Formulation And Characterization Of Provesicular Based Drug Delivery System For Effective Transdermal Delivery Of Antifungal Drug
Oral intake of Itraconazole (ITZ) causes severe side effects in the gastrointestinal tract and has low bioavailability ~55%. Owing to these disadvantages, Transdermal drug delivery system (TDDS) of such antifungal agents can overcome such issues and can improve the efficacy and bioavailability. The aim of this study was to evaluate the potential of proniosomes as a transdermal drug delivery system for ITZ by encapsulating the drug in various formulations of proniosomal gel by Coacervation-phase separation method. Among all the formulated proniosomal gel formulation TF5 containing tween 20 was found to be the most appropriate surfactant and was selected for preparing Transdermal proniosomal hydrogel which was formulated using different concentrations of Carbopol and HPMC. These gels were characterized for pH, spreadability, drug content and in-vitro diffusion study and stability studies wherein the optimized formulation (G2) showed the values of 7.01, 33.70 g.cm/sec, 99.5% and 87.83% (p<0.05). The drug release kinetics studies revealed that release was prolonged up to 8hrs and release pattern was found to be diffusion controlled which was confirmed by Higuchi’s plot. The results of this study suggest that proniosomes are promising nano vesicular carriers to enhance the transdermal delivery of ITZ.
Materials
Itraconazole was obtained as a gift sample from Srijan Medi Solution Private Limited (India). Lipoid P 75 3 was obtained as gift sample from Lipoid GmBh (India), HPMC K4M was obtained as a gift sample from Colorcon (Goa, India), Cholesterol, Span 20, 40, 60, 80, Tween 20, 40, 80, Triethanolamine was obtained from Molychem (India), Propylene Glycol, Methyl Paraben, Propyl Paraben was obtained from Lobachemei (India), Ethanol was obtained from Changshu Hongsheng Fine Chemical (India), Carbopol 974P was obtained from Lubrizol (India).
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Akshata Rajesh Shirodker, Formulation And Characterization Of Provesicular Based Drug Delivery System For Effective Transdermal Delivery Of Antifungal, Drug, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 331-346
DOI: 10.5281/zenodo.8348393