tablet), PHLORAL, and Colal-Pred systems are giving promising results in the targeted drug moiety to site of colon.
These drug delivery systems have been designed in that way that it can deliver the drug quantitatively to the colon and then trigger the release of drug. This chapter will cover different types of natural as well synthetic polymers that can be used for the formulation of colon-specific drug targeting systems.
Article Information: Denish Bardoliwala, Dipesh Baradia, Jitendra Amrutiya, Ambikanandan Misra. Applications of Polymers in Drug Delivery (Second Edition). https://doi.org/10.1016/B978-0-12-819659-5.00007-0